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anti-Human COL2A1 Antikörper:
anti-Mouse (Murine) COL2A1 Antikörper:
anti-Rat (Rattus) COL2A1 Antikörper:
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Human Polyclonal COL2A1 Primary Antibody für WB - ABIN3042879
Zhang, Ding, Shi, Li, Haom, Ke, Tang: Effects of exogenous urotensin II on vascular remodelling after balloon injury. in Clinical and experimental pharmacology & physiology 2010
Show all 17 Pubmed References
Mouse (Murine) Polyclonal COL2A1 Primary Antibody für IHC (fro), WB - ABIN5518709
Fu, Liu, Yang, Wang, Yuan, Lin, Jiang: Interleukin-18-induced inflammatory responses in synoviocytes and chondrocytes from osteoarthritic patients. in International journal of molecular medicine 2012
Show all 17 Pubmed References
Cow (Bovine) Monoclonal COL2A1 Primary Antibody für IHC (fro), IHC (p) - ABIN567566
Burgeson, Hollister: Collagen heterogeneity in human cartilage: identification of several new collagen chains. in Biochemical and biophysical research communications 1979
Show all 7 Pubmed References
Human Monoclonal COL2A1 Primary Antibody für ELISA, WB - ABIN560425
Jin, Moreira Teixeira, Krouwels, Dijkstra, van Blitterswijk, Karperien, Feijen: Synthesis and characterization of hyaluronic acid-poly(ethylene glycol) hydrogels via Michael addition: An injectable biomaterial for cartilage repair. in Acta biomaterialia 2010
Show all 5 Pubmed References
Cow (Bovine) Polyclonal COL2A1 Primary Antibody für IF, IHC (p) - ABIN541824
Wang, Yang, Lin, Liu, Liu, Lin: Cartilage regeneration in SCID mice using a highly organized three-dimensional alginate scaffold. in Biomaterials 2011
Show all 2 Pubmed References
Human Polyclonal COL2A1 Primary Antibody für IF (cc) - ABIN2559415
Shi, Ma, Zhang, Li, Jiang, Qin: Hypoxia combined with spheroid culture improves cartilage specific function in chondrocytes. in Integrative biology : quantitative biosciences from nano to macro 2015
Chicken Polyclonal COL2A1 Primary Antibody für IF, IHC (p) - ABIN4369774
Landman, Miclea, van Blitterswijk, Karperien: Small molecule inhibitors of WNT/?-catenin signaling block IL-1?- and TNF?-induced cartilage degradation. in Arthritis research & therapy 2014
the novel mutation of COMP (zeige COMP Antikörper) may result in intracellular accumulation of the mutant protein. Decreased plasma COMP (zeige COMP Antikörper) and increased plasma CTX (zeige CYP27A1 Antikörper)-II may potentially serve as diagnostic markers of PSACH (zeige COMP Antikörper) but may not be applicable in the presymptomatic carrier.
In summary, regarding the association between Type II Collagen Degradation Marker (CTx (zeige CYP27A1 Antikörper)-II) and VDR (zeige CYP27B1 Antikörper) polymorphisms in patients with osteochondrosis, this study observed the presence of higher CTx (zeige CYP27A1 Antikörper)-II circulating levels in patients with bb, Aa ,and TT genotypes, and F and T alleles, in comparison with the healthy controls.
A c.G1636A (p.G546S) mutation in the COL2A1 in 3 members of a family was associated with different metaphyseal changes. Findings revealed a different causative amino acid substitution (glycine to serine) associated with the "dappling" and "corner fracture" metaphyseal abnormalities and may provide a useful reference for evaluating the phenotypic spectrum and variability of type II collagenopathies.
By acting probably as a posttranscriptional regulator with a different efficacy on COL2A1 and COL1A2 (zeige COL1A2 Antikörper) expression, miR (zeige MLXIP Antikörper)-29b can contribute to the collagens imbalance associated with an abnormal chondrocyte phenotype.
Strong correlations between the expression of type I, II, IV collagen and osteopontin (zeige SPP1 Antikörper) and the clinical stage of tympanosclerosis indicate the involvement of these proteins in excessive fibrosis and pathological remodeling of the tympanic membrane.
In this study, three novel and two known mutations in the COL2A1 gene were identified in six of 16 Chinese patients with Stickler syndrome. This is the first study in a cohort of Chinese patients with Stickler syndrome, and the results expand the mutation spectrum of the COL2A1 gene.
We identified three novel heterozygous COL2A1 mutations (Gly537Asp, Gly909Ser, and Gly1149Val) in three unrelated Chinese Spondyloepiphyseal dysplasia congenita families.
We report a novel nonsense mutation in exon 2 of COL2A1 that displays incomplete penetrance and/or variable age of onset with extraocular manifestations.
Report examines how a COL2A1 intron 2 de novo variant and polymorphism affect exon 2 inclusion in the COL2A1 transcript, and identifies potential transacting splicing factors that interact with these different pre-mRNA sequences. Also, using a cohort of patients with rhegmatogenous retinal detachment and controls, a significant difference was found in the frequency of the COL2A1 variant rs1635532 between the two groups.
Spondylometaphyseal dysplasia (SMD) corner fracture type is a heterogeneous disorder with a subset of patients showing overlap with type II collagenopathies. Thus, COL2A1 molecular testing should be considered in patients with the finding of corner fracture-like lesions in the settings of SMD.
In contrast to previous studies using C2C the present study demonstrated that synovial levels of Coll2 (zeige SEMA3D Antikörper)-1 were significantly elevated in tarsocrural joints affected with osteochondrosis
These results suggested that serum and synovial fluid (SF) collagen type II (CTX (zeige VSIG1 Antikörper)-II) concentrations and SF:serum CTX (zeige VSIG1 Antikörper)-II ratio may be used to detect cartilage degradation in horses with joint injury.
These results suggest that PEP-1-SIRT2 (zeige SIRT2 Antikörper) promotes matrix metalloproteinases-induced dedifferentiation via ERK (zeige MAPK1 Antikörper) signaling in articular chondrocytes.
Collagen type II serum levels, along with COMP (zeige COMP Antikörper) levels, were effective for early osteoarthritis diagnosis in an animal model.
The expression of II type collagen and MMP-7 (zeige MMP7 Antikörper) is correlated to a retrogression of acetabular cartilage and increases obviously in early developmental dysplasia. [MMP7 (zeige MMP7 Antikörper)]
found bone destruction and bone loss phenotype in vertebral bone in beta-catenin (zeige CTNNB1 Antikörper)(Col2CreER) KO mice
Kartogenin effectively increased the expression of Col (zeige HDAC1 Antikörper) II and aggrecan (zeige ACAN Antikörper) in hNPCs and slowed the degeneration of intervertebral discs stimulated by IL-1b (zeige IL1B Antikörper) and TNF-a (zeige TNF Antikörper)
These findings suggest a novel mechanism of action of SOX5 (zeige SOX5 Antikörper)/6; namely, the SOX9 (zeige SOX9 Antikörper)/5/6 combination enhances Col2a1 transcription through a novel enhancer in intron 6 together with the enhancer in intron 1.
this study shows role of Del-1 in the regulation of platelet-monocyte interplay and the subsequent heterotypic aggregate formation in the blood-mediated inflammatory reaction in islet transplantation
Alpha-tectorin (zeige TECTA Antikörper) and beta-tectorin (zeige TECTB Antikörper) crosslink type II collagen fibrils and connect the tectorial membrane to the spiral limbus.
Col2 expression was seen in the prehypertrophic zone of the mandibular condyle cartilage.
Rspo2 (zeige RSPO2 Antikörper) activates Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signaling to reduce Col2a1 and Sox9 (zeige SOX9 Antikörper) and to facilitate differentiation of proliferating chondrocytes into hypertrophic chondrocytes in growth cartilage
The MC13 mutation in Col2a1 causes an incompletely penetrant splicing defect.
The mutant G1170S Col2a1 gene in mice clearly alters the transgenic murine phenotype and cartilage matrix homeostasis.
Data indicate that tamoxifen decreased collage type II COL2A1 by activating matrix metallopeptidases MMP-2 (zeige MMP2 Antikörper)/13 expression.
Analysis of tissue maturation markers showed an increase in COLL II and a decrease in SOX9 (zeige SOX9 Antikörper) expression in the swine tibial menisci with age.
Data suggest that focal adhesion kinase (FAK)-SMAD 2/3 mediate signal crosstalk between type II collagen and TGF-beta1 and regulate glycosaminoglycan secretion in chondrocytic cells.
spontaneous missense mutation within COL2A1 in chondrodysplasia (zeige COL11A1 Antikörper)
a first example of a dominant COL2A1 splice site variant as candidate causal mutation of a severe lethal chondrodysplasia (zeige COL11A1 Antikörper) phenotype
Denaturation of the chimeric collagen increased its affinity for fibronectin (zeige FN1 Antikörper), as seen for mammalian collagens.
Data show that expression of mRNAs for aggrecan (zeige ACAN Antikörper), collagen type II, and versican (zeige Vcan Antikörper) were significantly effected by the intervention.
Data show that biglycan (zeige BGN Antikörper), collagen type I, collagen type II, decorin (zeige DCN Antikörper), and versican (zeige Vcan Antikörper) were significantly affected by vibration duration, frequency, and amplitude.
specific ADAMTS-2 (zeige Adamts2 Antikörper) domains cleave the aminopropeptide of fibrillar procollagens types I-III and V
Changes in aggrecan (zeige ACAN Antikörper) and type II collagen promoter activity in transfected chondrocyte-laden cylindrical constructs were evaluated in response to a range of loading frequencies and durations.
SMase down-regulates type II collagen in articular chondrocytes via activation of the ERK signaling cascade, redistribution of SOX9, and recruitment of c-Fos
Response of the chondrocyte to a cryptic sequence of denaturated type II collagen may play a role in naturally occurring hypertrophy in endochondral ossification and in the development of cartilage pathology in osteoarthritis.
IGF-I (zeige IGF1 Antikörper) dose-dependently maintained cartilage formation
A small highly conserved sequence (R2) located 1.7 kb upstream of the presumptive transcriptional initiation siteof Col2a1a gene, was identified.
Data show that both col1a1a and col2a1b were found in actinotrichia forming cells.
This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for this gene.
alpha-1 type II collagen
, cartilage collagen
, collagen II, alpha-1 polypeptide
, collagen alpha-1(II) chain
, collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital)
, type II collagen
, collagen type IIA
, pro alpha1 type II collagen
, disproportionate micromelia
, procollagen, type II, alpha 1
, Procollagen II alpha 1
, collagen type II (Col2A1) gene, enhancer region
, alpha 1 type II procollagen
, alpha 1 type IIA collagen
, procollagen alpha 1(II)
, type II collagen alpha1
, alpha-1 type II' collagen
, cyanogen bromide
, pro-alpha 1(II)
, collagen, type II, alpha 1
, collagen alpha-1(II) chain-like
, collagen type II
, collagen type II, alpha 1