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anti-Human TSC2 Antikörper:
anti-Mouse (Murine) TSC2 Antikörper:
anti-Rat (Rattus) TSC2 Antikörper:
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Human Polyclonal TSC2 Primary Antibody für DB, IF - ABIN1881949
Li, Inoki, Guan: Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity. in Molecular and cellular biology 2004
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Rat (Rattus) Polyclonal TSC2 Primary Antibody für DB - ABIN1881935
Larson, Liu, Stevens, Li, Li, Evers, Gao: Tuberous sclerosis complex 2 (TSC2) regulates cell migration and polarity through activation of CDC42 and RAC1. in The Journal of biological chemistry 2010
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Human Polyclonal TSC2 Primary Antibody für DB - ABIN1881947
Dántola, Denofrio, Zurbano, Gimenez, Ogilby, Lorente, Thomas: Mechanism of photooxidation of folic acid sensitized by unconjugated pterins. in Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2010
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Human Polyclonal TSC2 Primary Antibody für DB - ABIN1881948
Liu, Wu, Chen, Ter-Minassian, Asomaning, Zhai, Wang, Su, Heist, Kulke, Lin, Liu, Christiani: A Large-scale genetic association study of esophageal adenocarcinoma risk. in Carcinogenesis 2010
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Human Polyclonal TSC2 Primary Antibody für IF (p), IHC (p) - ABIN701200
Wang, Chen, Deng, Bian, Huang, Lei, Lv, Liu, Li: Repression of TSC1/TSC2 mediated by MeCP2 regulates human embryo lung fibroblast cell differentiation and proliferation. in International journal of biological macromolecules 2017
Human Polyclonal TSC2 Primary Antibody für DB - ABIN6241057
Wu, Storey: Regulation of the mTOR signaling network in hibernating thirteen-lined ground squirrels. in The Journal of experimental biology 2012
The gene expression profiles of WT and tsc2(+/-) larvae revealed 117 differentially expressed genes (DEGs), while between WT and tsc2(-/-) larvae and tsc2(+/-) and tsc2(-/-) larvae there were 1414 and 1079 DEGs, respectively. Pathway enrichment analysis from the WT and tsc2(-/-) DEGs, identified 14 enriched pathways from the up-regulated genes and 6 enriched pathways from the down-regulated genes.
This is the first report using an animal model to show interactions between tsc2, mTORC1 and p53 (zeige TP53 Antikörper) during tumorigenesis.
These results demonstrate a highly conserved role of tsc2 in zebrafish and establish a new animal model for studies of Tuberous sclerosis complex.
Findings indicate six novel mutations: four in the tuberous sclerosis 2 protein (TSC2) gene, of which one is nonsense, two frame shift and one large deletion of 16 exons; and two in the tuberous sclerosis 1 protein (TSC1 (zeige TSC1 Antikörper)) gene, one nonsense and other frame shift.
Tuberous sclerosis complex Chinese Han patients with TSC2 mutations had a higher frequency of mental retardation and there were no significant differences of seizures and skin lesions with TSC1 (zeige TSC1 Antikörper) mutations.
our study demonstrated high rate of TSC1 (zeige TSC1 Antikörper)/2 mutations among clinically diagnosed Russian TS patients. A significant share of these mutations was represented by large gene rearrangements.
Rapamycin-independent IGF2 expression in Tsc2-null mouse embryo fibroblasts and human lymphangioleiomyomatosis cells.
This study demonstrated that the TSC2 mutation related the cerebellar abnormalities in tuberous sclerosis complex.
a novel TSC2 mutation is a cause of mild tuberous sclerosis in a family and has reduced expression
Data found that TSC2 negatively regulates the expression of EP3 (zeige PTGER3 Antikörper) in an mTORC1- independent manner.
All tuberous sclerosis patients were found to have mutations, which included 1 case with tuberous sclerosis 1 protein (TSC1 (zeige TSC1 Antikörper)) mutation and 9 cases with tuberous sclerosis 2 protein (TSC2) mutations (missense mutations in 6, nonsense mutations in 2, and frameshifting mutation in 1 case).
Results support important contributions of TSC2 heterozygous and homozygous mutant cells to the pathogenesis of TSC (zeige SLC12A3 Antikörper) and the important role of p53 (zeige TP53 Antikörper) during reprogramming.
Mutations in TSC2 gene on chromosome 9q34 that encode tuberin are associated with fetal Cardiac Rhabdomyoma that can be the initial finding in patients with Tuberous Sclerosis Complex. 5 known "pathogenic" TSC2-causing gene mutations were confirmed, also detected 6 "likely pathogenic" mutations.
TSC (zeige SLC12A3 Antikörper) loss distorts DNA replication programme and sensitises murine embryonic fibroblasts to genotoxic stress.
Lymphangioleiomyomatosis is fatal lung disease associated with germline/somatic inactivating mutations in TSC2 genes. Data suggest lung lymphangioleiomyomatosis lesions and renal angiomyolipomas overexpress uPA (zeige PLAU Antikörper); Tsc2-/- (or Tsc1 (zeige TSC1 Antikörper)-/-) embryonic fibroblasts from knockout mice express higher uPA (zeige PLAU Antikörper) levels than wild-type cells. (uPA (zeige PLAU Antikörper) = urokinase-type plasminogen activator (zeige PLAU Antikörper); Tsc (zeige SLC12A3 Antikörper) = tuberous sclerosis complex protein)
Loss of the tuberous sclerosis complex (TSC (zeige SLC12A3 Antikörper)) tumor suppressors results in activation of mTORC1 and development of the tumor syndrome tuberous sclerosis complex (TSC (zeige SLC12A3 Antikörper)).
Tsc2-mTOR (zeige FRAP1 Antikörper) signaling in mesenchyme is essential for the maintenance of renal structure and for lung alveolarization.
TSC1 (zeige TSC1 Antikörper)/TSC2 complex upregulation of OPN (zeige SPP1 Antikörper) expression is mediated by transcription factor SOX9 (zeige SOX9 Antikörper) in an mTOR (zeige FRAP1 Antikörper)-independent manner. Moreover, ablation of OPN (zeige SPP1 Antikörper) by deficient TSC1 (zeige TSC1 Antikörper)/TSC2 complex contributed to inactivation of AKT (zeige AKT1 Antikörper) in TSC (zeige SLC12A3 Antikörper) cells
Rheb (zeige RHEB Antikörper) and TSC2 have roles in the mechanical activation of mTOR (zeige FRAP1 Antikörper) signaling
this study shows that TSC2 maintains macrophage quiescence and prevents mTORC1-dependent granulomatous disease with clinical implications for sarcoidosis
TSC2 N-terminal lysine acetylation status affects to its stability modulating mTORC1 signaling and autophagy/cell proliferation.
Repression of TSC1/TSC2 mediated by MeCP2 regulates human embryo lung fibroblast cell differentiation and proliferation.
Porcine circovirus type 2 (PCV2) might induce autophagy via the AMPK (zeige PRKAA1 Antikörper)/ERK (zeige MAPK1 Antikörper)/TSC2/mTOR (zeige FRAP1 Antikörper) signaling pathway in the host cells, representing a pivotal mechanism for PCV2 pathogenesis
prostaglandin F2alpha phosphorylates TSC2 and activates mTOR (zeige FRAP1 Antikörper) and ribosomal protein S6 (zeige RPS6 Antikörper) kinase (zeige RPS6KB1 Antikörper) signaling in an AKT (zeige AKT1 Antikörper)-independent manner
Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms.
tuberous sclerosis complex 2 (TSC2)
, tuberous sclerosis 2
, tuberous sclerosis 2 protein
, tuberous sclerosis 2 protein homolog
, renal carcinoma
, tuberous sclerosis 2 homolog protein