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The model had 92% sensitivity and 92% specificity. We obtained similar results in the independent validation cohort. AIB1 (zeige NCOA3 Proteine) and EIF5A2 (zeige EIF5A2 Proteine) show promise for the noninvasive detection of bladder cancer. The model based on AIB1 (zeige NCOA3 Proteine), EIF5A2 (zeige EIF5A2 Proteine), and NMP22 outperformed each of the three individual biomarkers for detecting Bladder cancer.
our study implicates that AIB1 (zeige NCOA3 Proteine) is a molecular target of sorafenib and downregulation of AIB1 (zeige NCOA3 Proteine) contributes to the anti-tumor effects of sorafenib
Rac3 regulates breast cancer invasion and metastasis by controlling adhesion and matrix degradation.
our studies illustrate that SRC-3 (zeige NCOA3 Proteine) overexpression is clinically and functionally relevant to the progression of human ESCC.
Data indicate that phosphorylated cortactin recruits Vav2 to activate Rac3 and promote invadopodial maturation in invasive breast cancer cells.
Estrogen receptor (zeige ESR1 Proteine) recruits steroid receptor coactivator (zeige SRA1 Proteine)-3 primary coactivator and secondary coactivators, p300/CBP (zeige CREBBP Proteine) and CARM1 (zeige CARM1 Proteine) to regulate genetic transcription.
we identify a positive feedback regulatory loop consisting of XBP1 (zeige XBP1 Proteine) and NCOA3 (zeige NCOA3 Proteine) that maintains high levels of NCOA3 (zeige NCOA3 Proteine) and XBP1 (zeige XBP1 Proteine) expression in breast cancer tissues.
loss of miR-17 and miR (zeige MLXIP Proteine)-20b enhanced breast cancer resistance to taxol by upregulating NCOA3 (zeige NCOA3 Proteine) levels.
Data (including data from studies of hydrogen-deuterium exchange coupled to mass spectrometry in presence of denaturants) suggest that, for peptide fragments of human ACTR (zeige NCOA3 Proteine) and mouse Crebbp (zeige CREBBP Proteine) representing disordered interaction domains, exchange rates are changed dramatically by high concentrations of denaturants guanidinium chloride or urea. (ACTR (zeige NCOA3 Proteine) = activator of thyroid and retinoid receptor; Crebbp (zeige CREBBP Proteine) = CREB binding protein (zeige CREBBP Proteine))
Data suggest that steroid receptor (zeige ESR2 Proteine) coactivators (NCOA1 (zeige NCOA1 Proteine), NCOA2 (zeige NCOA2 Proteine), NCOA3 (zeige NCOA3 Proteine)) are over-expressed in a number of hormone-dependent cancers where they promote tumor growth, invasion, metastasis, and chemo-resistance; with their multiple roles in cancer, steroid receptor (zeige ESR2 Proteine) coactivators are promising targets for development of antineoplastic agents that can interfere with their function. [REVIEW]
The results of this study show that Rac3 have a roles in the formation of GABAergic circuits, as highlighted by the differential effects of their deletion on the late maturation of specific populations.
This study showed that in the absence of both Rac1 and rac3, the embryonic migration of medial ganglionic eminence-derived interneurons is further impaired.
This study demonistrated that Rac1 and rac3 GTPases control synergistically the development of cortical and hippocampal GABAergic interneurons in mice.
Rac1b forms a complex with NADPH oxidase (zeige NOX1 Proteine) and promotes the production of reactive oxygen species, expression of Snail (zeige SNAI1 Proteine), and activation of the epithelial-mesenchymal transition program.
Activation of epithelial-mesenchymal transition by MMP-induced expression of Rac1b gave rise to lung adenocarcinoma.
Rac1 and Rac3 redundantly regulate many aspects of inner ear morphogenesis, including cell adhesion, cell proliferation, cell death and cell movements.
Rac1 and Rac3 GTPases participate in the normal development of hilar mossy cells.
results support a role for neuronal Rac1 and Rac3 in dictating proper lymphoid organ development, and suggest the existence of lymphoid-extrinsic mechanisms linking neural defects to the loss of immune-competence
These defects result from increased RhoA/ROCK/myosin II activity and blockade of Rac1 signaling.
The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases.
, amplified in breast cancer 1 protein
, class E basic helix-loop-helix protein 42
, receptor-associated coactivator 3
, steroid receptor coactivator protein 3
, thyroid hormone receptor activator molecule 1
, ras-related C3 botulinum toxin substrate 3
, rho family, small GTP binding protein Rac3
, ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)