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ADH1B (zeige ADH1B Proteine) and CDH1 polymorphisms predict prognosis in male patients with non-metastatic laryngeal cancer
We identified the known APC (zeige APC Proteine)/C regulator Cdh1 and the F-box protein Fbxl15 (zeige FBXL15 Proteine) as specific modulators of N-cyclin B1 (zeige CCNB1 Proteine)-luciferase steady-state levels and turnover. Collectively, our studies suggest that analyzing the steady-state levels of luciferase fusion proteins in parallel facilitates identification of specific regulators of protein turnover.
Low CDH1 expression is associated with lung metastasis in melanoma.
select gene expression alterations in c.1380delA CDH1 SB.mhdgc-1 cells, are reported.
Analysis highlights significant association between CHD1 rs9929218 polymorphism and CRC (zeige CALR Proteine) susceptibility.
Reduced expression of E-cadherin in clear cell renal carcinoma
The data suggest that reduced expression of E-cadherin and over-expression of Slug, Snail (zeige SNAI1 Proteine), and TGF-beta (zeige TGFB1 Proteine) induce epithelial to mesenchymal transition in ameloblastoma.
CDH4 (zeige CDH4 Proteine) may play a negative role in the growth and metastasis of salivary adenoid cystic carcinoma via co-expression with E-cadherin.
Reduced E-cadherin expression is commonly reported in esophageal adenocarcinoma and independently predicts neoplasm metastasis and poor patient survival.
PI3Kbeta associated with N-cadherin and PIK3CB depletion selectively disrupted N-cadherin cell adhesions in PTEN-mutant bladder carcinoma.
These results provide the first in vivo evidence that Flotillins regulate E-cadherin-mediated cell-cell junctions to allow epiboly progression.
These collective findings indicate that loss of Bit1 (zeige PTRH2 Proteine) expression contributes to the acquisition of malignant phenotype of human lung epithelial cells via Erk (zeige MAPK1 Proteine) activation-induced suppression of E-cadherin expression.
In zebrafish, E-cadherin is expressed in lens epithelium, whereas N-cadherin (zeige CDH2 Proteine) is required for lens fiber growth
These data indicate that emi1 (zeige FBXO5 Proteine) deficiency-induced defects in vivo are due to the dysregulation of an APC/C-Cdh1 molecular axis.
without Chp (zeige CHP Proteine) signaling, E-cadh shifts to intracellular vesicles rather than the adhesive contacts needed for directed cell movement during epiboly
Downregulation of E-cadherin gene may cause omphalocele in the Cd chick model by disrupting CRT (zeige CALR Proteine)-mediated Ca(2 (zeige CA2 Proteine)+) signaling and AJs.
analyzed expression patterns of three zebrafish classical (type I) cadherins (cadherin-1, -2, and -4) in the embryonic zebrafish cranial ganglia and lateral line system
cadherin-1 is detected in the epidermis of the embryonic limb buds and the larval pectoral fins of zebrafish
hab/E-cadherin is necessary for the cell rearrangements that spread the teleost blastoderm over the yolk
Lgl2 (zeige LLGL2 Proteine) and E-cadherin act antagonistically to control the localisation of integrin alpha 6 (zeige ITGA6 Proteine) during the formation of hemidesmosomes in the developing epidermis
E-cadherin mRNA/protein were up-regulated in all flutamide-treated corpus luteum of mid- and late pregnancy.
In pig kidney, strong E-cadherin expression was observed in the basolateral plasma membrane of the tubular epithelial cells. E-cadherin immunolabeling was not detected in glomeruli or blood vessels of pig kidney.
Localisation of NANOG (zeige NANOG Proteine), OCT4 (zeige POU5F1 Proteine), and E-CADHERIN in porcine pre- and peri (zeige PLIN1 Proteine)-implantation embryos.
The epiblast expressed epithelial markers, MUC1 (zeige MUC1 Proteine) and E-CADHERIN, and the pluripotency markers, DNMT3B (zeige DNMT3B Proteine) and CRIPTO (zeige TDGF1 Proteine).
JNK deficient embryos also have increased intercellular adhesion and defects in e-cadherin localization. Conversely, embryos with overactive JNK have epidermal fragility, increased E-cadherin internalization, and increased membrane localized clathrin.
the switch from E- to N-cadherin (zeige CDH2 Proteine) during epithelial-mesenchymal transition is essential for acquisition of Contact inhibition of locomotion behavior.
in the Alzheimer's disease (AD)mouse model APP (zeige APP Proteine)/PS1 (zeige PSEN1 Proteine), lower cdh1 levels were observed in pyramidal neurons in CA1 (zeige CA1 Proteine) when compared to age-matched wildtype mice. In this review, we provide a complete list of APC (zeige APC Proteine)/C substrates that are involved in the nervous system and we discuss their functions. We also summarize recent studies that show neurobiological effects in cdh1 knockout mouse models.
Stretch induced p120 (zeige CTNND1 Proteine) degradation and the endocytosis of E-cadherin, which induced beta-catenin (zeige CTNNB1 Proteine) translocation into the nucleus, a key event in lung injury progress and repair.
IGF-II-mediated loss of E-cadherin is central in developing hepatomegaly in mice and abnormal cell growth in the hepatoma cell line
Overall, hypoxia-induced activation of Twist/miR (zeige MLXIP Proteine)-214/E-cadherin axis is involved in the EMT (zeige ITK Proteine) of TECs, and anti-miR (zeige MLXIP Proteine)-214 may be an attractive strategy to ameliorate the progression of renal fibrosis.
Study shows that over time, epithelial tumor cells undergo epithelial state to a mesenchymal-like state changes (including loss of E-cadherin expression) during primary tumor growth and E-cadherin is re-expressed in metastatic tumor cells.
This study reveals a novel role for Cdh1 in craniofacial development through promoting APC (zeige APC Proteine)-dependent non-proteolytic ubiquitination and activation of Gsc (zeige GSC Proteine).
Neutrophil elastase has the capacity to cleave E-cad and interfere with its cell-cell adhesion function in acutely injured lung epithelium.
We describe a mouse model in which inducible deletion of E-cadherin in prostate luminal cells results in their apoptotic cell death by anoikis, in the absence of phenotypic effects in the surrounding stroma
Our results provide a mechanistic explanation for the spontaneous emergence of pluripotent cells from GSC (zeige GSC Proteine) cultures; namely, rare GSCs upregulate CDH1 and initiate MET, processes normally kept in check by ZEB1 and TGF-beta (zeige TGFB1 Proteine) signaling, thereby ensuring germ cells are protected from aberrant acquisition of pluripotency.
PTEN loss in E-cadherin-deficient mouse mammary epithelial cells rescues apoptosis and results in development of classical invasive lobular carcinoma.
Transfection of zygotes with 100 and 200 nM E-cadherin siRNA led to a 72 and 38% reduction, respectively, in E-cadherin mRNA relative abundance in Day 7 blastocysts compared with controls.
E-cadherin and beta-catenin (zeige CTNNB1 Proteine) were distributed not only at the cell to cell boundary but throughout the cytoplasm in binucleate trophoblast cells
Results describe the effect of suppression of connexin 43 (zeige GJA1 Proteine) and E-cadherin on the development, mRNA and protein expression of bovine blastocysts cultured in vitro or in vivo.
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites.
, cadherin 1, E-cadherin (epithelial)
, calcium-dependent adhesion protein, epithelial
, cell-CAM 120/80
, epithelial cadherin
, cadherin 1, epithelial
, half baked
, cadherin 1, type 1, E-cadherin (epithelial)
, liver cell adhesion molecule
, liver cell adhesion protein
, Epithelial cadherin