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NKCC1 not only controls cell volume and Cl- concentration, but it can also regulate the actin cytoskeleton through Cofilin 1.
This new functional assay offered a robust working model for NKCC1 in determining reliable and concordant rank orders of the test compounds supporting its sensitivity and specificity.
we introduce the molecular mechanism by which flavonoids, specifically quercetin, act through elevation of [Cl(-) ]c via activation of NKCC1 on important factors controlling various body and cellular functions, such as (1) antihypertensive actions controlling blood volume dependent on the amounts of renal Na(+) reabsorption via expression of the epithelial Na(+) channel
NKCC1 and KCCs are coordinately regulated by L-WNK1 isoforms.
We also discovered and replicated three genome-wide significant variants in previously unreported loci for RDW (SLC12A2 rs17764730, PSMB5 rs941718), and hematocrit (PROX1 rs3754140) and an upstream anti-sense long-noncoding RNA, LINC01184, as the likely causal variant
NKCC1 high expression predicted a bad clinical outcome for lung adenocarcinoma patients and EGFR-mutated subgroup. Therefore, NKCC1 may play a role in lung adenocarcinoma and novel therapeutic tactics could be developed by targeting NKCC1 protein.
Study describes a functional missense variant in SLC12A2 in human schizophrenia, and suggest that genetically encoded dysregulation of NKCC1 may be a risk factor for, or contribute to the pathogenesis of, schizophrenia
The NKCC-1 is a Na(+)- dependent Cl(-) transporter that mediates the movement of Na(+), K(+), and Cl(-) ions across the plasma membrane and maintains cell volume and intracellular K(+) and Cl(-) homeostasis.
NKCC1 labeling was seen only in the basolateral membrane of the secretory coils.
Suggest that the expression of NKCC1 in esophageal squamous cell carcinoma may affect the G2/M checkpoint and may be related to the degree of histological differentiation of SCCs.
Functional expression of human NKCC1 from a synthetic cassette-based cDNA: introduction of extracellular epitope tags and removal of cysteines.
our data show a novel role for the WNK1/OSR1/NKCC1 pathway in glioma migration
NKCC activation involves movement of TM12 relative to TM10, which is likely tied to movement of the large C terminus
Reduced KCC2/NKCC1 ratio in the cerebrospinal fluid of Rett Syndrome patients suggests a disturbed process of GABAergic neuronal maturation and open up a new therapeutic perspective.
The hormone aldosterone was found to upregulate NKCC1 by increasing protein stability.
The rs10089 single nucleotide polymorphism was associated with increased susceptibility to noise-induced hearing loss.
Altered hippocampal area function and coupling in DISC1 and SLC12A2 minor allele carriers.
The results indicate a role for COMMD1 in the regulation of NKCC1 membrane expression and ubiquitination.
These findings suggest that NKCC1 and AQP1 participate in meningioma biology and invasion
A significant association is found between single nucleotide polymophisms in SLC12A2 and CTXN3 and schizophrenia in a Thai population.
The protein encoded by this gene mediates sodium and chloride transport and reabsorption. The encoded protein is a membrane protein and is important in maintaining proper ionic balance and cell volume. This protein is phosphorylated in response to DNA damage. Three transcript variants encoding two different isoforms have been found for this gene.
solute carrier family 12 (sodium/potassium/chloride transporters), member 2
, solute carrier family 12 member 2-like
, basolateral Na-K-Cl symporter
, bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1
, solute carrier family 12 member 2
, solute carrier family 12, member 2
, basolateral NaK(2Cl) cotransporter
, sodium/potassium/chloride cotransporters
, sodium/potassium/chloride transporters