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E-cadherin silencing relies on the formation of a complex between the paRNA and microRNA-guided Argonaute 1 (zeige EIF2C1 Proteine) that, together, recruit SUV39H1 (zeige SUV39H1 Proteine) and induce repressive chromatin modifications in the gene promoter
The results show how E-cadherin instructs the assembly of the LGN/NuMA complex at cell-cell contacts, and define a mechanism that couples cell division orientation to intercellular adhesion.
Low CDH1 expression is associated with pancreatic cancer.
the dysregulation of TET2/E-cadherin/beta-catenin (zeige CTNNB1 Proteine) regulatory loop is a critical oncogenic event in HCC (zeige FAM126A Proteine) progression
At the molecular level, transcription of the adherens junction protein E (zeige CRISP1 Proteine)-cadherin is upregulated on nicotinic acid addition, leading to accumulation of E-cadherin protein at the cell-cell boundary. This can be attributed to nicotinic acid's ability to facilitate the ubiquitination and degradation of Snail1 (zeige SNAI1 Proteine), a transcription factor that represses E-cadherin expression.
down-regulation of USP48 (zeige USP48 Proteine) increases E-cadherin expression and epithelial barrier integrity through reducing TRAF2 (zeige TRAF2 Proteine) stability
AnxA5 (zeige ANXA5 Proteine) 2D-network mediates E-cadherin mobility in the plasmalemma that triggers human trophoblasts aggregation and thereby cell fusion.
The disassociation of the beta-catenin (zeige CTNNB1 Proteine)/E-cadherin complex in the osteoblast membrane under stretch loading and the subsequent translocation of beta-catenin (zeige CTNNB1 Proteine) into the nucleus may be an intrinsic mechanical signal transduction mechanism.
The presence of E-cadherin decreases cortical contractility during mitosis through a signaling cascade leading to multipolar divisions, and its knockout promotes clustering and survival of cells with multiple centrosomes.
E-cadherin expression is not significantly linked to metastatic disease in pancreatic ductal adenocarcinoma.
These results provide the first in vivo evidence that Flotillins regulate E-cadherin-mediated cell-cell junctions to allow epiboly progression.
These collective findings indicate that loss of Bit1 (zeige PTRH2 Proteine) expression contributes to the acquisition of malignant phenotype of human lung epithelial cells via Erk (zeige MAPK1 Proteine) activation-induced suppression of E-cadherin expression.
In zebrafish, E-cadherin is expressed in lens epithelium, whereas N-cadherin (zeige CDH2 Proteine) is required for lens fiber growth
These data indicate that emi1 (zeige FBXO5 Proteine) deficiency-induced defects in vivo are due to the dysregulation of an APC/C-Cdh1 molecular axis.
without Chp (zeige CHP Proteine) signaling, E-cadh shifts to intracellular vesicles rather than the adhesive contacts needed for directed cell movement during epiboly
Downregulation of E-cadherin gene may cause omphalocele in the Cd chick model by disrupting CRT (zeige CALR Proteine)-mediated Ca(2 (zeige CA2 Proteine)+) signaling and AJs.
analyzed expression patterns of three zebrafish classical (type I) cadherins (cadherin-1, -2, and -4) in the embryonic zebrafish cranial ganglia and lateral line system
cadherin-1 is detected in the epidermis of the embryonic limb buds and the larval pectoral fins of zebrafish
hab/E-cadherin is necessary for the cell rearrangements that spread the teleost blastoderm over the yolk
Lgl2 (zeige LLGL2 Proteine) and E-cadherin act antagonistically to control the localisation of integrin alpha 6 (zeige ITGA6 Proteine) during the formation of hemidesmosomes in the developing epidermis
E-cadherin/beta-catenin (zeige CTNNB1 Proteine) complex plays an important role in mediating the morphological remodeling of porcine trophoblast cells during placental development.
E-cadherin mRNA/protein were up-regulated in all flutamide-treated corpus luteum of mid- and late pregnancy.
In pig kidney, strong E-cadherin expression was observed in the basolateral plasma membrane of the tubular epithelial cells. E-cadherin immunolabeling was not detected in glomeruli or blood vessels of pig kidney.
Localisation of NANOG (zeige NANOG Proteine), OCT4 (zeige POU5F1 Proteine), and E-CADHERIN in porcine pre- and peri (zeige PLIN1 Proteine)-implantation embryos.
The epiblast expressed epithelial markers, MUC1 (zeige MUC1 Proteine) and E-CADHERIN, and the pluripotency markers, DNMT3B (zeige DNMT3B Proteine) and CRIPTO (zeige TDGF1 Proteine).
JNK deficient embryos also have increased intercellular adhesion and defects in e-cadherin localization. Conversely, embryos with overactive JNK have epidermal fragility, increased E-cadherin internalization, and increased membrane localized clathrin.
the switch from E- to N-cadherin (zeige CDH2 Proteine) during epithelial-mesenchymal transition is essential for acquisition of Contact inhibition of locomotion behavior.
Data identify an E-cadherin-dependent mechanical circuit that integrates adhesion, contractile forces and biochemical signaling to drive the polarized organization of junctional tension necessary to build an in vivo epithelial barrier.
E-cadherin expression is reduced in prenatal pancreatic islets of Bmpr1a-deleted mice.
Real-time PCR showed E-cad mRNA decreased in SCC25 while increased in RAW 264.7 of the indirect cell co-culture model, and immunofluoresence (IF) observed the evident switch of E-cad staining from SCC25 to RAW 264.7
Study found that E-cad is crucial for proper morphogenesis and cell movements during gastrulation indicating that a tight spatio-temporal control of cadherin expression is mandatory for morphogenesis independent of their function in tissue sorting.
NAC1 downregulates the E-cadherin repressor ZEB1 directly via transcriptional repression.
Stretch induced p120 (zeige CTNND1 Proteine) degradation and the endocytosis of E-cadherin, which induced beta-catenin (zeige CTNNB1 Proteine) translocation into the nucleus, a key event in lung injury progress and repair.
IGF-II-mediated loss of E-cadherin is central in developing hepatomegaly in mice and abnormal cell growth in the hepatoma cell line
Overall, hypoxia-induced activation of Twist/miR (zeige MLXIP Proteine)-214/E-cadherin axis is involved in the EMT (zeige ITK Proteine) of TECs, and anti-miR (zeige MLXIP Proteine)-214 may be an attractive strategy to ameliorate the progression of renal fibrosis.
Study shows that over time, epithelial tumor cells undergo epithelial state to a mesenchymal-like state changes (including loss of E-cadherin expression) during primary tumor growth and E-cadherin is re-expressed in metastatic tumor cells.
Neutrophil elastase has the capacity to cleave E-cad and interfere with its cell-cell adhesion function in acutely injured lung epithelium.
Transfection of zygotes with 100 and 200 nM E-cadherin siRNA led to a 72 and 38% reduction, respectively, in E-cadherin mRNA relative abundance in Day 7 blastocysts compared with controls.
E-cadherin and beta-catenin (zeige CTNNB1 Proteine) were distributed not only at the cell to cell boundary but throughout the cytoplasm in binucleate trophoblast cells
Results describe the effect of suppression of connexin 43 (zeige GJA1 Proteine) and E-cadherin on the development, mRNA and protein expression of bovine blastocysts cultured in vitro or in vivo.
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites.
, cadherin 1, E-cadherin (epithelial)
, calcium-dependent adhesion protein, epithelial
, cell-CAM 120/80
, epithelial cadherin
, hypothetical protein LOC368517
, cadherin 1, epithelial
, half baked
, cadherin 1, type 1, E-cadherin (epithelial)
, liver cell adhesion molecule
, liver cell adhesion protein
, Epithelial cadherin