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Monomeric Homer 1a proteins increase activity of Imin channels, but did not modulate their electrophysiological properties. Recombinant Homer 1c protein did not block the induced calcium currents.
Study found the common variant rs7713917 in the HOMER1 gene to be significantly associated with suicide attempt in Chinese patient.
Homer 1 rs7713917 gene variant associated with brain structure and function, severity of depression, and antidepressant response in patients affected by a major depressive episode in course of bipolar disorder.
This study demonstrate that altered Homer1a levels in specific brain regions and cell types of patients suffering from schizophrenia, bipolar disorder and major depression.
Study shows that Homer1b/c is constitutively expressed in astrocytes, where it clusters with mGlu5 (zeige GRM5 Proteine) and endoplasmic reticulum tubules to form sub-plasmalemmal microdomains; propose that Homer1a may represent one of the cellular mechanisms by which inflammatory astrocytic reactions are beneficial for limiting brain injury
Homer1 and Homer2 (zeige HOMER2 Proteine) might be considered as novel diagnostic biomarkers for large-artery atherosclerosis stroke.
Resequencing three candidate genes (HOMER1, SLC6A4 (zeige SLC6A4 Proteine), and TEF (zeige TEF Proteine)) discovers seven potentially deleterious variants susceptibility to major depressive disorder and suicide attempts in Chinese.
The present study was undertaken to determine the expression and functional significance of Homer1b/c in multiple myeloma
The main focus of the present review is to offer an overview of the current knowledge about the potential role of Homer1a in depression and the signaling pathways responsible for Homer1a regulation. [review]
The mRNA levels of Homer1, IL-1beta (zeige IL1B Proteine), and TNF-alpha (zeige TNF Proteine) in coronary artery disease patients were significantly higher than those in the control group, but not Homer2 (zeige HOMER2 Proteine) and Homer3 (zeige HOMER3 Proteine).
The authors show that SNX6 (zeige SNX6 Proteine) functions independently of retromer to regulate distribution of Homer1b/c in the dendritic shaft.
All these results showed that Homer1 is involved in t-BHP-induced endothelial dysfunction in mBECs, and may be an ideal candidate for searching gene intervention strategy for preventing endothelial oxidative stress in vitro.
The study showed that Homer1b/c increased in mtSOD1 G93A transgenic mice, which contributes to neuronal apoptosis in amyotrophic lateral sclerosis. The inhibition of Homer1b/c by its siRNA and lithium and valproic acid protected against neuronal apoptosis in amyotrophic lateral sclerosis induced by mtSOD1 G93A.
Homer1a contributes to retinal ganglion cell survival after ischemia/reperfusion injury by interacting with Erk (zeige EPHB2 Proteine) pathway.
Homer1a may be a key neuroprotective endogenous molecule that protects against NMDA-induced neuronal injury by disassembling NR2B (zeige GRIN2B Proteine)-PSD95 (zeige DLG4 Proteine)-nNOS (zeige NOS1 Proteine) complexes and reducing the membrane distribution of NR2B (zeige GRIN2B Proteine).
This study demonstrated that brain stimulations that induce H1a expression may be beneficial to depression.
Results provide compelling evidence for the involvement of the Homer1/mGluR5 (zeige GRM5 Proteine) complex in the emergence and regulation of stress-induced behavioral and neuroendocrine phenotypes
Specific siRNA knockdown of homer 1a in medial prefrontal cortex enhanced depressive-like behavior.
Homer 1a was neuroprotective against traumatic brain injury in vitro and in vivo, and this neuroprotection was associated with its effects on group I metabotropic glutamate (zeige GRIN1 Proteine) receptors.
Results indicate that miR (zeige MYLIP Proteine)-3906 controls [Ca(2 (zeige CA2 Proteine)+)]i homeostasis in fast muscle through fine tuning homer-1b expression during differentiation
The high level of conservation of the xhomer1 gene and the protein expression in the developing nervous system suggest that Homer1 expression may be important for normal neuronal circuit development.
Genetic deletion of Homer in Drosophila results in fragmented sleep and in failure to sustain long bouts of sleep, even under increased sleep drive.
null homer mutant flies exhibit both increased sensitivity to the sedative effects of ethanol and failure to develop normal levels of rapid tolerance
This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function.
homer protein homolog 1
, homer, neuronal immediate early gene, 1
, homer homolog 1 (Drosophila)
, homer 1
, VASP/Ena-related gene up-regulated during seizure and LTP 1
, immediate early gene protein Homer1A
, homer homolog 1
, homer homolog 1b
, scaffold protein
, homer 1b-1
, CG11324 gene product from transcript CG11324-RD
, drosophila Ves-1 homolog