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The expression of the genes coding for proopiomelanocortin (POMC (zeige POMC Proteine)), proenkephalin (PENK) and prodynorphin (PDYN (zeige PDYN Proteine)) in porcine luteal cells isolated from corpora lutea (CL) collected on days 3-6, 8-10 and 13-16 of the oestrous cycle is reported.
High PENK is associated with increased risk of CKD defined by eGFR (zeige EGFR Proteine) in men, but not in women. No association of PENK with CKD defined by urinary albumin (zeige ALB Proteine) excretion UAE was observed.
The concentration of PENK 143-183 was significantly greater in patients with Moyamoya disease (MMD) than control patients and decreased in an age-dependent manner in MMD.
Nav1.7 (zeige SCN9A Proteine) deletion has profound effects on gene expression, leading to an upregulation of enkephalin precursor Penk mRNA and met-enkephalin protein in sensory neurons.
The PENK polymorphism-and potentially opioid neurotransmission more generally-modulates functioning and structural integrity of brain regions.
Serum PENK-A levels were not associated with all-cause mortality in patients with type 2 diabetes mellitus, and its association with cardiovascular mortality was strongly attenuated after accounting for all traditional risk factors.
BSP (zeige KLK6 Proteine) demonstrated that emodin, to a certain degree, affected the demethylation of tumor-suppressor genes P16, RASSF1A (zeige RASSF1 Proteine), and ppENK in the pancreatic cancer cell line PANC-1.
increased plasma PENK-A levels are associated with disease severity and in-hospital mortality after acute intracerebral hemorrhage.
enhanced plasma proenkephalin A could be a useful, complementary tool to predict short- or long-term clinical outcome after severe traumatic brain injury.
EPS led to the discovery of two novel immunomodulatory proteins, MFAP5 (zeige MFAP5 Proteine) and PENK that when administered to mice subjected to endotoxemic shock, reversed the cytokine storm and provided a significant survival benefit
Data from women undergoing hysterectomy for uterine fibroids suggest that uterine isthmian-cervical region exhibits nerve fibers expressing enkephalin (ENK); uterine fundus/corpus myoma pseudocapsules do not exhibit nerve fibers expressing ENK.
PENK knockout exhibited fewer bouts of licking than wild types, even though the length of bouts was similar to that of wild types, a pattern that suggests diminished food motivation.
PENK KO mice do not display anxiety and depression-related behavioral changes after chronic mild stress.
upregulation of striatal enkephalin might have a role in early stage Huntington Disease (zeige HTT Proteine) in a mouse model
Preproenkephalin-enhanced green fluorescent protein (GFP) transgenic mice were used to study ENKergic neuron distribution patterns.
Met-enkephalin levels in neuronal projections from entorhinal cortex and dentate gyrus were increased, as were preproenkephalin mRNA levels. Elevations may contribute to cognitive impairments. (Met-enkephalin, preproenkephalin)
c-fos expression in specific brain areas in preproenkephalin deficiency
Preproenkephalin deletion in Hyp (zeige PHEX Proteine) mice (Phex (zeige PHEX Proteine)-deficient) partially rescues their bone mineralization defect.A role for Penk in osteoblast differentiation.
Inter-strain differences in PENK and PDYN (zeige PDYN Proteine) genes expression in the nucleus accumbens parallel sensitivity of the selected mouse strains to rewarding effects of morphine.
Morphine dependence is examined in preproenkephalin knockout mice.
Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT-3'. When overexpressed, promotes cells to enter into S phase and proliferation (By similarity).
, enkephalin A
, preproenkephalin 1
, spermatogenic-specific proenkephalin
, Proenkephalin A
, preproenkephalin 2
, proenkephalin 1
, proenkephalin 2
, proenkephalin related sequence
, enkephalin a