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we introduce the molecular mechanism by which flavonoids, specifically quercetin, act through elevation of [Cl(-) ]c via activation of NKCC1 on important factors controlling various body and cellular functions, such as (1) antihypertensive actions controlling blood volume dependent on the amounts of renal Na(+) reabsorption via expression of the epithelial Na(+) channel
NKCC1 and KCCs are coordinately regulated by L-WNK1 (zeige WNK1 Proteine) isoforms.
We also discovered and replicated three genome-wide significant variants in previously unreported loci for RDW (SLC12A2 rs17764730, PSMB5 (zeige PSMB5 Proteine) rs941718), and hematocrit (PROX1 (zeige PROX1 Proteine) rs3754140) and an upstream anti-sense long-noncoding RNA, LINC01184, as the likely causal variant
NKCC1 high expression predicted a bad clinical outcome for lung adenocarcinoma patients and EGFR (zeige EGFR Proteine)-mutated subgroup. Therefore, NKCC1 may play a role in lung adenocarcinoma and novel therapeutic tactics could be developed by targeting NKCC1 protein.
Study describes a functional missense variant in SLC12A2 in human schizophrenia, and suggest that genetically encoded dysregulation of NKCC1 may be a risk factor for, or contribute to the pathogenesis of, schizophrenia
The NKCC-1 is a Na(+)- dependent Cl(-) transporter that mediates the movement of Na(+), K(+), and Cl(-) ions across the plasma membrane and maintains cell volume and intracellular K(+) and Cl(-) homeostasis.
NKCC1 labeling was seen only in the basolateral membrane of the secretory coils.
Suggest that the expression of NKCC1 in esophageal squamous cell carcinoma may affect the G2/M checkpoint and may be related to the degree of histological differentiation of SCCs.
Functional expression of human NKCC1 from a synthetic cassette-based cDNA: introduction of extracellular epitope tags and removal of cysteines.
our data show a novel role for the WNK1 (zeige WNK1 Proteine)/OSR1 (zeige OXSR1 Proteine)/NKCC1 pathway in glioma migration
Study showed that there is a transient dysregulation in the levels of NKCC1 and KCC2 (zeige SLC12A5 Proteine) at disease onset, the time point when heightened nociceptive behaviors are most pronounced in mice with experimental autoimmune encephalomyelitis.
This study identify neuronal up-regulation of NKCC1 and its mediation by TGFbeta (zeige TGFB1 Proteine), as a potential and important mechanism in the early post-traumatic seizures, and demonstrate the therapeutic potential of blocking this pathway.
Study suggests that astaxanthin may exert neuroprotection following traumatic brain injury by ameliorating AQP4 (zeige AQP4 Proteine)/NKCC1-mediated cerebral edema, and NKCC1 inactivation inhibitions the upregulation of AQP4 (zeige AQP4 Proteine) after traumatic brain injury.
GABAA (zeige GABRg1 Proteine) receptor (GABAAR (zeige GABRG2 Proteine)) and the Na(+)-K(+)-2Cl(-) cotransporter (zeige SLC12A1 Proteine) (NKCC1), but not the K(+)-Cl(-) cotransporter (zeige SLC12A4 Proteine) (KCC2 (zeige SLC12A5 Proteine)), were expressed in the terminals of the CRH (zeige CRH Proteine) neurons at the median eminence (ME). In contrast, CRH (zeige CRH Proteine) neuronal somata were enriched with KCC2 (zeige SLC12A5 Proteine) but not with NKCC1.
These results identify NKCC1 as a novel target for Nedd4L (zeige NEDD4L Proteine)-mediated down-regulation in vivo, which modulates ion and fluid transport in the distal colon together with epithelial Na(+) channel (ENaC (zeige SCNN1A Proteine)).
NKCC1 inhibition protects neurons from traumatic brain injury via regulation of the ERK (zeige EPHB2 Proteine) signal pathway.
We conclude that TRPV2 (zeige TRPV2 Proteine) is involved in osmosensation in skeletal muscle fibres, acting in concert with P-SPAK (zeige STK39 Proteine)-activated NKCC1
KCC2 (zeige SLC12A5 Proteine) expression supersedes NKCC1 in mature fiber cells in mouse and rabbit lenses.
GnRH (zeige GNRH1 Proteine) neurons were immunopositive for NKCC1 and AE2 (zeige SLC4A2 Proteine).
NKCC1 may have a role in periventricular leukomalacia, as shown by bumetanide protection against white matter injury in a rodent model
The protein encoded by this gene mediates sodium and chloride transport and reabsorption. The encoded protein is a membrane protein and is important in maintaining proper ionic balance and cell volume. This protein is phosphorylated in response to DNA damage. Three transcript variants encoding two different isoforms have been found for this gene.
solute carrier family 12 (sodium/potassium/chloride transporters), member 2
, solute carrier family 12 member 2-like
, basolateral Na-K-Cl symporter
, bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1
, solute carrier family 12 member 2
, solute carrier family 12, member 2
, basolateral NaK(2Cl) cotransporter
, sodium/potassium/chloride cotransporters
, sodium/potassium/chloride transporters