Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Weitere Synonyme anzeigen
Wählen Sie die gewünschte Spezies
The expression of the genes coding for proopiomelanocortin (POMC), proenkephalin (PENK) and prodynorphin (PDYN) in porcine luteal cells isolated from corpora lutea (CL) collected on days 3-6, 8-10 and 13-16 of the oestrous cycle is reported.
High PENK is associated with increased risk of CKD defined by eGFR in men, but not in women. No association of PENK with CKD defined by urinary albumin excretion UAE was observed.
These results demonstrate that proinflammatory molecules and endogenous enkephalin have opposite gene regulation during Dry eye disease.
These data indicate that in untrained women exercise training will not change resting of plasma Peptide F concentrations unless both forms of exercise are performed but will result in significant increases in the immediate post-exercise responses.
The concentration of PENK 143-183 was significantly greater in patients with Moyamoya disease (MMD) than control patients and decreased in an age-dependent manner in MMD.
Peptide F is bound to white blood cells in the blood. Exercise alters Peptide F in the plasma and white blood cell blood fractions.
Nav1.7 deletion has profound effects on gene expression, leading to an upregulation of enkephalin precursor Penk mRNA and met-enkephalin protein in sensory neurons.
The PENK polymorphism-and potentially opioid neurotransmission more generally-modulates functioning and structural integrity of brain regions.
Serum PENK-A levels were not associated with all-cause mortality in patients with type 2 diabetes mellitus, and its association with cardiovascular mortality was strongly attenuated after accounting for all traditional risk factors.
BSP demonstrated that emodin, to a certain degree, affected the demethylation of tumor-suppressor genes P16, RASSF1A, and ppENK in the pancreatic cancer cell line PANC-1.
increased plasma PENK-A levels are associated with disease severity and in-hospital mortality after acute intracerebral hemorrhage.
enhanced plasma proenkephalin A could be a useful, complementary tool to predict short- or long-term clinical outcome after severe traumatic brain injury.
EPS led to the discovery of two novel immunomodulatory proteins, MFAP5 and PENK that when administered to mice subjected to endotoxemic shock, reversed the cytokine storm and provided a significant survival benefit
Data from women undergoing hysterectomy for uterine fibroids suggest that uterine isthmian-cervical region exhibits nerve fibers expressing enkephalin (ENK); uterine fundus/corpus myoma pseudocapsules do not exhibit nerve fibers expressing ENK.
Promoter methylation of WIF1, PENK and NPY is associated with colorectal adenocarcinoma (CRC) diagnosis and can be used to CRC from other cancers.
Expression of preproenkephalin is significantly decreased in brain from HIV-1 infected patients compared to HIV-1 negative subjects.
The findings suggest an important role for Neuroticism as an endophenotype linking PENK polymorphisms to cannabis-dependence vulnerability synergistically amplifying the apparent genetic risk.
found higher levels for MOR mRNA (+27%) in schizophrenia but no differences in DOR or proenkephalin mRNAs
Findings indicate the unique function of cathepsin V for producing enkephalin and neuropeptide Y (NPY) neuropeptides required for neurotransmission in health and neurological diseases.
Differential tertiary conformations of PE subdomains undergo ordered proteolytic processing to generate active enkephalin peptides for cell-cell communication in the nervous and endocrine systems.
we demonstrated reduced ppE expression in patients with elevated psychological distress.
PENK knockout exhibited fewer bouts of licking than wild types, even though the length of bouts was similar to that of wild types, a pattern that suggests diminished food motivation.
PENK KO mice do not display anxiety and depression-related behavioral changes after chronic mild stress.
upregulation of striatal enkephalin might have a role in early stage Huntington Disease in a mouse model
Preproenkephalin-enhanced green fluorescent protein (GFP) transgenic mice were used to study ENKergic neuron distribution patterns.
ENKephalinergic neurons develop according to a rostrocaudal and ventrodorsal gradient.
Met-enkephalin levels in neuronal projections from entorhinal cortex and dentate gyrus were increased, as were preproenkephalin mRNA levels. Elevations may contribute to cognitive impairments. (Met-enkephalin, preproenkephalin)
c-fos expression in specific brain areas in preproenkephalin deficiency
Preproenkephalin deletion in Hyp mice (Phex-deficient) partially rescues their bone mineralization defect.A role for Penk in osteoblast differentiation.
Inter-strain differences in PENK and PDYN genes expression in the nucleus accumbens parallel sensitivity of the selected mouse strains to rewarding effects of morphine.
Morphine dependence is examined in preproenkephalin knockout mice.
A defect in activation seen in preproenkephalin (Penk)-deficient T cells results in a reduced number of cells entering into cell cycle; proliferation can be rescued by increasing antigen or by co-incubation of Penk-deficient cells with wild-type cells.
mice with the Penk1 mutation in the DBA/2J, but not on other genetic backgrounds, showed an increased opioid-dependent stress-induced analgesia
Endogenous opioid peptides derived from preproenkephalin are involved in the antinociceptive and rewarding properties of nicotine and participate in the expression of physical nicotine dependence.
These data implicate enkephalin as a signaling molecule in the control of hypoxic depression of metabolism in mice.
Preproenkephalin knockout mice show no depression-related phenotype.
Increase in ACTH level after zero-maze test failed to reach the level of significance in Penk1(-/-) mice.
Preproenkephalin and GABA colocalized in a subpopulation of neurons in the spinal dorsal horn. They are likely to represent local inhibitory dorsal horn interneurons involved in the modulation of pain transmission.
As PPE-derived peptides are endogenous ligands for MOR in the neostriatum and few axon collaterals of matrix neurons enter the striosome compartment, the present results raised the question of the target of those peptides produced by matrix neurons.
Administration of the antagonist prevented the acquisition of MDMA-induced CPP, suggesting an implication of the delta opioid receptors in this behavior.
new heptapeptide with putative differential activity than the other peptides derived from the mammalian proenkephalins
Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT-3'. When overexpressed, promotes cells to enter into S phase and proliferation (By similarity).
, enkephalin A
, preproenkephalin 1
, spermatogenic-specific proenkephalin
, Proenkephalin A
, preproenkephalin 2
, proenkephalin 1
, proenkephalin 2
, proenkephalin related sequence
, enkephalin a