This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008].
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Neueste Publikationen zu unseren Speckle-Type POZ Protein Produkten
Lutz, Pace, Arnold: "Rotavirus NSP1 Associates with Components of the Cullin RING Ligase Family of E3 Ubiquitin Ligases." in: Journal of virology, Vol. 90, Issue 13, pp. 6036-48, (2016) (PubMed).
Synonyme und alternative Namen zu Speckle-Type POZ Protein
speckle type BTB/POZ protein (SPOP), speckle-type POZ protein (Spop), speckle-type POZ protein (spop), speckle type BTB/POZ protein (Spop), speckle type POZ protein S homeolog (spop.S), AI315626, BTBD32, Pcif1, spop, TEF2, tef2, zgc:64140
Bezeichner auf Proteinebene für Speckle-Type POZ Protein