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Dog (Canine) Polyclonal GABRB2 Primary Antibody für WB - ABIN550210
McKernan, Rosahl, Reynolds, Sur, Wafford, Atack, Farrar, Myers, Cook, Ferris, Garrett, Bristow, Marshall, Macaulay, Brown, Howell, Moore, Carling, Street, Castro, Ragan, Dawson, Whiting: Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype. in Nature neuroscience 2000
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Mouse (Murine) Polyclonal GABRB2 Primary Antibody für WB - ABIN152539
Borghese, Werner, Topf, Baron, Henderson, Boehm, Blednov, Saad, Dai, Pearce, Harris, Homanics, Harrison: An isoflurane- and alcohol-insensitive mutant GABA(A) receptor alpha(1) subunit with near-normal apparent affinity for GABA: characterization in heterologous systems and production of knockin mice. in The Journal of pharmacology and experimental therapeutics 2006
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Rat (Rattus) Polyclonal GABRB2 Primary Antibody für ICC, IHC - ABIN1742467
Kerti-Szigeti, Nusser: Similar GABAA receptor subunit composition in somatic and axon initial segment synapses of hippocampal pyramidal cells. in eLife 2016
Rat (Rattus) Polyclonal GABRB2 Primary Antibody für WB - ABIN361447
Antflick, Hampson: Modulation of glutamate release from parallel fibers by mGlu4 and pre-synaptic GABA(A) receptors. in Journal of neurochemistry 2012
Cow (Bovine) Polyclonal GABRB2 Primary Antibody für ELISA - ABIN451807
Lo, Lau, Xuan, Chan, Feng, He, Cao, Liu, Luan, Xue: Association of SNPs and haplotypes in GABAA receptor beta2 gene with schizophrenia. in Molecular psychiatry 2004
In the hippocampus of developing piglet brain the alpha-1 and beta-2 subunits were shown to immunolabel various cells and processes in the dentate gyrus (DG), CA1 and CA3.
Results provide plausible epigenetic evidence of the GABAA receptor beta2 subunit involvement in the schizophrenia-like behaviors and demonstrate the potential use of zebrafish models in neuropsychiatric research.
GABRB2 polymorphisms might not be associated with schizophrenia.
Study finds that optimal processing of aversive prediction errors is reduced in individuals genetically predisposed (polymorphisms in GABRB2 and ErbB4) towards decreased GABA neurotransmission.
high-resolution cryo-electron microscopy structures of the human alpha1beta2gamma2 GABAA receptor, the predominant isoform in the adult brain, in complex with GABA and the benzodiazepine site antagonist flumazenil, the first-line clinical treatment for benzodiazepine overdose
we report the discovery of a de novo heterozygous missense mutation in the GABRB2 gene that encodes the b2 subunit of the GABAA receptor. Our in vitro studies indicate that this mutation causes Early myoclonic encephalopathy via disruption of GABAergic inhibition in the brain
The GABRB2 downregulation significantly inhibited the colony formation, migration, and invasion of the three PTC cell lines and GABRB2 plays important tumorigenic functions and acts as a novel oncogene in papillary thyroid carcinoma.
These results reveal alterations in GABRB2 genotype-dependent methylation and hydroxymethylation in schizophrenia.
Data show evidence for the schizophrenia candidate gene gamma-aminobutyric acid A receptor beta 2 (GABRB2) to play a role in heroin dependence.
Our findings underscore the need for further investigation into the mechanisms by which mutations in GABRB2 contribute to neurological and developmental dysfunction.
Deletion of the N-terminal extension and putative alpha-helix in heteromeric alpha1beta2gamma2 GABAA receptors in the beta2 subunit affected GABA sensitivity and desensitization.
Both mRNA and protein of GABAB receptor subunits, GABAB1 and GABAB2, were co-expressed in cultured human RPE cells; GABAB receptors regulate the [Ca2+]i via a pertussis toxin-sensitive Gi/o-protein pathway and a phospholipase C pathway
This study demonstrates altered patterns of N-glycosylation of GABRB2 in the temporal lobe in schizophrenia.
high expression of GABBR2 with a low expression of GABR(A3) may predict a better outcome in non-small cell lung cancer
These findings revealed that GABRB2 is associated with psychosis, the core symptom and an endophenotype of schizophrenia.
Report additive inhibition of human alpha1beta2gamma2 GABAA receptors by mixtures of commonly used drugs of abuse.
Presented is a full-length alpha(1)beta(2)gamma(2) GABA(A) receptor model optimized for agonists and benzodiazepine allosteric modulators.
Mutation of GABA receptor beta2 subunit tyrosine residues in the binding pocket shifts the GABA concentration-response curve; GABA binding rates are reduced by mutation to binding pocket tyrosines.
GABRA receptor beta2 subunit is not involved in amygdala hyperexcitability of patients with temporal lobe epilepsy.
This study demonistrated that GABRB2 expression was under epigenetic regulation that varied with development, genotype and disease status, and these regulatory mechanisms were observably disrupted in SCZ and BPD.
Drugs of abuse directly modulate activity of human alpha(1)beta(2)gamma(2) GABA(A) receptor.
mRNA expression of Gaba(A)beta2 receptor subunit, which preferentially assembles with alpha1 receptor subunits, is also 20% lower in layers 3 and 4 of the dorsolateral prefrontal cortex.
These extensive schizophrenia-like and comorbid phenotypes brought about by Gabrb2 knockout, in conjunction with our previous findings on GABRB2 association with schizophrenia, support a pivotal role of GABRB2 in schizophrenia etiology.
Rebound potentiation is an input-specific plasticity that occurs only at basket cell-Purkinje cell inhibitory synapses and critically relies on GABAA receptors containing the beta2-subunit.
Gabrb2 receptor subunits are expressed in interneurons of the dentate gyrus along with alpha1 and delta subunits.
The gamma2 subunits (of GABA A receptors) interacted with Beta2 subunit N-glycans and subdomains containing the glycosylation sites.
In an epileptic stargazer mouse model, Gabrb2 receptor subunit expression in the ventral thalamus is increased.
These studies identify a novel gephyrin-binding motif in GABA(A) R beta2 and beta3 large cytoplasmic loops.
Data indicate that the expression levels of [beta]2/3 GABAAR showed 2.81 +/- 0.08-fold and 3.83 +/- 0.07-fold increases, respectively, in the pancreatectomized mice 3 and 14 days after surgery.
Differential cell surface expression of GABAA receptor alpha1, alpha6, beta2 and beta3 subunits in cultured mouse cerebellar granule cells influence of cAMP-activated signalling.
deletion of beta2 subunit of GABAA receptors reduces actions of alcohol and other drugs
GABA(A) receptors interact directly with ethylmaleimide sensitive factor, a critical regulator of vesicular dependent protein trafficking.
a conserved lysine in the TM2-3 of alpha1, beta2, and gamma2 of the GABA-A receptor has an asymmetric function in different GABAA subunits
Results describe an up-regulation in the tyrosine kinase phosphorylation of GABA(A )receptor beta(2)- and gamma(2)-subunits following chronic ethanol exposure, but no effect on alpha(1)-subunit in mouse cultured cortical neurons.
Deletion of the beta(2) subunit had no effect on the diazepam-induced current and therefore these extrasynaptic receptors do not contain this subunit.
Different NMDA-receptor subunit 1 and GABA(B)-receptor subunit 2 levels observed in naive mouse strains reflect strain-dependent expression of subunits and are proposed to lead to altered stoichiometry of GABA(B)-receptor complexes.
The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 2 subunit. It is mapped to chromosome 5q34 in a cluster comprised of genes encoding alpha 1 and gamma 2 subunits of the GABA A receptor. Alternative splicing of this gene generates 2 transcript variants, differing by a 114 bp insertion.
gamma-aminobutyric acid (GABA) A receptor, beta 2
, GABA A receptor beta 2 subunit
, gamma-aminobutyric acid receptor subunit beta-2
, gamma-aminobutyric acid receptor subunit beta-2-like
, GABA(A) receptor subunit beta-2
, Gamma-aminobutyric acid receptor beta 2
, gamma-aminobutyric acid (GABA-A) receptor, subunit beta 2
, gamma-aminobutyric acid receptor, subunit beta 2
, GABAA receptor betaZ2
, gamma-aminobutyric acid A receptor, beta 2
, GABA-A receptor, beta-2 subunit
, gamma-aminobutyric acidA receptor beta 2 subunit
, GABA(A) receptor, beta 2
, gamma-aminobutyric acid A receptor beta 2
, gamma-aminobutyric acid A receptor, subunit beta 2
, gamma-aminobutyric acid receptor beta-2 subunit