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The expression of the genes coding for proopiomelanocortin (POMC (zeige POMC Proteine)), proenkephalin (PENK) and prodynorphin (PDYN (zeige PDYN Proteine)) in porcine luteal cells isolated from corpora lutea (CL) collected on days 3-6, 8-10 and 13-16 of the oestrous cycle is reported.
Loss of phosphorylation enhances NANOG activity in reprogramming. Mutation S65A alone has the most significant impact on increasing NANOG reprogramming capacity.
Nanog (zeige NANOG Proteine), Oct4 (zeige POU5F1 Proteine) and Tet1 (zeige TET1 Proteine) interplay in establishing stem cell pluripotency has been described.
Members of the SIN3A/HDAC2 corepressor complex are enriched in an extended NANOG interactome.
Functional studies revealed that knockdown of Nanog eliminated the mESC self-renewal-promoting ability of Sp5. Finally, we demonstrated that the self-renewal-promoting function of Sp5 was largely dependent on its zinc finger domains
Otx2 (zeige OTX2 Proteine)-mediated Nanog (zeige NANOG Proteine) regulation contributes to the integrity of the embryonic stem cell state and cell lineage specification in preimplantation development (zeige MTA2 Proteine).
Maintenance of pluripotency is regulated by a network of transcription factors coordinated by Oct4 (zeige POU5F1 Proteine), Sox2 (zeige SOX2 Proteine), and Nanog (zeige NANOG Proteine); Trim24 (zeige TRIM24 Proteine) significantly improved efficiency of cellular reprogramming, demonstrating its direct functionality in establishing pluripotency.
studies highlight a new hypoxia-induced pathway in which NANOG (zeige NANOG Proteine) activates BNIP3L (zeige BNIP3L Proteine) expression, contributing to autophagy induction in hypoxic tumor cells and their resistance to killing by CTL
Genetic reporters can compromise the behavior of important pluripotency-sustaining positive feedback loops, and induce a bifurcation in the underlying dynamics that gives rise to heterogeneous Nanog expression patterns in reporter cell lines that are not representative of the wild-type; findings help explain the range of published observations of Nanog variability and highlight the problem of measurement in live cells.
Here the authors couple mutagenesis with functional and dimerization assays to show that the number of tryptophans within the tryptophan repeat is linked to the strength of homodimerization, Sox2 (zeige SOX2 Proteine) heterodimerization and self-renewal activity.
In mouse model of acute uterine injury, Nanog (zeige NANOG Proteine) homebox (NANOG (zeige NANOG Proteine)) expression reached a peak at 6 h, while sex-determining region Y (zeige SRY Proteine)-box2 (SOX2 (zeige SOX2 Proteine)) and octamer-binding protein 4 (OCT4 (zeige POU5F1 Proteine)) peaked later at 12 h after lipopolysaccharide (LPS (zeige TLR4 Proteine)) treatment.
The concentration of PENK 143-183 was significantly greater in patients with Moyamoya disease (MMD) than control patients and decreased in an age-dependent manner in MMD.
Nav1.7 (zeige SCN9A Proteine) deletion has profound effects on gene expression, leading to an upregulation of enkephalin precursor Penk mRNA and met-enkephalin protein in sensory neurons.
The PENK polymorphism-and potentially opioid neurotransmission more generally-modulates functioning and structural integrity of brain regions.
Serum PENK-A levels were not associated with all-cause mortality in patients with type 2 diabetes mellitus, and its association with cardiovascular mortality was strongly attenuated after accounting for all traditional risk factors.
BSP (zeige KLK6 Proteine) demonstrated that emodin, to a certain degree, affected the demethylation of tumor-suppressor genes P16, RASSF1A (zeige RASSF1 Proteine), and ppENK in the pancreatic cancer cell line PANC-1.
increased plasma PENK-A levels are associated with disease severity and in-hospital mortality after acute intracerebral hemorrhage.
enhanced plasma proenkephalin A could be a useful, complementary tool to predict short- or long-term clinical outcome after severe traumatic brain injury.
EPS led to the discovery of two novel immunomodulatory proteins, MFAP5 (zeige MFAP5 Proteine) and PENK that when administered to mice subjected to endotoxemic shock, reversed the cytokine storm and provided a significant survival benefit
Data from women undergoing hysterectomy for uterine fibroids suggest that uterine isthmian-cervical region exhibits nerve fibers expressing enkephalin (ENK); uterine fundus/corpus myoma pseudocapsules do not exhibit nerve fibers expressing ENK.
Promoter methylation of WIF1 (zeige WIF1 Proteine), PENK and NPY (zeige NPY Proteine) is associated with colorectal adenocarcinoma (CRC (zeige CALR Proteine)) diagnosis and can be used to CRC (zeige CALR Proteine) from other cancers.
Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT-3'. When overexpressed, promotes cells to enter into S phase and proliferation (By similarity).
, ES cell-associated protein 4
, early embryo specific expression NK family
, early embryo specific expression NK-type homeobox protein
, homeobox protein NANOG
, homeobox transcription factor Nanog
, enkephalin A
, preproenkephalin 1
, spermatogenic-specific proenkephalin
, Proenkephalin A
, preproenkephalin 2
, proenkephalin 1
, proenkephalin 2
, proenkephalin related sequence
, enkephalin a