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edited form of miR (zeige MLXIP Proteine)-378a-3p preferentially binds to the 3'-UTR of the PARVA oncogene (zeige RAB1A Proteine) and inhibits its expression, thus preventing the progression of melanoma towards the malignant phenotype
Protein expression of alpha-Parvin increases with colorectal cancer progression.
PARVA promotes metastasis by modulating ILK (zeige ILK Proteine) signalling pathway in lung adenocarcinoma
alpha-Parvin, a pseudopodial constituent, was found to promote migration of breast cancer cells and to be expressed exclusively by Invasive lobular carcinoma
Actopaxin plays a role in hepatocellular carcinoma progression and metastasis, by way of regulation of cell invasiveness and motility, an epithelial-mesenchymal transition process, and chemosensitivity to cytotoxic drugs.
beta2-adaptin (zeige AP2B1 Proteine) is shown to bind to the focal adhesion protein actopaxin and localize to focal adhesions during cells spreading in an actopaxin dependent manner
alpha-parvin, beta-parvin (zeige PARVB Proteine) and migfilin (zeige FBLIM1 Proteine) were expressed in tumor cells in 53%, 2%, 28% and 53% of effusions and 57%, 20%, 83% and 25% of solid lesions, respectively.
Actopaxin phosphorylation is required for matrix degradation and cell invasion via regulation of Rho GTPase (zeige RACGAP1 Proteine) signaling.
results also identify the integrin-linked kinase (ILK (zeige ILK Proteine)) and alpha-parvin proteins as a new molecular partner and target, respectively, of the Lnk (zeige SH2B3 Proteine) adaptor.
the alpha-parvin CH2 (zeige Acyp1 Proteine)-paxillin (zeige PXN Proteine) LD1 complex has a role in focal adhesion assembly
this study has identified a new role for Parvin and alphaPix (zeige ARHGEF6 Proteine) downstream of the integrin-ILK (zeige ILK Proteine) signaling axis for mammary epithelial cell differentiation.
These results provide important evidence for a crucial role of the PINCH-1 (zeige LIMS1 Proteine)-ILK (zeige ILK Proteine)-alpha-parvin complex in the control of podocyte adhesion, morphology, and survival.
Results describe the roles of the ILK (zeige ILK Proteine)-PINCH (zeige LIMS1 Proteine)-parvin triad proteins in the maturation of focal adhesions.
Findings show that alpha-pv represents an essential adhesion checkpoint that controls RhoA (zeige RHOA Proteine)/ROCK-mediated contractility in vSMCs.
This gene encodes a member of the parvin family of actin-binding proteins. Parvins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. The encoded protein is part of the integrin-linked kinase signaling complex and plays a role in cell adhesion, motility and survival.
, calponin-like integrin-linked kinase-binding protein
, matrix-remodeling-associated protein 2
, parvin, alpha