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Findings suggest that Flg mutation causes the decrease in sweating in the murine model.
Loss of epidermal AP1 (zeige JUN Proteine) reduces filaggrin level, alters chemokine (zeige CCL1 Proteine) expression and produces an ichthyosis (zeige LBR Proteine)-related phenotype.
increased activity of the PI3K/AKT (zeige AKT1 Proteine) signaling pathway in Pelo (zeige PELO Proteine)-deficient skin might conflict with the dephosphorylation of profilaggrin and thereby affect its proper processing into filaggrin monomers and ultimately the epidermal differentiation
Filaggrin deficiency did not affect the epidermal tight junction barrier directly, but once dermatitis occurred, the skin inflammation induced TJ dysfunction
Filaggrin deficiency promotes the dissemination of cutaneously inoculated vaccinia virus.
Hypoxic treatment of primary keratinocytes induced filaggrin (Flg) gene expression in a HIF1alpha (zeige HIF1A Proteine)- and HIF2alpha (zeige EPAS1 Proteine)-dependent manner.
the a/a ma ft/ma ft/J mouse model can be used as an appropriate model to study early AD onset associated with profilaggrin deficiency.
Mere impairment of filaggrin degradation by loss of caspase 14 (zeige CASP14 Proteine) does not influence the inflammatory threshold of atopic dermatitis.
Complete filaggrin deficiency led to altered barrier integrity and enhanced sensitization, which are important factors in early-phase atopic dermatitis.
The decreased expression of epidermal growth factor receptor (EGFR (zeige EGFR Proteine)), E-cadherin (zeige CDH1 Proteine), occludin (zeige OCLN Proteine), and SIRT1 (zeige SIRT1 Proteine) in the skin of Flg(ft) mice, compared with those in C57BL/6J mice, is reported.
The results show that patients carrying filaggrin mutations had increase prevalence of Staphylococcus aureus colonization.
We suggest that SNP in FLG (zeige FGFR1 Proteine) (rs11204981) may serve as an important predictive marker for the combined eczema plus asthma phenotype, and that the highest level of expression in heterozygous may have a protective role in developing allergy phenotype.
This study indicates an increased susceptibility to actinic keratosis in individuals with homozygous, but not heterozygous, FLG (zeige FGFR1 Proteine) mutations and in patients with atopic dermatitis compared to psoriasis.
This study demonstrated, for the first time, that FLG (zeige FGFR1 Proteine) expression in UCB is associated with eczema development in infancy. Moreover, our analysis provided prediction models that were capable of discriminating, to a great extent, between those who will and will not develop eczema in infancy.
In a side-to-side comparison of two different methods to determine NMF in atopic dermatitis patients: Raman microspectroscopy and stratum corneum tape stripping followed by HPLC. both methods demonstrated a concentration-depth dependence of NMF and reduced NMF levels in the carriers of filaggrin null mutations
FLG (zeige FGFR1 Proteine) and POSTN (zeige POSTN Proteine) expression may be downregulated and upregulated, respectively, in the esophageal mucosa of patients with active eosinophilic esophagitis, and these changes may be restored with treatment in a significant percentage of cases.
immunoreactivity for filaggrin was significantly more intense in the oral mucosa in the patients with OLP/OLL compared with healthy controls
atopic dermatitis patients without palmoplantar hyperlinearity unlikely to carry FLG (zeige FGFR1 Proteine) mutations
FLG (zeige FGFR1 Proteine) mutations are strongly associated with atopic eczema and confer a significant risk of allergic sensitization and asthma in the context of eczema in Polish children.
There was no association of the atopy risk variants in the FLG (zeige FGFR1 Proteine) gene with OFG.
The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.
, keratin intermediate filament-associated protein
, epidermal filaggrin
, Filaggrin (profilaggrin)