anti-Choline Acetyltransferase (CHAT) Antikörper

Human Choline O-Acetyltransferase (CHAT) Interaktionspartner

1. The SNP rs3753841 in COL11A1, rs1258267 in CHAT and rs736893 in GLIS3 are associated with PACG in northern Chinese people, and the association of genetic markers manifests a tendency of ethnic diversity. Larger population-based studies are warranted to reveal additional primary angle-closure glaucoma loci and ethnic aspects of primary angle-closure glaucoma.

2. CHAT SNP rs12246528 had the strongest association with parahippocampal structure, with the A allele being linked to smaller volume, surface area, and thickness. SNP rs1917814 had the strongest association with hippocampal volume, with the T allele being linked to larger hippocampal volume. CHAT rs3729496 had the strongest association with memory span, with the T allele being associated with a greater memory span.

3. CHAT may contribute to Tourette syndrome susceptibility in the Han Chinese population.

4. the AA genotype of CHAT was associated with a 1.25 times higher risk of Alzheimer's disease (AD) thus demonstrating that the rs3810950 polymorphism can have a modest but statistically significant effect on the risk of AD in the Czech population

5. Compared with the control group, the densitometric quantification and mean density of GPR43 and ChAT proteins, and expression of GPR43 and CHAT genes, were significantly decreased in the patients with mixed refractory constipation.

6. meta-analysis suggested that rs1880670G/A, and rs2177369 G/A polymorphisms were not risk factors for Alzheimer's Disease. However, rs3810950G/A, or rs868750G/A genetic polymorphism was a genetic risk factor for the development of Alzheimer's Disease.

7. Results suggest that SATB1 is activated to bind to chromatin at S/MARs after exposure to Abeta 1-42, resulting in alternative utilization and movement of 82-kDa ChAT to these regions demonstrating that both proteins play critical roles in the response of neural cells to acute Abeta-exposure.

8. We conducted a meta-analysis of studies involving CHAT, TFAM, and VR22 polymorphisms and Alzheimer disease susceptibility.For CHAT, rs2177369 (G>A) in whites and rs3810950 (G>A) in Asians were found to be associated with AD susceptibility. No association was detected between rs1880676 and rs868750 and AD risk.

9. In conclusion, our meta-analysis indicated CHAT rs2177369 polymorphism might play a protective role in AD, while rs3810950 variant was a risk factor for AD but its single heterozygous mutations might not influence susceptibility to AD.

10. Two novel CHAT gene mutations, p.Val306Leu and p.Ser704del were detected in an ethnic Kadazandusan family with congenital myasthenic syndrome.

11. sequence variants of CHAT were associated with human cognitive ability in not only patients with psychiatric disorders but also normal healthy individuals

12. There is a striking variability in the severity of phenotypes resulting from mutations in CHAT, which is the only gene so far known to be linked with congenital deficiency of ACh synthesis.

13. Data show thata the expression of choline acetyltransferase (ChAT) is reduced in the postmortem alcoholic basal forebrain in comparison to moderate drinking controls.

14. This study confirmed that genetic polymorphism of CHAT has an influence on drug response in Alzheimer's disease.

15. These studies indicate a novel relationship between cholinergic neurons and APP processing, with 82-kDa ChAT acting as a negative regulator of Abeta production

16. The results demonstrate that human NSCs over-expressing ChAT improve cognitive function and physical activity of aging mice.

17. rs1880676 is functional and the allelic variations of this polymorphism are involved in developing nicotine dependence by altering ChAT expression.

18. There was a loss of choline O-acetyltransferase in the visual cortex of dementia with Lewy bodies patients.

19. There were CHAT mRNA reactions in the synovial lining layer in patients with rheumatoid arthritis and osteoarthritis.

20. In airway epithelial cells anti-CHAT immunogold was found particularly within the apical cell membrane, cilia, submucosa, cytosol and nuclear membrane.

Zebrafish Choline O-Acetyltransferase (CHAT) Interaktionspartner

1. Mutation of a serine near the catalytic site of the choline acetyltransferase a gene almost completely abolishes motility of the zebrafish embryo

2. We have identified a zebrafish mutant line, bajan, in which compromised motility and fatigue result from a point mutation in the gene coding choline acetyltransferase

Pig (Porcine) Choline O-Acetyltransferase (CHAT) Interaktionspartner

1. The results revealed broad coexistence of ChAT and CGRP in the spinal cord neurons which implies that the neurons synthesize and store ChAT and CGRP in their cell bodies.

Mouse (Murine) Choline O-Acetyltransferase (CHAT) Interaktionspartner

1. The numbers of nAChR alpha4 immuno-positive cells and western blot levels were significally increased by 15-Hz auricular electrical stimulation in the hippocampal CA2 output cortex. The numbers of choline acetyltransferase (ChAT) - a key enzyme for biosynthesis of ACh - immuno-positive cells and western blot levels had no significant differences.

2. These results suggest that ChAT, CGRP, and KCC2 may be objective indicators of nerve regeneration, and altering their expression may be related to the functional recovery and axonal re-extension.

3. Lmna gene product might play a crucial role in the ChAT-dependent molecular differentiation cascade.

4. cholinergic transmission in the knock-out dorsal motor nucleus of vagus was overactivated because knock-out mice lack CPEB2-suppressed translation of the rate-limiting enzyme in the production of acetylcholine (i.e., choline acetyltransferase)

5. Study describes in detail a population of choline acetyltransferase immunoreactive /glutamate decarboxylase 67 neurons predominantly ventral to the central canal of the cervical, thoracic and lumbar spinal cord of adult and juvenile mice. These cells potentially correspond to a sub-population of the cholinergic central canal cluster cells which may play a unique role in controlling spinal cord circuitry.

6. The isolation and characterization of CD4 TChAT cells will enable analysis of the role of these cells in hypotension and hypertension, and may suggest novel therapeutic strategies by targeting cell-mediated vasorelaxation.

7. American ginseng extract (Cereboosttrade mark) administration recovered the cognitive function of Alzheimer disease model animals by enhancing acetylcholine level via ChAT gene expression and neuroprotection.

8. Microgravity causes substantial down-regulation of nerve tissue proteins, choline acetyltransferase, NF200, and calbindin in mouse motor neurons.

9. These studies indicate a novel relationship between cholinergic neurons and APP processing, with 82-kDa ChAT acting as a negative regulator of Abeta production

10. increased REST/NRSF expression and its effect on the regulatory region for choline acetyltransferase (ChAT) transcription could explain the decreased expression of ChAT in the Alzheimer's disease transgenic mouse

11. Optogenetic inhibition and stimulation of subependymal ChAT(+) neurons in vivo indicated that they were necessary and sufficient to control neurogenic proliferation

12. This study found sparse innervation in the spleen consisting of neuronal fibers of spinal origin present around arterioles and in lymphocyte-containing areas of the white pulp.

13. Cognitive deficits are accompanied by down-regulation of ChAT mRNA expression on day 5 and 11 post-immunization and up-regulation of inflammatory cytokines in autoimmune encephalitis.

14. This study shows that cholinergic neurons in the ENS develop over a protracted period of time.

15. chronic social defeat stress in mice produces stress-related behaviors; a decrease in the Chat level at days 12 and 27 was noted in the prefrontal cortex (PFC), amygdala (Amyg), and dorsal hippocampus (HIP) in defeated mice

16. In choline acetyltransferase transgenic mice the activated cardiac ACh-HIF-1alpha cascade improves survival after myocardial infarction.

17. Our studies demonstrate that ChAT-ChR2 mice show altered cholinergic tone that fundamentally differentiates them from wild-type mice

18. After bilateral common carotid artery occlusion, peripherin overexpression was significantly correlated with reduction in ChAT activity

19. In the murine embryonic stem cell line CGR8 positive anti-ChaT immunogold was identified within the cell nucleus and cytosol.

20. Histone deacetylase 9 (HDAC9) represses ChAT gene expression in NG108-15 neuronal cells and thus plays an important role in cholinergic differentiation.

Rabbit Choline O-Acetyltransferase (CHAT) Interaktionspartner

1. CS and SERCA activities were significantly higher in the pubococcygeus (Pc) compared with the ischiocavernosus/bulbospongiosus (Ic/Bs) pelvic floor muscles, whereas the ChAT activity of the Ic/Bs was higher than that of the Pc muscle.