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mitochondrial ribosomal protein S12 3'-UTR interacts specifically with TRAP1 (zeige TRAP1 Proteine) (tumor necrosis factor (zeige TNF Proteine) receptor-associated protein1), hnRNPM4 (zeige HNRNPM Proteine) (heterogeneous nuclear ribonucleoprotein (zeige PCBP2 Proteine) M4), Hsp70 (zeige HSP70 Proteine) and Hsp60 (zeige HSPD1 Proteine) (heat shock proteins 70 and 60), and alpha-tubulin (zeige TUBA4A Proteine)
NF-Y type CCAAT boxes are found preferentially in bidirectional Mrps12/Sarsm (zeige SARS2 Proteine) promoters, but many such promoters lack them and must be regulated in another way.
Homo sapiens mitochondrial ribosomal protein S12
Identification of an array of 4 CCAAT box elements required for efficient transcription of the Mrps12 gene.
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S12P family. The encoded protein is a key component of the ribosomal small subunit and controls the decoding fidelity and susceptibility to aminoglycoside antibiotics. The gene for mitochondrial seryl-tRNA synthetase is located upstream and adjacent to this gene, and both genes are possible candidates for the autosomal dominant deafness gene (DFNA4). Splice variants that differ in the 5' UTR have been found for this gene\; all three variants encode the same protein.
28S ribosomal protein S12, mitochondrial
, mitoribosomal protein s12
, ribosomal protein, mitochondrial, S12
, mitochondrial ribosomal protein S12
, mitoribosomal protein S12
, Mitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal proteins
, likely mitochondrial ribosomal protein S12