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anti-Human LRP1 Antikörper:
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Human Polyclonal LRP1 Primary Antibody für IHC, WB - ABIN2787740
Hentschke, Poli-de-Figueiredo, da Costa, Kurlak, Williams, Mistry: Is the atherosclerotic phenotype of preeclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors? Role of a small-for-gestational-age phenotype. in Journal of lipid research 2013
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Human Monoclonal LRP1 Primary Antibody für FACS - ABIN2472830
Moestrup, Gliemann, Pallesen: Distribution of the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues. in Cell and tissue research 1992
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Human Monoclonal LRP1 Primary Antibody für ELISA, FACS - ABIN2472827
Moestrup, Hokland: Surface expression of the alpha 2-macroglobulin receptor on human malignant blood cells. in Leukemia research 1992
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Results indicate that holo-Lf, but not apo (zeige C9orf3 Antikörper)-Lf, increases TE expression through LRP-1 in human dermal fibroblasts and suggest that holo-Lf and TGF-beta1 (zeige TGFB1 Antikörper) enhance TE expression by activating the PI3K (zeige PIK3CA Antikörper)/Akt1 (zeige AKT1 Antikörper) and PI3K (zeige PIK3CA Antikörper)/Akt2 (zeige AKT2 Antikörper) pathways, respectively.
Development of a monoclonal anti-ADAMTS-5 (zeige ADAMTS5 Antikörper) antibody that specifically blocks the interaction with LRP1.
MMP-13 (zeige MMP13 Antikörper) may play a role on physiological turnover of cartilage extracellular matrix and that LRP1 is a key modulator of extracellular levels of MMP-13 (zeige MMP13 Antikörper) and its internalization is independent of the levels of ADAMTS-4 (zeige ADAMTS4 Antikörper), -5 and TIMP-3 (zeige TIMP3 Antikörper).
Dissecting the interaction between TIMP3 (zeige TIMP3 Antikörper) and LRP1 using a synthetic analog of the LRP1 receptor has been reported.
FVIIa-antithrombin (zeige SERPINC1 Antikörper) but not FVIIa is a ligand for LRP1, and LRP1 contributes to the clearance of FVIIa-antithrombin (zeige SERPINC1 Antikörper) in vivo
Activated alpha2 -Macroglobulin (zeige A2M Antikörper) Induces Mesenchymal Cellular Migration Of Raw264.7 Cells Through Low-Density Lipoprotein Receptor-Related Protein 1
Study demonstrated that LRP1 expression is significantly upregulated by myeloid cells in active multiple sclerosis lesions in comparison to the surrounding healthy tissue. Results suggest that the function of LRP1 in microglia is to keep these cells in an anti-inflammatory and neuroprotective status during inflammatory insult.
Poor LRP1 expression in T cells depends on shedding. Integrin ligands and CXCL12 (zeige CXCL12 Antikörper) antagonize shedding through a TSP-1 (zeige THBS1 Antikörper)-dependent pathway and ligation of CD28 (zeige CD28 Antikörper) antagonizes shedding independent of TSP-1 (zeige THBS1 Antikörper).
Altered Met receptor phosphorylation and LRP1-mediated uptake in cells lacking carbohydrate-dependent lysosomal targeting
LRP1 single-nucleotide polymorphism is associated with migraine.
Results suggest that LRP1 facilitates NSPCs differentiation via interaction with apolipoprotein E (ApoE (zeige APOE Antikörper)). Upon ApoE4 stimulation wild type neural stem/progenitor cells generated more oligodendrocytes, but LRP1 knockout cells showed no response. The effect of ApoE (zeige APOE Antikörper) seems to be independent of cholesterol uptake, but is rather mediated by downstream MAPK (zeige MAPK1 Antikörper) and Akt (zeige AKT1 Antikörper) activation.
Data suggest that Lrp1 shedding from microglia of cerebral cortex may amplify and sustain neuroinflammation in response to proinflammatory stimuli.
both LRP1 and LDLR (zeige LDLR Antikörper) expression and agLDL uptake are regulated by P2Y2R (zeige P2RY2 Antikörper) in vascular smooth muscle cells, and agLDL uptake due to P2Y2R (zeige P2RY2 Antikörper) activation is dependent upon cytoskeletal reorganization mediated by P2Y2R (zeige P2RY2 Antikörper) binding to FLN-A (zeige FLNA Antikörper)
In experimental autoimmune encephalomyelitis mice lacking LRP1 in microglia or in macrophages, only microglial LRP1 was protective, as animals lacking LRP1 in this compartment experienced a worse clinical outcome. Results suggest that the function of LRP1 in microglia is to keep these cells in an anti-inflammatory and neuroprotective status during inflammatory insult, including experimental autoimmune encephalomyelitis.
Therefore, we concluded that the beneficial effects of LF might be due to an increase of autophagy activity via AMPK (zeige PRKAA1 Antikörper) signaling through the LRP1 receptor. These findings provide a novel insight into the physiological role of LF for the maintenance of cellular and tissue homeostasis.
This study demonstrated that LRP1 suppresses microglial activation by modulating JNK (zeige MAPK8 Antikörper) and NF-kappaB (zeige NFKB1 Antikörper) signaling pathways. Down-regulation of LRP1 levels and the increased pro-inflammatory signaling may result in a vicious cycle, in which the two events synergistically promote microglial activation
ApoC-III (zeige APOC3 Antikörper) inhibits turnover of TG-rich lipoproteins primarily through a hepatic clearance mechanism mediated by the LDLR (zeige LDLR Antikörper)/LRP1 axis
These results provide evidence supporting a key role for the p38 MAPK (zeige MAPK14 Antikörper) signaling pathway which is involved in the regulation of Abeta1-42 internalization in the parietal cortex and hippocampus of mouse through LRP1 in vivo.
BMPER (zeige BMPER Antikörper)/low-density lipoprotein receptor-related protein 1 axis plays a pivotal role in pulmonary inflammatory response.
Even though LRP-1 mRNA and protein levels were dramatically reduced in LRP-1-silenced L6 cells compared with mock-silenced controls, rpIGFPB-3 suppressed proliferation rate to the same extent in both LRP-1-silenced and mock-silenced cultures.
Hypoxia increases LRP1 expression and that LRP1 overexpression mediates hypoxia-induced very low density lipoprotein-cholesteryl ester uptake and accumulation in cardiomyocytes.
Endometrial LRP1 protein expression was specifically high in such cyclic and pregnancy stages.
The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients.
, TbetaR-V/LRP-1/IGFBP-3 receptor
, alpha-2-macroglobulin receptor
, apolipoprotein E receptor
, prolow-density lipoprotein receptor-related protein 1
, type V tgf-beta receptor
, low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)
, low density lipoprotein receptor-related protein 1
, prolow-density lipoprotein receptor-related protein 1-like
, alpha 2-macroglobulin receptor
, lipoprotein receptor-related protein
, low-density lipoprotein receptor-related protein 1
, low-density lipoprotein receptor-related protein/alpha-2 macroglobulin receptor
, LOW QUALITY PROTEIN: prolow-density lipoprotein receptor-related protein 1