anti-Human TSC1 Antikörper für Enzyme Immunoassay

Recommended TSC1 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Tuberous Sclerosis 1 (TSC1) Antikörper
  • LAM
  • TSC
  • hamartin
  • mKIAA0243
  • tsc1
  • wu:fc38b04
  • TSC complex subunit 1
  • tuberous sclerosis 1
  • TSC complex subunit 1b
  • TSC1
  • Tsc1
  • tsc1b
  • tsc1
Epitop
pSer505
49
41
38
38
38
38
19
19
19
19
19
19
19
19
19
19
19
19
19
19
19
19
19
19
19
16
12
12
10
9
7
7
7
7
4
4
4
3
3
3
3
3
2
2
2
1
1
1
1
1
1
1
1
Reaktivität
Human
445
363
168
28
7
6
5
1
1
Wirt
Kaninchen
709
55
19
2
Klonalität
Polyklonal
Konjugat
Dieser TSC1 Antikörper ist unkonjugiert
67
67
67
64
64
64
5
5
5
5
5
3
3
3
3
3
3
2
2
Applikation
Enzyme Immunoassay (EIA)
518
504
162
68
39
34
30
21
17
8
3
2
2
1
Hersteller
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Hersteller Produkt- Nr.
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Bilder

Produktnummer ABIN358402
$ 390.50
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN5555392 EIA IF WB Rabbit IgG Middle Region, both Isoforms Anmelden zum Anzeigen Polyclonal 0
1 ABIN5555391 EIA WB Rabbit IgG C-Term Anmelden zum Anzeigen Polyclonal 0
1 ABIN2734416 EIA WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0

General

Antigen Tuberous Sclerosis 1 (TSC1) Antikörper
Epitop pSer505
(49), (41), (38), (38), (38), (38), (19), (19), (19), (19), (19), (19), (19), (19), (19), (19), (19), (19), (19), (19), (19), (19), (19), (19), (19), (16), (12), (12), (10), (9), (7), (7), (7), (7), (4), (4), (4), (3), (3), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Human
(445), (363), (168), (28), (7), (6), (5), (1), (1)
Wirt Kaninchen
(709), (55), (19), (2)
Klonalität
Polyklonal
Konjugat Dieser TSC1 Antikörper ist unkonjugiert
(67), (67), (67), (64), (64), (64), (5), (5), (5), (5), (5), (3), (3), (3), (3), (3), (3), (2), (2)
Applikation Enzyme Immunoassay (EIA)
(518), (504), (162), (68), (39), (34), (30), (21), (17), (8), (3), (2), (2), (1)
Pubmed 5 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-TSC1 Antikörper

Target Details TSC1 Anwendungsinformationen Handhabung Referenzen für anti-TSC1 Antikörper (ABIN358402) Bilder
Spezifität This antibody detects TSC1 pSer505.
Reinigung Affinity purification in a 2-step procedure with the control and phosphorylated peptides. The phospho-specific antibody is eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S505 of human TSC1.
Isotyp Ig Fraction

Target Details TSC1

Produktdetails anti-TSC1 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-TSC1 Antikörper (ABIN358402) Bilder zurück nach oben
Antigen
Andere Bezeichnung TSC1 / Hamartin (TSC1 Antibody Abstract)
Hintergrund TSC1 is implicated as a tumor suppressor, and may have a function in vesicular transport. Interaction between TSC1 and TSC2 may facilitate vesicular docking. Defects in TSC1 are the cause of tuberous sclerosis complex (TSC). The molecular basis of TSC is a functional impairement of the hamartin-tuberin complex. TSC is an autosomal dominant multi-system disorder that affects especially the brain, kidneys, heart, and skin. Defects in TSC1 may be a cause of focal cortical dysplasia of Taylor balloon cell type (FCDBC). FCDBC is a subtype of cortical displasias linked to chronic intractable epilepsy. Cortical dysplasias display a broad spectrum of structural changes, which appear to result from changes in proliferation, migration, differentiation, and apoptosis of neuronal precursors and neurons during cortical development.Synonyms: KIAA0243, TSC, Tuberous sclerosis 1 protein
Molekulargewicht 129767 Da
Gen-ID 7248, 9606
UniProt Q92574
Pathways RTK Signalweg, AMPK Signaling, Regulation of Cell Size, Tube Formation

Anwendungsinformationen

Produktdetails anti-TSC1 Antikörper Target Details TSC1 Handhabung Referenzen für anti-TSC1 Antikörper (ABIN358402) Bilder zurück nach oben
Applikations-hinweise ELISA: 1/1,000. Dot Blot: 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-TSC1 Antikörper Target Details TSC1 Anwendungsinformationen Referenzen für anti-TSC1 Antikörper (ABIN358402) Bilder zurück nach oben
Format Liquid
Konzentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) Sodium Azide as preservative.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Referenzen für anti-TSC1 Antikörper (ABIN358402)

Produktdetails anti-TSC1 Antikörper Target Details TSC1 Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Wu, Khalil, Keehn, Saeed, Morgan: "Hamartin and tuberin immunohistochemical expression in cutaneous fibroepithelial polyps." in: Journal of cutaneous pathology, Vol. 31, Issue 5, pp. 383-7, 2004

Jó?wiak, Kwiatkowski, Kotulska, Larysz-Brysz, Lewin-Kowalik, Grajkowska, Roszkowski: "Tuberin and hamartin expression is reduced in the majority of subependymal giant cell astrocytomas in tuberous sclerosis complex consistent with a two-hit model of pathogenesis." in: Journal of child neurology, Vol. 19, Issue 2, pp. 102-6, 2004

Murthy, Han, Beauchamp, Smith, Haddad, Ito, Ramesh: "Pam and its ortholog highwire interact with and may negatively regulate the TSC1.TSC2 complex." in: The Journal of biological chemistry, Vol. 279, Issue 2, pp. 1351-8, 2004

Lewis, Thomas, Murphy, Sampson: "Genotype and psychological phenotype in tuberous sclerosis." in: Journal of medical genetics, Vol. 41, Issue 3, pp. 203-7, 2004

Astrinidis, Senapedis, Coleman, Henske: "Cell cycle-regulated phosphorylation of hamartin, the product of the tuberous sclerosis complex 1 gene, by cyclin-dependent kinase 1/cyclin B." in: The Journal of biological chemistry, Vol. 278, Issue 51, pp. 51372-9, 2003

Bilder

Produktdetails anti-TSC1 Antikörper Target Details TSC1 Anwendungsinformationen Handhabung Referenzen für anti-TSC1 Antikörper (ABIN358402) zurück nach oben
Bilder des Herstellers
 image for anti-Tuberous Sclerosis 1 (TSC1) (pSer505) antibody (ABIN358402) anti-Tuberous Sclerosis 1 (TSC1) (pSer505) antibody