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TNIK (Traf2 and Nck-interacting kinase (zeige TNIK Proteine)) and MINK (Misshapen/NIKs-related kinase) MAP4K signalling kinases are integral components of both canonical and non-canonical pathways in Xenopus.
KCNE1/KCNQ1 (zeige KCNQ1 Proteine) was expressed in Xenopus oocytes with and without beta-catenin (zeige CTNNB1 Proteine). Confocal microscopy revealed that beta-catenin (zeige CTNNB1 Proteine) enhanced the KCNE1/KCNQ1 (zeige KCNQ1 Proteine) protein abundance in the cell membrane.
PIP(2) has a role in KCNE1 modulation of I(Ks) channels that may represent a common mechanism of auxiliary subunit modulation of many ion channels
characterize a new component of the early bioelectrical circuit: the potassium channel (zeige KCNAB2 Proteine) KCNQ1 (zeige KCNQ1 Proteine) and its accessory subunit KCNE1
phenylboronic acid (PBA) activates KCNQ1 (zeige KCNQ1 Proteine)/KCNE1 complexes
Western blotting analysis combined with these pharmacological data suggest that long-term insulin (zeige INS Proteine) treatment augments KCNQ1 (zeige KCNQ1 Proteine)/KCNE1 currents by increasing KCNE1 protein expression.
KCNQ1/KCNE1 channel does not require phosphatidylinositol-4,5-bisphosphate (PIP2) or phosphatidylinositol-4-phosphate for anterograde trafficking, but is heavily reliant on PIP2 for channel function once at the plasma membrane.
The genetic variant rs426496 in AQP2 (zeige AQP2 Proteine); rs591810 in AQP3 (zeige AQP3 Proteine) and rs1805127, rs1805128, and rs17173510, in KCNE1 were found in patients with Meniere's disease
Meta-analysis suggests that the G38S polymorphism in the KCNE1 gene can significantly increase the risk of atrial fibrillation in both Chinese and white individuals.
Sphingomyelin synthase 1 (zeige SGMS1 Proteine) positively regulates KCNQ1 (zeige KCNQ1 Proteine)/KCNE1 channel density in a protein kinase D (zeige PRKD1 Proteine)-dependent manner.
Receptor Species-dependent Desensitization Controls KCNQ1 (zeige KCNQ1 Proteine)/KCNE1 K+ Channels as Downstream Effectors of Gq Protein-coupled Receptors.(
KCNE1 encodes a modulator of KCNQ1 (zeige KCNQ1 Proteine) and KCNH2 (zeige KCNH2 Proteine) channels. Long QT syndrome (LQTS) patients with KCNE1(G38S) had a rate-dependent repolarization abnormality similar to patients with LQT2 (zeige KCNH2 Proteine) and, therefore, may have a potential risk to develop lethal arrhythmias.
A stoichiometry of 4:4 between the alpha KCNE1 and the beta KCNQ1 (zeige KCNQ1 Proteine)-subunits has been established.
Analysis of QT-RR relationship could also evaluate the latent arrhythmogenicity of KCNE1(G38S).
The incidence of AF among the senior Uygur population in Xinjiang territory was correlated with the KCNE1 (G38S) polymorphism, which may be an independent risk factor for Uygur AF patients.
study demonstrated that in the left ventricle,the level of the transcriptional product of KCNE1 was significantly higher than those of KCNQ1 (zeige KCNQ1 Proteine), KCNH2 (zeige KCNH2 Proteine), and KCNE2 (zeige KCNE2 Proteine)
miR-1 by anti-miR-1 inhibitor oligonucleotides alleviated the downregulation of KCNE1 and KCNB2 (zeige KCNB2 Proteine), the shortening of AERP, and the increase in the IKs
The localization of KCNE1 in the RPE (zeige RPE Proteine) basal membrane, where KCNQ5 (zeige KCNQ5 Proteine) was previously found to be present, suggests that this beta-subunit (zeige POLG Proteine) may contribute to M-type K(+) channels in this membrane.
The electrophysiological effects of BACE1 (zeige BACE Proteine) on KCNQ1 (zeige KCNQ1 Proteine) reported here were independent of its enzymatic activity.
KCNE1 and KCNE3: The yin and yang of voltage-gated K(+) channel (zeige KCND3 Proteine) regulation
KCNE1 and KCNE2 (zeige KCNE2 Proteine), auxiliary subunits of voltage-gated potassium channels, undergo sequential cleavage mediated by either alpha-secretase and presenilin(PS)/gamma-secretase or BACE1 (zeige BACE Proteine) and PS/gamma-secretase in cells.
In clearance studies the KCNE1 knockout mice had an increased fractional excretion of Na+, Cl-, HCO3(-) and water.
This study confirmed that KCNE1 channels are necessary for K+ secretion in developmental Saccule and Utricle in mice.
both the voltage-dependence and kinetics of gating were found to depend on the relative densities of KCNQ1 (zeige KCNQ1 Proteine) and KCNE1, suggesting the heart rhythm may be regulated by the relative expression of the auxiliary subunit
Findings directly implicate triggered electrical activity and spatial and temporal re-entrant mechanisms in the arrhythmogenesis observed in KCNE1 (-/-) hearts.
intestinal Cl(-) secretion is independent from KCNE1 but requires KCNQ1 (zeige KCNQ1 Proteine) and in mouse pancreatic acini KCNQ1 (zeige KCNQ1 Proteine) probably co-assembled with KCNE1 leads to a voltage-dependent K(+) current that might be of importance for electrolyte and enzyme secretion.
the spatial expression of minK-lacZ (zeige GLB1 Proteine) in the adult mouse heart has been shown, for the larger part, to be coincident with the conduction tissues
The transitory transfection of kcne1 restores both Cl- and K+ swelling-activated currents, confirming the implication of KCNE1 protein in the cell-volume regulation in PCT (zeige UROD Proteine) cells in primary cultures.
The product of this gene belongs to the potassium channel KCNE family. Potassium ion channels are essential to many cellular functions and show a high degree of diversity, varying in their electrophysiologic and pharmacologic properties. This gene encodes a transmembrane protein known to associate with the product of the KVLQT1 gene to form the delayed rectifier potassium channel. Mutation in this gene are associated with both Jervell and Lange-Nielsen and Romano-Ward forms of long-QT syndrome. Alternatively spliced transcript variants encoding the same protein have been identified.
potassium voltage-gated channel, Isk-related family, member 1
, voltage-gated potassium channel subunit MinK
, potassium voltage-gated channel subfamily E member 1
, IKs producing slow voltage-gated potassium channel subunit beta Mink
, cardiac delayed rectifier potassium channel protein
, delayed rectifier potassium channel subunit IsK
, minimal potassium channel
, potassium voltage-gated channel, Isk-related subfamily, member 1
, voltage gated potassiun channel accessory subunit
, potassium (K+) channel protein, slowly activating (Isk)
, potassium voltage-gated channel Shaw-related subfamily member 1
, delayed rectifier potassium channel protein
, slow delayed rectifier K+ channel
, voltage gated potassium channel accessory subunit cardiac splice