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The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
RYK receptor-like tyrosine kinase
, tyrosine kinase RYK
, ryk receptor-like tyrosine kinase
, receptor-like tyrosine kinase
, tyrosine-protein kinase RYK
, tyrosine kinase-related protein
, tyrosine-protein kinase RYK-like
, JTK5A protein tyrosine kinase
, hydroxyaryl-protein kinase
, growth factor receptor
, kinase VIK
, met-related kinase