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CDH1 promoter methylation may be correlated with cervical cancer carcinogenesis, especially for Caucasians. It was associated with histological subtypes
High UTX (zeige KDM6A Proteine) expression is independently associated with a better prognosis in patients with esophageal squamous cell carcinoma (ESCC) and downregulation of UTX (zeige KDM6A Proteine) increases ESCC cell growth and decreases E-cadherin expression. Our results suggest that UTX (zeige KDM6A Proteine) may be a novel therapeutic target for patients with ESCC.
Data suggest that ECAD, STAT3 (zeige STAT3 Proteine), Bak (zeige BAK1 Proteine), and Bcl-xL (zeige BCL2L1 Proteine) are expressed in affected endometrial tissues of women with endometrioid adenocarcinoma depending on neoplasm staging and cell differentiation. This study was conducted using immunohistochemistry of surgically resected tissues. (STAT3 (zeige STAT3 Proteine) = signal transducer and activator of transcription 3 (zeige STAT3 Proteine) protein; Bak (zeige BAK1 Proteine) = pro-apoptotic protein BAK (zeige BAK1 Proteine); Bcl-xL (zeige BCL2L1 Proteine) = BCL2 associated agonist of cell death (zeige BAD Proteine))
LncRNA RP11 (zeige PRPF31 Proteine)-789C1.1 inhibited EMT (zeige ITK Proteine) in GC through the RP11 (zeige PRPF31 Proteine)-789C1.1/miR (zeige MLXIP Proteine)-5003/E-cadherin axis, which could be a promising therapeutic target for Gastric Cancer.
Using single-molecule localization microscopy, we show that pAJs in these cells reach more than 1 mum in length and consist of several cadherin clusters with crystal-like density interspersed within sparser cadherin regions. Notably, extrajunctional cadherin appears to be monomeric, and its density is almost four orders of magnitude less than observed in the pAJ regions.
CDH1 methylation may play a role in the initiation and progression of salivary carcinoma ex pleomorphic adenoma
We illustrate the approach using immunohistochemical measurements of the epithelial-mesenchymal transition marker E-cadherin in a set of colorectal primary tumors from a population-based prospective cohort in North Carolina
The aim of our study was to analyze the immunohistochemical expression of beta-catenin (zeige CTNNB1 Proteine), E-cadherin and Snail (zeige SNAI1 Proteine), depending on clinico-morphological aspects of the laryngeal squamous cell carcinomas. Results revealed variable E-cadherin, beta-catenin (zeige CTNNB1 Proteine) and Snail (zeige SNAI1 Proteine) expression, depending on differentiation degree and tumor stage.
Twist, E-cadherin, and N-cadherin (zeige CDH2 Proteine) protein were differently expressed in endometrioid adenocarcinoma tissues and in normal endometrium which indicates their potential function for endometrioid adenocarcinoma development.
Findings uncover a new regulatory network in RCC (zeige XRCC1 Proteine) involving metastasis-promoting miR (zeige MLXIP Proteine)-720 that directly targets expression of key metastasis-suppressing proteins E-cadherin and alphaE-catenin (zeige CTNNA1 Proteine) complex.
These results provide the first in vivo evidence that Flotillins regulate E-cadherin-mediated cell-cell junctions to allow epiboly progression.
These collective findings indicate that loss of Bit1 (zeige PTRH2 Proteine) expression contributes to the acquisition of malignant phenotype of human lung epithelial cells via Erk (zeige MAPK1 Proteine) activation-induced suppression of E-cadherin expression.
In zebrafish, E-cadherin is expressed in lens epithelium, whereas N-cadherin (zeige CDH2 Proteine) is required for lens fiber growth
These data indicate that emi1 (zeige FBXO5 Proteine) deficiency-induced defects in vivo are due to the dysregulation of an APC/C-Cdh1 molecular axis.
without Chp (zeige CHP Proteine) signaling, E-cadh shifts to intracellular vesicles rather than the adhesive contacts needed for directed cell movement during epiboly
Downregulation of E-cadherin gene may cause omphalocele in the Cd chick model by disrupting CRT (zeige CALR Proteine)-mediated Ca(2 (zeige CA2 Proteine)+) signaling and AJs.
analyzed expression patterns of three zebrafish classical (type I) cadherins (cadherin-1, -2, and -4) in the embryonic zebrafish cranial ganglia and lateral line system
cadherin-1 is detected in the epidermis of the embryonic limb buds and the larval pectoral fins of zebrafish
hab/E-cadherin is necessary for the cell rearrangements that spread the teleost blastoderm over the yolk
Lgl2 (zeige LLGL2 Proteine) and E-cadherin act antagonistically to control the localisation of integrin alpha 6 (zeige ITGA6 Proteine) during the formation of hemidesmosomes in the developing epidermis
E-cadherin/beta-catenin (zeige CTNNB1 Proteine) complex plays an important role in mediating the morphological remodeling of porcine trophoblast cells during placental development.
E-cadherin mRNA/protein were up-regulated in all flutamide-treated corpus luteum of mid- and late pregnancy.
In pig kidney, strong E-cadherin expression was observed in the basolateral plasma membrane of the tubular epithelial cells. E-cadherin immunolabeling was not detected in glomeruli or blood vessels of pig kidney.
Localisation of NANOG (zeige NANOG Proteine), OCT4 (zeige POU5F1 Proteine), and E-CADHERIN in porcine pre- and peri (zeige PLIN1 Proteine)-implantation embryos.
The epiblast expressed epithelial markers, MUC1 (zeige MUC1 Proteine) and E-CADHERIN, and the pluripotency markers, DNMT3B (zeige DNMT3B Proteine) and CRIPTO (zeige TDGF1 Proteine).
JNK deficient embryos also have increased intercellular adhesion and defects in e-cadherin localization. Conversely, embryos with overactive JNK have epidermal fragility, increased E-cadherin internalization, and increased membrane localized clathrin.
the switch from E- to N-cadherin (zeige CDH2 Proteine) during epithelial-mesenchymal transition is essential for acquisition of Contact inhibition of locomotion behavior.
E-cadherin expression is reduced in prenatal pancreatic islets of Bmpr1a-deleted mice.
Real-time PCR showed E-cad mRNA decreased in SCC25 while increased in RAW 264.7 of the indirect cell co-culture model, and immunofluoresence (IF) observed the evident switch of E-cad staining from SCC25 to RAW 264.7
Study found that E-cad is crucial for proper morphogenesis and cell movements during gastrulation indicating that a tight spatio-temporal control of cadherin expression is mandatory for morphogenesis independent of their function in tissue sorting.
NAC1 downregulates the E-cadherin repressor ZEB1 directly via transcriptional repression.
Stretch induced p120 (zeige CTNND1 Proteine) degradation and the endocytosis of E-cadherin, which induced beta-catenin (zeige CTNNB1 Proteine) translocation into the nucleus, a key event in lung injury progress and repair.
IGF-II-mediated loss of E-cadherin is central in developing hepatomegaly in mice and abnormal cell growth in the hepatoma cell line
Overall, hypoxia-induced activation of Twist/miR (zeige MLXIP Proteine)-214/E-cadherin axis is involved in the EMT (zeige ITK Proteine) of TECs, and anti-miR (zeige MLXIP Proteine)-214 may be an attractive strategy to ameliorate the progression of renal fibrosis.
Study shows that over time, epithelial tumor cells undergo epithelial state to a mesenchymal-like state changes (including loss of E-cadherin expression) during primary tumor growth and E-cadherin is re-expressed in metastatic tumor cells.
Neutrophil elastase has the capacity to cleave E-cad and interfere with its cell-cell adhesion function in acutely injured lung epithelium.
We describe a mouse model in which inducible deletion of E-cadherin in prostate luminal cells results in their apoptotic cell death by anoikis, in the absence of phenotypic effects in the surrounding stroma
Transfection of zygotes with 100 and 200 nM E-cadherin siRNA led to a 72 and 38% reduction, respectively, in E-cadherin mRNA relative abundance in Day 7 blastocysts compared with controls.
E-cadherin and beta-catenin (zeige CTNNB1 Proteine) were distributed not only at the cell to cell boundary but throughout the cytoplasm in binucleate trophoblast cells
Results describe the effect of suppression of connexin 43 (zeige GJA1 Proteine) and E-cadherin on the development, mRNA and protein expression of bovine blastocysts cultured in vitro or in vivo.
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites.
, cadherin 1, E-cadherin (epithelial)
, calcium-dependent adhesion protein, epithelial
, cell-CAM 120/80
, epithelial cadherin
, hypothetical protein LOC368517
, cadherin 1, epithelial
, half baked
, cadherin 1, type 1, E-cadherin (epithelial)
, liver cell adhesion molecule
, liver cell adhesion protein
, Epithelial cadherin