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For those with a combination of severely pathogenic TMPRSS3 (zeige TMPRSS4 Proteine) variants, rapid aggravation of the residual hearing should be anticipated and treated accordingly. Our confirmation of the genotype-phenotype correlation of the TMPRSS3 (zeige TMPRSS4 Proteine) gene may pave the way for the establishment of a personalized auditory rehabilitation.
Our results indicate that mutations in TMPRSS3 (zeige TMPRSS4 Proteine) account for about 4.6% (7/151) of Chinese autosomal recessive nonsyndromic hearing loss cases lacking mutations in SLC26A4 (zeige SLC26A4 Proteine) or GJB2 (zeige GJB2 Proteine) and that the recurrent TMPRSS3 (zeige TMPRSS4 Proteine) mutation p.Ala306Thr is likely to be a founder mutation.
Given that a previous paper suggested TMPRSS3 (zeige TMPRSS4 Proteine) and GJB2 (zeige GJB2 Proteine) genes as responsible for a digenic form of hearing loss, our data support and reinforce this hypothesis.
In conclusion, TMPRSS3 (zeige TMPRSS4 Proteine) and TNFRSF11B (zeige TNFRSF11B Proteine) may have potential prognostic value to be used as tumor biomarkers in breast cancer patients.
different combinations of TMPRSS3 (zeige TMPRSS4 Proteine) mutations led to different hearing impairment phenotypes (DFNB8/DFNB10) in the Chinese family.
TMPRSS3 (zeige TMPRSS4 Proteine) mutations seem to be an important cause of autosomal recessive nonsyndromic hearing loss in Slovenia resulting in rather uniform phenotype with profound congenital hearing loss.
Study demonstrated that TMPRSS3 contributes to ovarian cancer cell proliferation, invasion and metastasis, probably via activation of the ERK1/2 signaling pathway.
TMPRSS3 (zeige TMPRSS4 Proteine) expression is an independent prognostic factor for breast cancer patients. Bioinformatic analysis of potential TMPRSS3 (zeige TMPRSS4 Proteine) binding proteins revealed that TMPRSS3 (zeige TMPRSS4 Proteine) could be a key regulator of cancer pathways.
Low expression levels of hepsin (zeige HPN Proteine) and TMPRSS3 (zeige TMPRSS4 Proteine) are associated with poor breast cancer survival
Single nucleotide polymorphisms in TMPRSS3 (zeige TMPRSS4 Proteine) (rs3814903 and rs11203200) are significantly associated with breast cancer risk.
miR (zeige MLXIP Proteine)-204 has a role in suppressing cochlear spiral ganglion neuron survival in vitro by targeting TMPRSS3
Lack of Tmprss3 leads to a decrease in Kcnma1 (zeige KCNMA1 Proteine) potassium channels expression in cochlear inner hair cells.
The distribution of TMPRSS3 was observed in many regions of the mouse cochlea, but mainly in the spiral ganglion neurons.
Tmprss3 acts as a permissive factor for cochlear hair cells survival and activation at the onset of hearing and is required for saccular hair cell survival
This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, an LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor-associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described.
transmembrane protease, serine 3
, transmembrane protease serine 3-like
, serine protease TADG-12
, transmembrane protease serine 3
, tumor-associated differentially-expressed gene 12 protein
, transmembrane proteinase serine 3