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Human Polyclonal SCO1 Primary Antibody für IHC, ELISA - ABIN1003126
Glerum, Shtanko, Tzagoloff: SCO1 and SCO2 act as high copy suppressors of a mitochondrial copper recruitment defect in Saccharomyces cerevisiae. in The Journal of biological chemistry 1996
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Human Polyclonal SCO1 Primary Antibody für ICC, IF - ABIN4352258
Rolland, Motori, Memar, Hench, Frank, Winklhofer, Conradt: Impaired complex IV activity in response to loss of LRPPRC function can be compensated by mitochondrial hyperfusion. in Proceedings of the National Academy of Sciences of the United States of America 2013
data suggest that c-Kit (zeige KIT Antikörper) negatively regulates bone turnover, and disrupted c-Kit (zeige KIT Antikörper) signaling couples increased bone resorption with bone formation through osteoclast-derived Wnt (zeige WNT2 Antikörper) 10 b
Data collectively argue that mutations perturbing SCO1 function have tissue-specific consequences for the machinery that ultimately governs copper homeostasis, and further establish the importance of aberrant mitochondrial signaling to the etiology of copper handling disorders.
After intestinal myenteric plexus ablation with benzalkonium chloride, adult neurogenesis was significantly induced in c-kit (zeige KIT Antikörper) loss-of-function mutant mice (W/W(v)). Imatinib induced appearance of ectopic neurons after BAC treatment, even in wildtype mice. Adult neurogenesis in the enteric nervous system is negatively regulated by c-Kit (zeige KIT Antikörper) signaling in vivo.
This study indicated that c-Kit (zeige KIT Antikörper) could be used as a potential therapeutic target for treatment of cardiac fibrosis.
Activation of c-kit (zeige KIT Antikörper) signalling by SCF (zeige KITLG Antikörper) promotes migration of cardiac stem cells with increased phosphorylation of CXCR4 (zeige CXCR4 Antikörper)-serine 339, p38 mitogen-activated protein kinase (p38 MAPK (zeige MAPK14 Antikörper)) and extracellular regulated protein kinases 1/2 (ERK1/2).
c-Kit (zeige KIT Antikörper)(+) Adipose tissue-derived mesenchymal stem cells (ASCs)may promote breast cancer growth and angiogenesis by a synergistic effect of c-Kit (zeige KIT Antikörper) and IL-3 (zeige IL-3 Antikörper). Our findings suggest that c-Kit (zeige KIT Antikörper)(+) subpopulations of ASCs should be eliminated in fat grafts for breast reconstruction of cancer patients following mastectomy.
exposure of HSPCs to SCF (zeige KITLG Antikörper) and diminished number of c-Kit (zeige KIT Antikörper) receptors in their cell membranes do not compromise the capacity of HSPCs to reconstitute damaged hematopoietic tissue.
the stem cell gene Kit is regulated inversely from Krt5 (zeige KRT5 Antikörper)/Krt14 (zeige KRT14 Antikörper) by RA signaling
TPO (zeige THPO Antikörper) and its receptor Mpl (zeige MPL Antikörper) are dispensable for platelet survival in adult mice
Artificially applied c-kit (zeige KIT Antikörper)(+) cells interact with the target organ endothelium following ischemia reperfusion injury. This interaction seems to depend on TLR-MyD88 (zeige MYD88 Antikörper) signaling.
Results find that COA6 associates with COX2 (zeige COX2 Antikörper) and is crucial for its maturation and complex IV biogenesis. Also, COA6 interacts with the copper chaperone SCO1 which indicates that COA6 is intrinsically involved in the copper delivery process for COX2 (zeige COX2 Antikörper).
Sco1 is a metallochaperone that selectively transfers Cu(I) ions based on loop recognition, whereas Sco2 is a copper-dependent thiol reductase of the cysteine ligands in the oxidase.
COX20 cooperates with SCO1 and SCO2 (zeige SCO2 Antikörper) to mature COX2 (zeige COX2 Antikörper) and promote the assembly of cytochrome c (zeige CYCS Antikörper) oxidase.
COX19 (zeige COX19 Antikörper) is necessary for the transduction of a SCO1-dependent mitochondrial redox signal that regulates ATP7A (zeige ATP7A Antikörper)-mediated cellular copper efflux.
Results describe the tissue distribution of SCO1 and SCO2 in mouse and human tissues.
SCO1 facilitates the transfer of copper from SCO2 (zeige SCO2 Antikörper) to the CuA site at an early stage of COX (zeige COX8A Antikörper) assembly in mitochondria.
data suggest that both Cu(I) and Cu(II) binding are critical for normal Sco (zeige SNAI1 Antikörper) function.
Cox17-mediated copper metallation of Sco1, as well as the subsequent failure of Cu(A) site maturation, is the basis for the inefficient assembly of the cytochrome c oxidase complex in SCO1 patients
Sco1 has evolved to bind a metal atom via the di-Cys (zeige DNAJC5 Antikörper) motif to act as a copper chaperone, the oxidized form of the nickel-bound protein suggests that it may also maintain the thioredoxin (zeige TXN Antikörper) function.
These results suggest a mitochondrial pathway for the regulation of cellular copper content that involves signaling through SCO1 and SCO2, perhaps by their thiol redox or metal-binding state.
Mammalian cytochrome c oxidase (COX) catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. In yeast, 2 related COX assembly genes, SCO1 and SCO2 (synthesis of cytochrome c oxidase), enable subunits 1 and 2 to be incorporated into the holoprotein. This gene is the human homolog to the yeast SCO1 gene.
Dominant white spotting
, Steel Factor Receptor
, c-kit proto-oncogene protein
, dominant spotting
, mast/stem cell growth factor receptor Kit
, proto-oncogene c-Kit
, proto-oncogene tyrosine-protein kinase Kit
, spotted sterile male
, tyrosine-protein kinase Kit
, protein SCO1 homolog, mitochondrial
, SCO cytochrome oxidase deficient homolog 1