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Taken together, DNER could promote proliferation, migration, and invasion of HCC cells by regulating the activation of PI3K/AKT pathway.
quantum dot-based immunofluorescent imaging and quantitative analytical system (QD-IIQAS) is an easy and accurate method for assessing DNER and the DNER expression was an independent prognostic factor in prostate cancer.
Collectively, our study identified an unexpected transcriptional repression function of the BET bromodomain and a novel mechanism for TAZ upregulation.
our findings show that targeting BET proteins for degradation represents an effective therapeutic strategy for Triple-negative breast cancers (TNBC)treatment
is not a Notch ligand
we review and discuss the structural biology of BET family BDs and their applications in major diseases.
DNER rs1861612 C to T change and variant T genotype may contribute to T2DM in a Chinese Han population
These studies implicate DNER as a susceptibility gene for T2DM in American Indians.
Our data suggest that clathrin-independent endocytosis is critical for the polarized targeting of somatodendritic proteins(DNER).
The inhibition of DNER protein resulted in an increase in adipocyte maturation, partly via a reduction of cell proliferation through elevation of CCAAT-Enhancer-Binding Protein-delta expression.
expression in developing and mature central nervous system
Overall, these studies show that BET proteins may have a critical role in asthma pathogenesis by altering type 17 inflammation.
This study showed that the DNER is present in ganglion and amacrine cells on P1, also labeling the horizontal cells by P10. Developing AII amacrine cells exhibit accumulating DNER labeling at the dendritic stalk, labeling that becomes progressively conspicuous by P10, as it is in maturity.
the present study demonstrated that DNER was expressed in SGNs and appeared to be involved in the mechanisms underlying neuronal polarity and neuritogenesis, via a Notchdependent signaling pathway.
DNER plays a redundant role with other Notch ligands in cochlear development
DNER mediates neuron-glia interaction and promotes morphological differentiation of Bergmann glia through Deltex-dependent Notch signaling.
These observations suggest that pleiotrophin-PTPzeta signaling controls subcellular localization of DNER and thereby regulates neuritogenesis.
Mediates neuron-glia interaction during astrocytogenesis. May promote differentiation of Bergmann glia during cerebellar development by activating DELTEX-dependent NOTCH1 signaling.
delta-notch-like EGF repeat-containing transmembrane
, delta and Notch-like epidermal growth factor-related receptor
, delta/notch-like EGF-related receptor
, brain EGF repeat-containing transmembrane protein
, transmembrane protein Bet