Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Weitere Synonyme anzeigen
Wählen Sie die gewünschte Spezies
Human ROR1 Protein expressed in HEK-293 Cells - ABIN2731082
Hojjat-Farsangi, Jeddi-Tehrani, Daneshmanesh, Mozaffari, Moshfegh, Hansson, Razavi, Sharifian, Rabbani, Österborg, Mellstedt, Shokri: Spontaneous Immunity Against the Receptor Tyrosine Kinase ROR1 in Patients with Chronic Lymphocytic Leukemia. in PLoS ONE 2015
this study found that in scid (zeige PRKDC Proteine) hu mice, ROR1 was highly expressed in a proportion of bone marrow, spleen, and blood B cells, which were mostly immature B cells
Results find ROR1 as the direct target of miR30a, and show that ROR1 contributes to mir30amediated suppression of TNBC (triple negative breast cancer) cell invasion and migration.
ROR1 and ROR2 (zeige ROR2 Proteine) play distinct roles in endometrial cancer. ROR1 may promote tumor progression, while ROR2 (zeige ROR2 Proteine) may act as a tumor suppressor in endometrioid endometrial cancer.
ROR1 is a promising immunotherapeutic target in many epithelial tumors; however, high cell surface ROR1 expression in multiple normal tissues raises concerns for on-target off-tumor toxicities. Clinical translation of ROR1-targeted therapies warrants careful monitoring of toxicities to normal organs and may require strategies to ensure patient safety
Report shows that ROR1 is highly expressed in colorectal cancer (CRC (zeige CALR Proteine)) tissues when compared with their adjacent normal tissues. The Kaplan-Meier curve indicated that the CRC (zeige CALR Proteine) patients with higher ROR1 expression had significantly shorter overall survival (OS), and those with lower ROR1 expression had longer OS.
this study reveals that 14-3-3zeta (zeige YWHAZ Proteine) plays a critical role in Wnt5a (zeige WNT5A Proteine)/ROR1 signaling, leading to enhanced CLL migration and proliferation.
these studies indicate HS1 (zeige EEF1A2 Proteine) plays an important role in ROR1-dependent Wnt5a (zeige WNT5A Proteine)-enhanced chemokine (zeige CCL1 Proteine)-directed leukemia-cell migration.
This study demonstrates expression of ROR1 and its putative ligand Wnt5a (zeige WNT5A Proteine) in Ewing sarcomas, and of an active ROR1 protein variant in cell lines. ROR1 silencing impaired cell migration in vitro.
expression of ROR1 may promote leukemia-cell activation and survival and enhance disease progression in patients with chronic lymphocytic leukemia.
the mechanistic regulation and linkage of the ROR1-HER3 (zeige ERBB3 Proteine) and Hippo-YAP (zeige YAP1 Proteine) pathway in a cancer-specific context
Ror1 has a critical role in regulating SC proliferation during skeletal muscle regeneration
Ror1 is crucial for spiral ganglion neurons to innervate auditory hair cells. Impairment of ROR1 function largely affects development of the inner ear and hearing in humans and mice.
Although Ror1-mutant mice show no apparent defects in ureteric bud (UB) formation, Ror1; Ror2 (zeige ROR2 Proteine)-double-mutant mice exhibit either defects in UB outgrowth and branching morphogenesis, associated with the loss of the MM from the UB domain, or ectopic formation of the UB.
Wnt5a (zeige WNT5A Proteine)-Ror1 and Wnt5a (zeige WNT5A Proteine)-Ror2 (zeige ROR2 Proteine) signaling pathways regulated neurogenesis in the developing neocortex.
results identify resistin (zeige RETN Proteine) as a potential inhibitory ligand for the receptor ROR1 and demonstrate, for the first time, that ROR1 plays an important role in adipogenesis and glucose homeostasis in 3T3-L1 cells
These findings suggest that Wnt5a (zeige WNT5A Proteine)-Ror-Dishevelled (zeige DVL2 Proteine) signaling constitutes a core noncanonical Wnt (zeige WNT2 Proteine) pathway that is conserved through evolution and is crucial during embryonic development.
loss of the orphan receptor (zeige NR1D2 Proteine) Ror1 results in a variety of phenotypic defects within the skeletal and urogenital systems
these data suggest that Ror1 and Ror2 (zeige ROR2 Proteine) proteins play a key role in Wnt-5a (zeige WNT5A Proteine)-activated signaling pathways leading to synapse formation in the mammalian CNS
Expression and subcellular localization of Ror tyrosine kinase (zeige TYRO3 Proteine) receptors are developmentally regulated in cultured hippocampal neurons.
The ROR1 protein suppression using antisense oligonucleotides or RNA interference (RNAi), neurons extended shorter and less branched minor processes when compared to those in control cells.
This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms.
neurotrophic tyrosine kinase, receptor-related 1
, tyrosine-protein kinase transmembrane receptor ROR1
, neurotrophic tyrosine kinase, receptor related 1
, tyrosine kinase orphan receptor 1
, receptor tyrosine kinase-like orphan receptor 1
, tyrosine-protein kinase transmembrane receptor ROR1-like
, inactive tyrosine-protein kinase transmembrane receptor ROR1