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Human VEGFR2 Protein expressed in Insect Cells - ABIN809790
Hiley, Chard, Gangeswaran, Tysome, Briat, Lemoine, Wang: Vascular endothelial growth factor A promotes vaccinia virus entry into host cells via activation of the Akt pathway. in Journal of virology 2013
These results indicate that VEGF-C (zeige VEGFC Proteine)-induced MSC (zeige MSC Proteine) osteogenesis is mediated through VEGFR2 and VEGFR3 (zeige FLT4 Proteine), and followed the activation of the ERK (zeige MAPK1 Proteine)/RUNX2 (zeige RUNX2 Proteine) signaling pathway.
transgenic mice may serve as valid models for the validation of novel therapies blocking the VEGFR-2 signaling pathway in hemangioma-like lesions and other vascular diseases
found that WT1 (zeige WT1 Proteine) and KDR are co-expressed in Sertoli cells of the testes and somatic cells of embryonic ovaries. Furthermore, WT1 (zeige WT1 Proteine) bound to the Kdr promoter in the chromatin of embryonic testes and ovaries. KDR signaling represses the testis-promoting gene Sox9 (zeige SOX9 Proteine) in embryonic XX gonads
This is the first report demonstrating the spatiotemporal expression patterns of Flk1 and Flt1 (zeige FLT1 Proteine) in the coronary vascular system during development and after MI; thus, this study suggests that these factors have distinct and important functions in coronary angiogenesis.
VEGFR2-associated alpha(2,6)-linked sialic acid plays an important role in modulating VEGF (zeige VEGFA Proteine)/VEGFR2 interaction, EC pro-angiogenic activation and neovessel formation.
These results revealed that vascular sprouting and permeability are both controlled through the VEGFR2-TSAd-c-Src signaling pathway in a subset of tissues, which may be useful in developing strategies to control tissue-specific pathological angiogenesis.
Data show that editing of genomic VEGFR2 locus using rAAV1-mediated CRISPR/Cas9 abrogates angiogenesis in the mouse models of oxygen-induced retinopathy and laser-induced choroid neovascularization.
Our study demonstrates that Prox1 (zeige C16orf35 Proteine)-GFP/Flk1::myr-mCherry mice are a useful model for studying coordinated hemangiogenic and lymphangiogenic responses
Endoglin (zeige ENG Proteine) prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 signalling
CLEC14A (zeige CLEC14A Proteine) acts in vascular homeostasis by fine-tuning VEGFR-2 and VEGFR-3 (zeige FLT4 Proteine) signaling in endothelial cells
The elevated soluble VEGFR-2 that was found in the aortas of apoE (zeige APOE Proteine)(-/-) mice with atherosclerosis binds to and diminishes the activity of VEGF-C (zeige VEGFC Proteine).
Icrucumab and ramucirumab are recombinant human IgG1 monoclonal antibodies that bind vascular endothelial growth factor (VEGF) receptors 1 and 2 (VEGFR-1 and -2), respectively. VEGFR-1 activation on endothelial and tumor cell surfaces increases tumor vascularization and growth and supports tumor growth via multiple mechanisms, including contributions to angiogenesis and direct promotion of cancer cell proliferation.
REVIEW. the interplay among the ETS transcription factor (zeige FEV Proteine) ETV2 (zeige ETV2 Proteine), vascular endothelial growth factor, and its receptor VEGFR2/FLK1 is essential for hematopoietic and vascular development. Emerging studies also support the role of these three factors and possible interplay in hematopoietic and vascular regeneration.
DOT1L (zeige DOT1L Proteine) cooperates with transcription factor ETS (zeige ETV7 Proteine)-1 (zeige ETS1 Proteine) to stimulate the expression of VEGFR2, thereby activating ERK1/2 and AKT (zeige AKT1 Proteine) signaling pathways and promoting angiogenesis.
This study provides new insights into the mechanism of VEGFR2 dimerization and activation.
Cases with high MDSC infiltration, which was inversely correlated with intratumoral CD8(+) T-cell infiltration, exhibited shorter overall survival. In a mouse model, intratumoral MDSCs expressed both VEGFR1 and VEGFR2. VEGF expression in ovarian cancer induced MDSCs, inhibited local immunity, and contributed to poor prognosis
our results illustrated that CDK5 (zeige CDK5 Proteine)-mediated KDR phosphorylation controls prolactin (zeige PRL Proteine) pituitary adenoma progression and KDR pSer-229 serves as a potential prognostic biomarker for both noninvasive and invasive pituitary adenomas.
Data indicate that simultaneous targeting of molecules that control distinct phases of angiogenesis, such as ALK1 (zeige ACVRL1 Proteine) and VEGFR, is a valid strategy for treatment of metastatic renal cell carcinoma (zeige MOK Proteine) (mRCC).
Primary cultures derived from melanomas harboring the KDR variant were more proliferative and invasive than KDR wild type.
this study of cabozantinib (a dual VEGFR2/MET) in metastatic TNBC, while not meeting its prespecified endpoint, showed that treatment is associated with circulating biomarker changes, and is active in a subset of patients.
The efficacy and safety of VEGFR-TKIs after PD-1 (zeige PDCD1 Proteine) inhibition were demonstrated in this retrospective study. The response rate was lower and the median progression-free survival was shorter in those patients who received prior PD-1 (zeige PDCD1 Proteine) in combination with VEGFR-TKI. PD-1 (zeige PDCD1 Proteine) exposure does not seem to significantly influence the safety of subsequent VEGFR-TKI treatment
Here we demonstrate that VEGF (zeige VEGFA Proteine)-165 mediates MSC (zeige MSC Proteine) differentiation into ECs via VEGFR-2-dependent induction of Sox18 (zeige SOX18 Proteine), which ultimately coordinates the transcriptional upregulation of specific markers of the EC phenotype
NOS stimulation via PI3K, calpain proteases, and SIRT1 (zeige SIRT1 Proteine)-dependent deacetylation downstream from VEGFR2 activation contributes to these vasodilator responses.
we analyzed the expression and cellular distribution of Flt-1(VEGFR-1 (zeige FLT1 Proteine)) and Flk-1 (KDR/VEGFR-2)in newborn piglet brain
expression of FLK1, CD146 (zeige MCAM Proteine) and microvessel density of angiogenesis at the first week of reperfused acute myocardial infarction.
VEGF (zeige VEGFA Proteine) supplementation at the late embryonic developmental stage might improve the developmental potential of both IVF (zeige SCN5A Proteine) and somatic nuclear transfer preimplantation porcine embryos through its receptors.
The VEGFR2 mRNA was only upregulated in early glomerulogenesis, suggesting that VEGFR2 is important for the vascular growth.
increased placental expression of the VEGF receptor (zeige FLT1 Proteine) system is associated with increased placental vascular density observed with the advancement of gestation in the pig
VEGF ligand-receptor system may play an important role in the development and maintenance of the corpus luteum in pigs.
VEGF (zeige VEGFA Proteine)/Flk-1/Flt-1 (zeige FLT1 Proteine) system is activated during myocardial ischemia reperfusion injury.
Hemodialysis graft placement leads to early increases in wall shear stress, VEGF-A (zeige VEGFA Proteine), pro-MMP-9 (zeige MMP9 Proteine), MMP-2 (zeige MMP2 Proteine), VEGFR-1 (zeige FLT1 Proteine), VEGFR-2, and TIMP-1 (zeige TIMP1 Proteine), which may contribute to the development of venous stenosis.
data for the first time demonstrate a calpain/PTP1B/VEGFR2 negative feedback loop in the regulation of VEGF-induced angiogenesis. Modulation of local PTP1B and/or calpain activities may prove beneficial in the treatment of impaired wound healing in diabetes.
endothelial cells exposed to TGF-beta1 (zeige TGFB1 Proteine) lose both tip and stalk cell identity, possibly mediated by loss of VEGFR2 signaling.
These results suggest that non-dominant follicles maintain a greater concentration of the mRNA expression of both membrane and soluble VEGF receptors; but follicular dominance is related to a reduction in the mRNA expression of sVEGFR1 and sVEGFR2.
Data suggest that galectin-1 (zeige LGALS1 Proteine) and VEGFR-2 are expressed at mid-luteal stages in luteal cells of corpus luteum; galectin-1 (zeige LGALS1 Proteine) binds directly to asparagine-linked glycans (N-glycans) on VEGFR-2 in luteal cells.
MMP-1 (zeige MMP1 Proteine) promotes VEGFR2 expression and proliferation of endothelial cells through stimulation of PAR-1 (zeige F2R Proteine) and activation of NF-kappaB (zeige NFKB1 Proteine)
Vascular endothelial growth factor receptor-2 activates ADP-ribosylation factor 1 (zeige ARF1 Proteine) to promote endothelial nitric-oxide synthase (zeige NOS3 Proteine) activation and nitric oxide release from endothelial cells
VEGFR2 mRNA expression was higher at the mid and late luteal stages than at the early I and early II luteal stages, and VEGFR2 protein was higher at the mid and late luteal stages than at estrus (P<0.05)
Alterations in the expression of VEGF-A (zeige VEGFA Proteine) and bFGF (zeige FGF2 Proteine) systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.
involved in sphingosine 1-phosphate-stimulated phosphorylation of Akt (zeige AKT1 Proteine) and endothelial nitric-oxide synthase (eNOS (zeige NOS3 Proteine))
Placenta growth factor (zeige PGF Proteine) expression is regulated by both VEGF (zeige VEGFA Proteine) and hyperglycaemia via VEGFR-2.
ghrelin (zeige GHRL Proteine) can inhibit intraplaque angiogenesis and promote plaque stability by down-regulating VEGF (zeige VEGFA Proteine) and VEGFR2 expression, inhibiting the plaque content of macrophages, and reducing MCP-1 (zeige CCL2 Proteine) expression at an advanced stage of atherosclerosis in rabbits
Antenatal intratracheal VEGF (zeige VEGFA Proteine) administration was associated with an increase in Flk-1 immunoreactivity.
Intronic Flk1 genetic enhancer element directs arterial-specific expression via RBPJ (zeige RBPJ Proteine)-mediated venous repression.
Ca(2 (zeige CA2 Proteine)+) oscillations depended upon VEGF receptor-2 (Vegfr2) and Vegfr3 (zeige FLT4 Proteine) in endothelial cells budding from the dorsal aorta (DA) and posterior cardinal (zeige CARD8 Proteine) vein, respectively.
Methylglyoxal acts on smaller blood vessels in zebrafish via the VEGF receptor (zeige FLT1 Proteine) signaling cascade, thereby describing a new mechanism that can explain vascular complications under hyperglycemia and elevated MG concentrations.
methylation of Lys (zeige LYZ Proteine)(1041) promotes the activation of VEGFR-2 and that similar posttranslational modification could also regulate the activity of other receptor tyrosine kinases.
Perturbation of the HSP70 (zeige HSPA1A Proteine)-HSP90 (zeige HSP90 Proteine) heat-shock protein axis stimulates degradation of endothelial VEGFR2.
Data indicate that the increase in FLT1/sFLT1 (zeige FLT1 Proteine) protein levels upon miR-10 (zeige LILRB2 Proteine) knockdown inhibited the angiogenic behavior of endothelial cells largely by antagonizing vascular endothelial growth factor receptor 2 signaling: [miR10 (zeige LILRB2 Proteine)]
Early Flk1 expression may be induced by cooperative interactions between Gata (zeige GATA4 Proteine), Tcf (zeige HNF4A Proteine)/Lef, Cdx (zeige CDX1 Proteine) and ER71/Etv2 (zeige ETV2 Proteine) under the control of Bmp, Wnt (zeige WNT2 Proteine) and Fgf signaling.
Using 2 distinct pharmacologic VEGFR2 inhibitors the study shows that rap1b (zeige RAP1A Proteine) and VEGFR2 act additively to control angiogenesis in vivo.
Data show that flk1 is not required for proper vasculogenesis and hematopoiesis in zebrafish embryos; however, the disruption of flk1 impairs the formation or function of vessels generated by sprouting angiogenesis
flk1 is a direct target of FoxH1 (zeige FOXH1 Proteine); FoxH1 (zeige FOXH1 Proteine) is involved in vessel formation in zebrafish.
Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas.
fetal liver kinase 1
, fetal liver kinase-1
, protein-tyrosine kinase receptor Flk-1
, soluble VEGFR2
, tyrosine kinase growth factor receptor
, vascular endothelial growth factor receptor 2
, VEGF receptor-2
, kinase NYK
, protein-tyrosine kinase receptor flk-1
, soluble vascular endothelial growth factor receptor 2
, vascular endothelial growth factor receptor- 2
, vascular endothelial growth factor receptor-2
, vascular endothelial growth factor receptor-3
, FLK1 kinase insert domain receptor (VEGF receptor 2)
, FLK1 kinase insert domain receptor (a type III receptor tyrosine kinase) (VEGF receptor 2)
, kinase insert domain protein receptor
, flk-1 receptor
, protein-tyrosine kinase
, flk-1 type VEGF receptor
, tyrosine kinase receptor
, VEGF receptor-2/Flk-1
, VEGFR-2 homolog B
, fetal liver kinase 1b
, kinase insert domain receptor (a type III receptor tyrosine kinase), b
, kinase insert domain receptor-B
, protein-tyrosine kinase receptor flk-1b
, vascular endothelial growth factor receptor 2 homolog B