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Human VEGFR2 Protein expressed in Insect Cells - ABIN809790
Hiley, Chard, Gangeswaran, Tysome, Briat, Lemoine, Wang: Vascular endothelial growth factor A promotes vaccinia virus entry into host cells via activation of the Akt pathway. in Journal of virology 2013
These results indicate that VEGF-C (zeige VEGFC Proteine)-induced MSC (zeige MSC Proteine) osteogenesis is mediated through VEGFR2 and VEGFR3 (zeige FLT4 Proteine), and followed the activation of the ERK (zeige MAPK1 Proteine)/RUNX2 (zeige RUNX2 Proteine) signaling pathway.
Endoglin (zeige ENG Proteine) prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 signalling
CLEC14A (zeige CLEC14A Proteine) acts in vascular homeostasis by fine-tuning VEGFR-2 and VEGFR-3 (zeige FLT4 Proteine) signaling in endothelial cells
The elevated soluble VEGFR-2 that was found in the aortas of apoE (zeige APOE Proteine)(-/-) mice with atherosclerosis binds to and diminishes the activity of VEGF-C (zeige VEGFC Proteine).
Data show that Leishmania major infection initiates enhanced vascular endothelial growth factor-A (zeige VEGFA Proteine)/VEGFR-2 signaling and suggest that VEGFR-2-dependent lymphangiogenesis is a mechanism that restricts tissue inflammation in leishmaniasis.
VEGFR3 (zeige FLT4 Proteine) limits VEGFR2 expression and VEGF (zeige VEGFA Proteine)/VEGFR2 pathway activity in quiescent and angiogenic blood vascular endothelial cells, thereby preventing excessive vascular permeability.
fetal mouse lung mesenchymal cells express Vegfr2 and respond to VEGF-A (zeige VEGFA Proteine) stimulation.
Deletion of microRNA miR (zeige MLXIP Proteine)-150 increased the retinal pathological angiogenesis in high-fat-diet (HFD) induced type 2 diabetic mice, which was in part through vascular endothelial growth factor receptor 2 (VEGFR2).
findings demonstrated that a multi-component Chinese medicine DHI effectively increased blood flow recovery after tissue ischemia in diabetic mice by promoting angiogenesis and improving glucose tolerance through a concomitant activation of VEGF-A (zeige VEGFA Proteine)/VEGFR-2 and PPARdelta (zeige PPARD Proteine) signaling pathways
Intronic Flk1 genetic enhancer element directs arterial-specific expression via RBPJ (zeige RBPJ Proteine)-mediated venous repression.
Endothelial SCUBE2 may be a novel coreceptor for VEGFR2 and potentiate VEGF-induced signaling in adult angiogenesis.
The study aimed to assess the usefulness of the determination of cytokines: IL-8 (zeige IL8 Proteine), VEGF (zeige VEGFA Proteine) and its soluble receptors: VEGF (zeige VEGFA Proteine)-R1, VEGF (zeige VEGFA Proteine)-R2 in patients with endometrial cancer. The concentrations of IL-8 (zeige IL8 Proteine) were an independent prognostic factor in the assessment of overall survival in patients with type I endometrial cancer, while the concentrations of VEGFR2 in those with type II.
High VEGFR expression is associated with melanoma.
OGN (zeige OGN Proteine) plays a critical role in negatively regulating ischaemia-induced angiogenesis by inhibiting VEGF (zeige VEGFA Proteine)-VEGFR2 signalling and thereby attenuating endothelial cells tube formation, proliferation, and migration.
Cryptotanshinone potently inhibits VEGF-induced angiogenesis by suppressing VEGFR2 activation and its downstream Src/FAK and ERK1/2 signaling pathways in HUVECs.
The model showed agreement at several key nodes, involving scaffolding proteins Gab1, Gab2 (zeige GAB2 Proteine) and their complexes with Shp2 (zeige PTPN11 Proteine). VEGFR2 recruitment of Gab1 is greater in magnitude, slower, and more sustained than that of Gab2 (zeige GAB2 Proteine). As Gab2 (zeige GAB2 Proteine) binds VEGFR2 complexes more transiently than Gab1, VEGFR2 complexes can recycle and continue to participate in other signaling pathways.
TRIM28 (zeige TRIM28 Proteine) acts as a central factor in controlling endothelial inflammatory responses and angiogenic activities by retaining expression of TNFR-1 (zeige TNFRSF1A Proteine) and -2 and VEGF receptor 2 in endothelial cells
The results suggest that Necl-4 (zeige CADM4 Proteine) enhances VEGF (zeige VEGFA Proteine)-induced activation of PLCgamma-c-Raf (zeige RAF1 Proteine)-MEK (zeige MAP2K1 Proteine)-ERK (zeige EPHB2 Proteine) pathway without affecting the phosphorylation and internalization of VEGFR2.
circRNA-MYLK (zeige MYLK Proteine) might function as competing endogenous RNA for miR (zeige MLXIP Proteine)-29a, which could contribute to empithelial-mesenchymal transformation and the development of bladder cancer by activating VEGFA (zeige VEGFA Proteine)/VEGFR2 and downstream Ras/ERK (zeige EPHB2 Proteine) signaling pathway.
VEGFR2 is consistently expressed in small artery myocytes of older people and may mediate effects of VEGF on brain vascular aging.
Chromatin-modifying agents converted hADFCs to OCT4+ and VEGFR-2+ capillary tube-forming cells in a 2D matrix in VEGF-dependent manner
Here we demonstrate that VEGF (zeige VEGFA Proteine)-165 mediates MSC (zeige MSC Proteine) differentiation into ECs via VEGFR-2-dependent induction of Sox18 (zeige SOX18 Proteine), which ultimately coordinates the transcriptional upregulation of specific markers of the EC phenotype
NOS stimulation via PI3K, calpain proteases, and SIRT1 (zeige SIRT1 Proteine)-dependent deacetylation downstream from VEGFR2 activation contributes to these vasodilator responses.
we analyzed the expression and cellular distribution of Flt-1(VEGFR-1 (zeige FLT1 Proteine)) and Flk-1 (KDR/VEGFR-2)in newborn piglet brain
expression of FLK1, CD146 (zeige MCAM Proteine) and microvessel density of angiogenesis at the first week of reperfused acute myocardial infarction.
VEGF (zeige VEGFA Proteine) supplementation at the late embryonic developmental stage might improve the developmental potential of both IVF (zeige SCN5A Proteine) and somatic nuclear transfer preimplantation porcine embryos through its receptors.
The VEGFR2 mRNA was only upregulated in early glomerulogenesis, suggesting that VEGFR2 is important for the vascular growth.
increased placental expression of the VEGF receptor (zeige FLT1 Proteine) system is associated with increased placental vascular density observed with the advancement of gestation in the pig
VEGF ligand-receptor system may play an important role in the development and maintenance of the corpus luteum in pigs.
VEGF (zeige VEGFA Proteine)/Flk-1/Flt-1 (zeige FLT1 Proteine) system is activated during myocardial ischemia reperfusion injury.
Hemodialysis graft placement leads to early increases in wall shear stress, VEGF-A (zeige VEGFA Proteine), pro-MMP-9 (zeige MMP9 Proteine), MMP-2 (zeige MMP2 Proteine), VEGFR-1 (zeige FLT1 Proteine), VEGFR-2, and TIMP-1 (zeige TIMP1 Proteine), which may contribute to the development of venous stenosis.
data for the first time demonstrate a calpain/PTP1B/VEGFR2 negative feedback loop in the regulation of VEGF-induced angiogenesis. Modulation of local PTP1B and/or calpain activities may prove beneficial in the treatment of impaired wound healing in diabetes.
endothelial cells exposed to TGF-beta1 (zeige TGFB1 Proteine) lose both tip and stalk cell identity, possibly mediated by loss of VEGFR2 signaling.
These results suggest that non-dominant follicles maintain a greater concentration of the mRNA expression of both membrane and soluble VEGF receptors; but follicular dominance is related to a reduction in the mRNA expression of sVEGFR1 and sVEGFR2.
Data suggest that galectin-1 (zeige LGALS1 Proteine) and VEGFR-2 are expressed at mid-luteal stages in luteal cells of corpus luteum; galectin-1 (zeige LGALS1 Proteine) binds directly to asparagine-linked glycans (N-glycans) on VEGFR-2 in luteal cells.
MMP-1 (zeige MMP1 Proteine) promotes VEGFR2 expression and proliferation of endothelial cells through stimulation of PAR-1 (zeige F2R Proteine) and activation of NF-kappaB (zeige NFKB1 Proteine)
Vascular endothelial growth factor receptor-2 activates ADP-ribosylation factor 1 (zeige ARF1 Proteine) to promote endothelial nitric-oxide synthase (zeige NOS3 Proteine) activation and nitric oxide release from endothelial cells
VEGFR2 mRNA expression was higher at the mid and late luteal stages than at the early I and early II luteal stages, and VEGFR2 protein was higher at the mid and late luteal stages than at estrus (P<0.05)
Alterations in the expression of VEGF-A (zeige VEGFA Proteine) and bFGF (zeige FGF2 Proteine) systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.
involved in sphingosine 1-phosphate-stimulated phosphorylation of Akt (zeige AKT1 Proteine) and endothelial nitric-oxide synthase (eNOS (zeige NOS3 Proteine))
Placenta growth factor (zeige PGF Proteine) expression is regulated by both VEGF (zeige VEGFA Proteine) and hyperglycaemia via VEGFR-2.
Antenatal intratracheal VEGF (zeige VEGFA Proteine) administration was associated with an increase in Flk-1 immunoreactivity.
Ca(2 (zeige CA2 Proteine)+) oscillations depended upon VEGF receptor-2 (Vegfr2) and Vegfr3 (zeige FLT4 Proteine) in endothelial cells budding from the dorsal aorta (DA) and posterior cardinal (zeige CARD8 Proteine) vein, respectively.
Methylglyoxal acts on smaller blood vessels in zebrafish via the VEGF receptor (zeige FLT1 Proteine) signaling cascade, thereby describing a new mechanism that can explain vascular complications under hyperglycemia and elevated MG concentrations.
methylation of Lys (zeige LYZ Proteine)(1041) promotes the activation of VEGFR-2 and that similar posttranslational modification could also regulate the activity of other receptor tyrosine kinases.
Perturbation of the HSP70 (zeige HSPA1A Proteine)-HSP90 (zeige HSP90 Proteine) heat-shock protein axis stimulates degradation of endothelial VEGFR2.
Data indicate that the increase in FLT1/sFLT1 (zeige FLT1 Proteine) protein levels upon miR-10 (zeige LILRB2 Proteine) knockdown inhibited the angiogenic behavior of endothelial cells largely by antagonizing vascular endothelial growth factor receptor 2 signaling: [miR10 (zeige LILRB2 Proteine)]
Early Flk1 expression may be induced by cooperative interactions between Gata (zeige GATA4 Proteine), Tcf (zeige HNF4A Proteine)/Lef, Cdx (zeige CDX1 Proteine) and ER71/Etv2 (zeige ETV2 Proteine) under the control of Bmp, Wnt (zeige WNT2 Proteine) and Fgf signaling.
Using 2 distinct pharmacologic VEGFR2 inhibitors the study shows that rap1b (zeige RAP1A Proteine) and VEGFR2 act additively to control angiogenesis in vivo.
Data show that flk1 is not required for proper vasculogenesis and hematopoiesis in zebrafish embryos; however, the disruption of flk1 impairs the formation or function of vessels generated by sprouting angiogenesis
flk1 is a direct target of FoxH1 (zeige FOXH1 Proteine); FoxH1 (zeige FOXH1 Proteine) is involved in vessel formation in zebrafish.
Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas.
vascular endothelial growth factor receptor 2
, VEGF receptor-2
, fetal liver kinase 1
, kinase NYK
, protein-tyrosine kinase receptor flk-1
, soluble vascular endothelial growth factor receptor 2
, vascular endothelial growth factor receptor- 2
, vascular endothelial growth factor receptor-2
, vascular endothelial growth factor receptor-3
, FLK1 kinase insert domain receptor (VEGF receptor 2)
, FLK1 kinase insert domain receptor (a type III receptor tyrosine kinase) (VEGF receptor 2)
, kinase insert domain protein receptor
, fetal liver kinase-1
, protein-tyrosine kinase receptor Flk-1
, soluble VEGFR2
, tyrosine kinase growth factor receptor
, flk-1 type VEGF receptor
, flk-1 receptor
, protein-tyrosine kinase
, tyrosine kinase receptor
, VEGF receptor-2/Flk-1
, VEGFR-2 homolog B
, fetal liver kinase 1b
, kinase insert domain receptor (a type III receptor tyrosine kinase), b
, kinase insert domain receptor-B
, protein-tyrosine kinase receptor flk-1b
, vascular endothelial growth factor receptor 2 homolog B
, kinase insert domain receptor-A
, kinase insert domain receptor-like
, vascular endothelial growth factor receptor 4
, vascular endothelial growth factor receptor kdr-like
, vascular endothelial growth factor receptor type 2