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Membrane localization and dynamics of geranylgeranylated Rab5 hypervariable region has been reported.
study elucidated a novel Malat1-miR-101-STMN1/RAB5A/ATG4D regulatory network that Malat1 activates autophagy and promotes cell proliferation by sponging miR-101 and upregulating STMN1, RAB5A and ATG4D expression in glioma cells
In conclusion, mutant KRAS promotes endosomal degradation in PDAC cell lines, which is impaired by KRAS silencing. Moreover, KRAS silencing activates RAB5A upregulation and drives PDAC subtype-dependent modulation of endosome trafficking.
siRNA knockdown of Rab5a or overexpression of miR (zeige MLXIP Proteine)-494 in human macrophages significantly inhibits the survival of the parasites
our results show that Rab5a is overexpressed in pancreatic cancer and promotes aggressive biological behavior through regulation of the Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling pathway.
CMTM3 (zeige CMTM3 Proteine) decreases EGFR (zeige EGFR Proteine) expression, facilitates EGFR (zeige EGFR Proteine) degradation, and inhibits the EGF (zeige EGF Proteine)-mediated tumorigenicity of gastric cancer cells by enhancing Rab5 activity.
High RAS-associated protein (zeige RGL2 Proteine) RAB5 expression correlated with the presence of lymphatic invasion and venous invasion and low E-cadherin (zeige CDH1 Proteine) expression.
downregulated Rab5a led to slowed cell growth, decreased numbers of migrated cells, decreased numbers of cells at the G0G1 phase and a higher apoptosis rate. However, PDGF (zeige PDGFA Proteine) significantly rescued these phenomena caused by siRNA against Rab5a
results suggest a new mechanism in which Rab5 induces a change in flexibility of EEA1 (zeige EEA1 Proteine), generating an entropic collapse force that pulls the captured vesicle towards the target membrane to initiate docking and membrane fusion
structural differences may provide an opportunity to selectively target one Rab5 state and lead to new approaches in the development of Rab5-specific therapies
SH3GLB1 (zeige SH3GLB1 Proteine) controls nicotinic acetylcholine receptors endocytic trafficking in a phosphorylation- and RAB5-dependent manner at steps upstream of autophagosome formation.
E. chaffeensis secretes Etf-1 (zeige ETF1 Proteine) to induce autophagy to repurpose the host cytoplasm and capture nutrients for its growth through RAB5 and class III PtdIns3K, while avoiding autolysosomal killing.
These data highlight a requirement of Rab5 and the endosomal system for the regulation of gluconeogenic gene expression that has important implications for metabolic diseases.
Inpp5e (zeige INPP5E Proteine), through functional interactions with Rab20 (zeige RAB20 Proteine) on the phagosome, activates Rab5, which, in turn, increases PtdIns3P and delays phagosome acidification.
FGF21 (zeige FGF21 Proteine) has a role in promoting endothelial cell angiogenesis through a dynamin-2 (zeige DNM2 Proteine) and Rab5 dependent pathway
In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin (zeige NCDN Proteine) palmitoylation in its targeting to Rab5-positive endosomes.
In mammalian cells, p110beta acts as a molecular sensor for growth factor availability and induces autophagy by activating a Rab5-mediated signaling cascade.
Data show that Rinl is closely associated with the cytoskeleton and thus contributes to the spatial control of Rab5a and Rab22 signaling at actin-positive compartments.
Data reveal the affinity of Rabex-5 (zeige RABGEF1 Proteine)/Rabaptin-5/Rab5-GTP (zeige AK3 Proteine) interaction in the cell, which is quantitatively related to the Rabex-5 (zeige RABGEF1 Proteine) concentration for the onset of the indirect
Rab5 regulates and coordinates different endocytic mechanisms through its effector Rabankyrin-5 (zeige ANKFY1 Proteine)
Expression of dominant negative Rab5 and Rab7 (zeige RAB7A Proteine) mutants, but not the dominant negative Rab11 (zeige RAB11A Proteine) mutant, significantly inhibited classical swine fever virus replication. These results were confirmed by silencing of Rab5 and Rab7 (zeige RAB7A Proteine).
Dominant-negative mutant rab5 inhibits FMDV infection of IBRS-2 cells.
Required for the fusion of plasma membranes and early endosomes (By similarity).
, Rab5a, GTPase
, hypothetical protein
, Ras-related protein Rab-5A
, ras-related protein rab-5a
, RAB5A, member RAS oncogene family
, ras-related protein Rab-5A
, RAS-associated protein RAB5A
, small GTP-binding protein rab5
, GTP-binding protein (rab5)