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The expression level of EMC-6 is significantly elevated in cervical cancer, without significant correlation with Beclin1 (zeige BECN1 Proteine) and Rab5a.
Here the authors show that Rab5 is monoubiquitinated on K116, K140, and K165. Structural analysis combined with biochemical data revealed that interactions with downstream effectors were impeded in Rab5 monoubiquitinated at K140, whereas GDP release and GTP (zeige AK3 Proteine) loading activities were altered in Rab5 monoubiquitinated at K165.
Rab5a is overexpressed in oral cancer tissue samples and promotes the malignant phenotype through EMT (zeige ITK Proteine) and the ERK (zeige EPHB2 Proteine)/MMP2 (zeige MMP2 Proteine) signaling pathway.
Rab5 was found abundantly localized in macrophage rich areas of human atherosclerotic lesions.Rab5 plays an important role in modulating the intracellular cholesterol of macrophages and consequently mediating the formation of foam cells.
The results were indicative that rabies virus N proficiently colocalized with Rab5/EEA1 (zeige EEA1 Proteine) and Rab7 (zeige RAB7B Proteine)/LAMP1 (zeige LAMP1 Proteine) in both cell lines at 24 and 48 h post-infection, while N titers significantly decreased in early infection of rabies virus.
Membrane localization and dynamics of geranylgeranylated Rab5 hypervariable region has been reported.
study elucidated a novel Malat1-miR-101-STMN1/RAB5A/ATG4D regulatory network that Malat1 activates autophagy and promotes cell proliferation by sponging miR-101 and upregulating STMN1, RAB5A and ATG4D expression in glioma cells
In conclusion, mutant KRAS promotes endosomal degradation in PDAC cell lines, which is impaired by KRAS silencing. Moreover, KRAS silencing activates RAB5A upregulation and drives PDAC subtype-dependent modulation of endosome trafficking.
siRNA knockdown of Rab5a or overexpression of miR (zeige MLXIP Proteine)-494 in human macrophages significantly inhibits the survival of the parasites
our results show that Rab5a is overexpressed in pancreatic cancer and promotes aggressive biological behavior through regulation of the Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling pathway.
SH3GLB1 (zeige SH3GLB1 Proteine) controls nicotinic acetylcholine receptors endocytic trafficking in a phosphorylation- and RAB5-dependent manner at steps upstream of autophagosome formation.
E. chaffeensis secretes Etf-1 (zeige ETF1 Proteine) to induce autophagy to repurpose the host cytoplasm and capture nutrients for its growth through RAB5 and class III PtdIns3K, while avoiding autolysosomal killing.
These data highlight a requirement of Rab5 and the endosomal system for the regulation of gluconeogenic gene expression that has important implications for metabolic diseases.
Inpp5e (zeige INPP5E Proteine), through functional interactions with Rab20 (zeige RAB20 Proteine) on the phagosome, activates Rab5, which, in turn, increases PtdIns3P and delays phagosome acidification.
FGF21 (zeige FGF21 Proteine) has a role in promoting endothelial cell angiogenesis through a dynamin-2 (zeige DNM2 Proteine) and Rab5 dependent pathway
In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin (zeige NCDN Proteine) palmitoylation in its targeting to Rab5-positive endosomes.
In mammalian cells, p110beta acts as a molecular sensor for growth factor availability and induces autophagy by activating a Rab5-mediated signaling cascade.
Data show that Rinl is closely associated with the cytoskeleton and thus contributes to the spatial control of Rab5a and Rab22 signaling at actin-positive compartments.
Data reveal the affinity of Rabex-5 (zeige RABGEF1 Proteine)/Rabaptin-5/Rab5-GTP (zeige AK3 Proteine) interaction in the cell, which is quantitatively related to the Rabex-5 (zeige RABGEF1 Proteine) concentration for the onset of the indirect
Rab5 regulates and coordinates different endocytic mechanisms through its effector Rabankyrin-5 (zeige ANKFY1 Proteine)
Expression of dominant negative Rab5 and Rab7 (zeige RAB7A Proteine) mutants, but not the dominant negative Rab11 (zeige RAB11A Proteine) mutant, significantly inhibited classical swine fever virus replication. These results were confirmed by silencing of Rab5 and Rab7 (zeige RAB7A Proteine).
Dominant-negative mutant rab5 inhibits FMDV infection of IBRS-2 cells.
Required for the fusion of plasma membranes and early endosomes (By similarity).
, Rab5a, GTPase
, hypothetical protein
, Ras-related protein Rab-5A
, ras-related protein rab-5a
, RAB5A, member RAS oncogene family
, ras-related protein Rab-5A
, RAS-associated protein RAB5A
, small GTP-binding protein rab5
, GTP-binding protein (rab5)