Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Weitere Synonyme anzeigen
Wählen Sie die gewünschte Spezies
By immunohistochemistry, the localization of Neurotrophinss has been observed mainly in Purkinje cells; TrkA (zeige NTRK1 Proteine) and TrkB-receptors in cells and fibers of granular and molecular layers. TrkC (zeige NTRK3 Proteine) was faintly detected
BDNF (zeige BDNF Proteine)-TrkB influences the expression level of components of chemokine (zeige CCL1 Proteine) signaling including Cxcr4b, and the generation of progenitors of mechanoreceptors, at the level of expression of Atoh1a-Atp2b1a.
Light regulates the expression of the BDNF (zeige BDNF Proteine)/TrkB2 system in the adult zebrafish retina.
Study showed that complex relationships exist between BDNF (zeige BDNF Proteine)/TrkB gene expression and interneuron marker gene expression that appear to be dependent on the presence of testosterone at adolescence
Study reports that cells residing in the human subependymal zone (SEZ) may maintain their responsiveness to mature BDNF (zeige BDNF Proteine), although this responsiveness seems to undergo age-related alterations. Results indicate that TrkB-TK+ expression may promote neuronal differentiation, whereas TrkB-TK- expression may block neuronal differentiation in favour of neural precursor proliferation and/or glial differentiation.
these findings demonstrate that TrkB-mediated signaling contributes to the induction of malignant phenotypes (proliferation, invasiveness, angiogenesis, lymphangiogenesis, and tumorigenesis) in gallbladder cancer
our findings suggest that heterodimerization of Her2 (zeige ERBB2 Proteine) and TrkB receptors gives breast cancer cells a survival advantage in the brain and that dual inhibition of these receptors may hold therapeutic potential
TrkB-containing exosomes play a key role in the control of glioblastoma progression and aggressiveness, as seen in a model of YKL-40 (zeige CHI3L1 Proteine)-inactivated glioblastoma cells
Female sex and specific allelic variations in the NTRK2 gene were independently associated with mood disorders or depressive disorders in temporal lobe epilepsy patients.
Report an association between antidepressant worsening suicidal ideation and SNP rs1439050 of NTRK2 in depressed subjects treated by tianeptine.
This work demonstrates that DHF, through activation of TrkB signaling pathway, has a preventive function in d-glucose-induced apoptosis in PRE cells in diabetic retinopathy.
The aim of the current review was to provide an overview of the role of BDNF (zeige BDNF Proteine)/TrkB pathways in the pathogenesis of breast cancer and its value as a potential therapeutic target.
Data suggest that high expression of TRKB (not TRKA (zeige NTRK1 Proteine) or TRKC (zeige NTRK3 Proteine)) in lung squamous cell carcinoma is correlated with vascular invasion, lymph node metastasis, advanced stage of tumor, and poor prognosis; overall survival of patients with TRKB-high expression is significantly shorter than those with TRKB-low expression; RNA interference against TRKB or BDNF (zeige BDNF Proteine) (TRKB agonist) inhibits cell proliferation of tumor cell line.
Among the adaptations observed following consumption of drugs of abuse or alcohol abuse, BDNF (zeige BDNF Proteine) levels are widely altered in both brain and periphery. Data suggest that BDNF (zeige BDNF Proteine)/TRKB signaling in neurons in specific areas of brain (hippocampus, nucleus accumbens) is altered in protracted withdrawal from drug/alcohol abuse. [REVIEW]
The changes in the expression patterns of proBDNF, BDNF (zeige BDNF Proteine), and their receptors under the influence of chronic alcohol consumption in the depressive ASC (zeige STS Proteine) strain and nondepressive CBA strain mice are different.
A critical period of susceptibility to cigarette smoke exposure exists in the prenatal and early postnatal period, which results a downregulation in brain-derived neurotrophic factor (zeige BDNF Proteine)/tyrosine kinase receptor B signaling in the hippocampus and enhances depression-like behaviors later in life.
Imipramine protected bupivacaine-induced neurotoxicity in DRG, likely via the co-activation of TrkA (zeige NTRK1 Proteine) and TrkB signaling pathways.
Ventral hippocampal trkB is essential to goal-directed action selection, countering habit-based behavior otherwise facilitated by developmental stress hormone exposure.
BDNF (zeige BDNF Proteine) acts retrogradely on TrkB in climbing fibers , and facilitates elimination of climbing fibers synapses from Purkinje cells somata during the third postnatal week.
The three receptor sets considered (mAChR (zeige CHRM3 Proteine), AR and TrkB receptors) intervene in modulating the conditions of the competition between nerve endings.
Signaling through postsynaptic trkB receptors is considered to be an essential part of a cellular mechanism for maintaining the contacts of some, but not all, synaptic contacts onto motoneurons
findings show that BDNF (zeige BDNF Proteine)-TrkB signaling, rather than Dopamine signaling, in the Ventral Tegmental Area -Nuc (zeige SREBF2 Proteine). Accumbens circuit is crucial for facilitating depressive-like depressive-like outcomes after Chronic Social Defeat Stress and they establish BDNF (zeige BDNF Proteine)-TrkB signaling as a pathologic mechanism during periods of chronic stress.
inhibition of Sig (zeige PICALM Proteine)-1 R prevented cocaine-induced TrkB activation in hippocampal neurons.
After spinal cord injury, astrocyte-specific TrkB knock-out mice showed reduced hyperpathic responses and improved motor coordination.
These observations provided evidence that brain-derived naeurotrophic factor(BDNF (zeige BDNF Proteine)) and its receptor (BDNF (zeige BDNF Proteine) receptor) secreted by bovine sperm was important in regulation of insulin (zeige INS Proteine) and leptin (zeige LEP Proteine).
Expressed in ganglionic neuron-like tumor cells, which may activate an embryonic autocrine pathwy involving bdnf (zeige BDNF Proteine)-Trk-B
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for this gene.
neurotrophin receptor B xTrkB-alpha
, BDNF/NT-3 growth factors receptor
, neurotrophic tyrosine kinase, receptor, type 2
, BDNF/NT-3 growth factors receptor-like
, neurotrophic tyrosine kinase receptor type 2
, trkB tyrosine kinase
, tyrosine kinase receptor
, BDNF-tropomyosine receptor kinase B
, tropomyosin-related kinase B
, tyrosine kinase receptor B
, neural receptor protein-tyrosine kinase (trkB)
, trkB protein