anti-Tricellulin (MARVELD2) Antikörper

Mouse (Murine) Tricellulin (MARVELD2) Interaktionspartner

1. Findings suggest that both tricellular tight junctions proteins TRIC and LSR (zeige LSR Antikörper) have crucial roles for the differentiated cochlear cell survival.

2. Tricellulin is a specific redox sensor and sealing element at 3-cell contacts and may compensate as a redox mediator for occludin (zeige OCLN Antikörper) loss at 2-cell contacts in vivo and in vitro.

3. GFP-tagged angulin-1/LSR (zeige LSR Antikörper), in which serine 288 was substituted by alanine, was observed to be dispersed to bicellular junctions, indicating that phosphorylation of Ser288 is crucial for the exclusive localization of angulin-1/LSR (zeige LSR Antikörper) and tricellulin at tTJs.

4. localization of angulin-1/LSR (zeige LSR Antikörper) and tricellulin at tricellular contacts of brain and retinal endothelial cells in vivo

5. Loss of tricellulin prevented the coalition of the strands of the bicellular junction with the central element of the tricellular junction in the inner ear epithelia.

6. The findings show the heterogeneity of the molecular organization of tTJs in terms of the content of LSR (zeige LSR Antikörper), ILDR1 (zeige ILDR1 Antikörper) or ILDR2, and suggest that ILDR1 (zeige ILDR1 Antikörper)-mediated recruitment of tricellulin to TCs is required for hearing.

7. The tricellulin may be a component to maintain the integrity for PNS myelin function and morphology.

8. marvelD3 (zeige MARVELD3 Antikörper), occludin (zeige OCLN Antikörper), and tricellulin define the tight junction-associated MARVEL protein family

9. In this study, we identify tricellulin, the first integral membrane protein that is concentrated at the vertically oriented TJ strands of tricellular contacts.

10. In the inner ear, tricellulin is concentrated at the tricellular tight-junctions in cochlear and vestibular epithelia, including the structurally complex and extensive junctions between supporting and hair cells.

Human Tricellulin (MARVELD2) Interaktionspartner

1. Our results provide new insights into the function of tricellulin, and its nuclear localization may become a new prognostic factor for pancreatic cancers.

2. GSK3beta may inhibit VRK2 (zeige VRK2 Antikörper) catalytic activity by disrupting its flexibility. The inhibition of VRK2 (zeige VRK2 Antikörper) catalytic activity by GSK3beta may also inhibit VRK2 (zeige VRK2 Antikörper)-induced degradation of TRiC, which could suppress polyQ-expanded Htt (zeige HTT Antikörper) aggregation.

3. Tricellulin-dependent macromolecule passage was comparably regulated in leaky and tight epithelia, but relative and absolute ion permeabilities of the tricellular tight junction (tTJ) were different.

4. Data show that the E3 ubiquitin ligase (zeige MUL1 Antikörper) Itch forms a complex with tricellulin and thereby enhances its ubiquitination.

5. we demonstrated that PLG (zeige PLG Antikörper) functions as a molecular bridge between tricellulin and streptococcal surface enolase (SEN (zeige MORF4 Antikörper)). The wild type strain efficiently translocated across the epithelial monolayer, accompanied by cleavage of transmembrane junctional proteins.

6. The expressions of MARVELD2, CLDN1 (zeige CLDN1 Antikörper) and CLDN3 (zeige CLDN3 Antikörper) mRNA were significantly lower in cholesteatoma tissue and may be involved in epithelium permeability.

7. High tricellulin expression is associated with hepatocellular carcinoma.

8. MARVELD2 variants are responsible for about 1.5 % (95 % CI 0.8-2.6) of non-syndromic hearing loss in our cohort of 800 Pakistani families. The c.1331+2T>C allele is recurrent.

9. The findings show the heterogeneity of the molecular organization of tTJs in terms of the content of LSR (zeige LSR Antikörper), ILDR1 (zeige ILDR1 Antikörper) or ILDR2, and suggest that ILDR1 (zeige ILDR1 Antikörper)-mediated recruitment of tricellulin to TCs is required for hearing.

10. This study reveals the presence and subcellular distribution of tricellulin in brain endothelial cells.