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anti-Mouse (Murine) GJB6 Antikörper:
anti-Rat (Rattus) GJB6 Antikörper:
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Cow (Bovine) Polyclonal GJB6 Primary Antibody für ELISA - ABIN4300003
Belguith, Tlili, Dhouib, Ben Rebeh, Lahmar, Charfeddine, Driss, Ghorbel, Ayadi, Masmoudi: Mutation in gap and tight junctions in patients with non-syndromic hearing loss. in Biochemical and biophysical research communications 2009
Results demonstrate that Cx43 (zeige GJA1 Antikörper), but not Cx30, is crucial for adult neurogenesis in the hippocampus.
Cochlea in Cx26(+/-)/Cx30(+/-) mice displayed normal development and had no apparent hair cell degeneration. Double heterozygous deletion of Cx26 (zeige GJB2 Antikörper) and Cx30 in the epithelial cells did not reduce endocochlear potential and had normal hearing, suggesting that Cx26(+/-)/Cx30(+/-) may mainly impair gap junctional functions in the cochlear lateral wall and lead to EP reduction and hearing loss.
connexin 30 controls astroglial polarity during development
In Cx30 and Cx26 (zeige GJB2 Antikörper) knock-out animals, inner hair cells remained stuck at a prehearing stage of development.
Connexin 30, but not connexin 43, hemichannels close upon protein kinase C activation, illustrating that connexin hemichannels display not only isoform-specific permeability profiles but also isoform-specific regulation by protein kinase C.
presence of Cx30 in the cochlea does not compensate for Cx26 (zeige GJB2 Antikörper) loss, and the absence of both connexins from vestibular sensory epithelia is no more injurious than the absence of one of them
four unique Cx30 mutants might cause disease through different mechanisms that also likely include their selective trans-dominant effects on coexpressed connexins.
The cortex modafinil injection increases the expression of mRNA and protein of connexin 30.
Our data reveal that Cx43 (zeige GJA1 Antikörper) promotes the survival of newborn neurons in the adult mouse hippocampus whereas Cx30 restricts their survival.
The observations demonstrate a role for Cx30 and intercellular communication in regulating repair responses in an epithelial tissue.
results showed the A88V and G11R mutants of GJB6 may activate the downstream execution factor, caspase-3 (zeige CASP3 Antikörper), through the extrinsic apoptotic pathway mediated by caspase-8 (zeige CASP8 Antikörper) and the intrinsic apoptotic pathway mediated by caspase-9 (zeige CASP9 Antikörper); study provides further clarification on mechanisms underlying the effect of mutant variants A88V and G11R of the GJB6 gene on the induction of HaCaT cell apoptosis
Investigation of stemness-related CD133 and cMyc (zeige MYC Antikörper) in human samples and rat xenografts exhibited a reciprocal relationship between Cx30 and IGF-1R (zeige IGF1R Antikörper) in the low and high grades (HG) of glioma. Cx30 was completely abolished in HG; levels of IGF-1R (zeige IGF1R Antikörper), CD133 and cMyc (zeige MYC Antikörper) expression were positively correlated with HG. Cx30 transfection could attenuate the malignant burden of glioma in rat xenografts.
Genotype may affect deafness severity, but environmental and other genetic factors may also modulate the severity and evolution of GJB2-GJB6 deafness.
data reveals that a recurrent mutation p.A88V in GJB6 played a pathogenic role in a large Chinese family and emphasizes the importance of gene test in this congenital disorder
Cx26 (zeige GJB2 Antikörper) and Cx30 proteins thus seem not to be co-expressed but to form closely associated assemblies of gap junction plaques.
del(GJB6-D13S1854) was highly prevalent in this sample of deaf Syrian families.
identification and functional characterization of a new Cx30 mutation in a family with hearing impairment in association with previously unreported skin anomalies
Screening of GJB6 gene large deletions among Syrians with congenital hearing impairment.
Periostin (zeige POSTN Antikörper) is a robust marker of glioma malignancy and potential tumor recurrence. Abrogation of glioma stem cell tumorigenicity after periostin (zeige POSTN Antikörper) inhibition provides support for exploring the therapeutic impact of targeting periostin (zeige POSTN Antikörper).
results suggest that SNPs present in the GJB2 (zeige GJB2 Antikörper) and GJB6 genes may have an influence on ARNSHL in humans.
Gap junctions allow the transport of ions and metabolites between the cytoplasm of adjacent cells. They are formed by two hemichannels, made up of six connexin proteins assembled in groups. Each connexin protein has four transmembrane segments, two extracellular loops, a cytoplasmic loop formed between the two inner transmembrane segments, and the N- and C-terminus both being in the cytoplasm. The specificity of the gap junction is determined by which connexin proteins comprise the hemichannel. In the past, connexin protein names were based on their molecular weight, however the new nomenclature uses sequential numbers based on which form (alpha or beta) of the gap junction is present. This gene encodes one of the connexin proteins. Mutations in this gene have been found in some forms of deafness and in some families with hidrotic ectodermal dysplasia.
, connexin 26
, gap junction beta-2 protein
, gap junction protein, beta 6, 30kDa
, gap junction beta-6 protein
, gap junction membrane channel protein beta 6
, gap junction protein, beta 6 (connexin 30)
, ectodermal dysplasia 2, hidrotic (Clouston syndrome)
, connexin 31