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Study identified the Gas6 (zeige GAS6 Proteine)/TAM (zeige CCNA1 Proteine) receptor pathway with Tyro3 and Mer (zeige MERTK Proteine) as novel targets in colorectal cancer.
These results show that TYRO3, AXL (zeige AXL Proteine) and GAS6 (zeige GAS6 Proteine) are expressed at higher levels in LMS and expression of its ligands correlates to a worse PFS in LMS patients.
Patients with macroalbuminuria diabetes had higher circulating levels of sMer and more urinary soluble Tyro3 and sMer than normoalbuminuric diabetics. Increased clearance of sTyro3 and sMer was associated with loss of tubular Tyro3 and Mer (zeige MERTK Proteine) expression in diabetic nephropathy tissue. During in vitro diabetes, human kidney cells had down-regulation of Tyro3 and Mer (zeige MERTK Proteine) mRNA and increased shedding of sTyro3 and sMer.
TYRO3 is overexpressed in the early stage of colon cancer development and aberrant expression of TYRO3 promotes tumorigenesis and induces EMT (zeige ITK Proteine) through the regulation of SNAI1 (zeige SNAI1 Proteine).
In this paper, we review the biology of the Gas6 (zeige GAS6 Proteine)/Tyro3, Axl (zeige AXL Proteine), and MerTK (zeige MERTK Proteine)(collectively named TAM (zeige CCNA1 Proteine) system)and the current evidence supporting its potential role in the pathogenesis of multiple sclerosis .
these data suggest that Tyro3 contributes significantly to tumor growth, aggressiveness and liver dysfunction
Tyro3 gene dosage modulates Mertk (zeige MERTK Proteine)-associated retinal degeneration, provide strong evidence for a direct role for TYRO3 in RPE (zeige RPE Proteine) phagocytosis, and suggest that an eQTL (zeige EQTN Proteine) can modify a recessive Inherited photoreceptor degenerations.
The mRNA expression levels of Tyro-3, Axl (zeige AXL Proteine) were decreased in pSS (zeige CDSN Proteine) patients. When considering the plasma level, increased levels of soluble Mer (zeige MERTK Proteine) was observed with statistically significant difference.
genetic ablation of a receptor tyrosine kinase (zeige RET Proteine) encoded byTyro3in mice or the functional neutralization of its ortholog in human dendritic cells resulted in enhanced type 2 immunity.
the results of the present study demonstrated that the acquired taxol resistance of ovarian cancer cells was associated with ROS (zeige ROS1 Proteine)-dependent upregulation in the expression of Tyro3 RTK and the subsequent activation of Akt (zeige AKT1 Proteine).
The findings of this study indicated the critical importance of Tyro3 in potentiating central nervous system myelination
This study mapped the autophosphorylation sites of murine Tyro3 to tyrosine 723 and 756, with K540 being required for its kinase activity.
Axl (zeige AXL Proteine), Mertk (zeige MERTK Proteine) and Tyro3 receptors are not required for Zika virus entry and infection.
genetic ablation of a receptor tyrosine kinase (zeige ERBB3 Proteine) encoded byTyro3in mice or the functional neutralization of its ortholog in human dendritic cells resulted in enhanced type 2 immunity.
These results suggest that TAM (zeige CCNA1 Proteine) receptors support NSCs survival, proliferation and differentiation by regulating expression of neurotrophins, especially the nerve growth factor.
Optimal TAM (zeige CCNA1 Proteine) signaling requires coincident TAM (zeige CCNA1 Proteine) ligand engagement of both its receptor and the phospholipid phosphatidylserine regulating TAM (zeige CCNA1 Proteine) receptor tyrosine kinases Tyro3, Axl (zeige AXL Proteine), and Mer (zeige ERH Proteine) and their ligands Gas6 (zeige GAS6 Proteine) and Protein S.
These findings indicate that Tyro3 is a critical signal for synovial hyperplasia, osteoclast differentiation and bone erosion during arthritis.
Axl (zeige AXL Proteine) and Mer (zeige ERH Proteine) (TAM (zeige CCNA1 Proteine)) receptor tyrosine kinases (RTKs) developed persistent inflammatory liver damage resembling AIH. Tyro3(-/-)Axl (zeige AXL Proteine)(-/-)Mer (zeige ERH Proteine)(-/-) triple mutant (TAM (zeige CCNA1 Proteine)(-/-)) mice exhibited chronic hepatitis
Adult brain neurogenesis is reduced in the hippocampus of the Tyro3-/-Axl (zeige AXL Proteine)-/-Mertk (zeige MERTK Proteine)-/- triple-knockout but not in single Tyro3-/- knockouts.
The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and phagocytosis. The encoded protein has also been identified as a cell entry factor for Ebola and Marburg viruses.
TYRO3 protein tyrosine kinase
, Tyrosine-protein kinase receptor TYRO3
, tyrosine-protein kinase receptor TYRO3
, developmental receptor tyrosine kinase
, tyrosine-protein kinase DTK
, tyrosine-protein kinase receptor TYRO3-like
, tyrosine-protein kinase RSE
, tyrosine-protein kinase SKY
, tyrosine-protein kinase TIF
, tyrosine-protein kinase byk
, Bruton agammaglobulinemia tyrosine kinase
, TYRO3 protein tyrosine kinase 3
, Axl-related receptor tyrosine kinase
, protein-tyrosine kinase
, retina-expressed kinase
, Xenopus kinase of Sky family
, tyrosine kinase