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Inhibition of PTK7 by siRNA treatment significantly decreases the viability of atypical teratoid rhabdoid tumors (ATRT)patient-derived tumor cell lines.These studies provide the groundwork for future preclinical in vivo studies aiming to investigate the efficacy of PTK7 inhibition on ATRT tumor growth
PTK7 localization and protein stability is affected by canonical Wnt (zeige WNT2 Proteine) ligands.
These findings demonstrate that PTK7 upregulates MMP9 (zeige MMP9 Proteine) through activation of AP-1 (zeige FOSB Proteine) and NF-kappaB (zeige NFKB1 Proteine) and, thus increases invasive properties of ESCC cells.
PTK7 overexpression is associated with esophageal squamous cell carcinoma.
Our data indicate that PTK7 protein expression is associated with the prognosis of oral tongue squamous cell carcinoma
PTK7 expression was correlated with tumor differentiation (P=0.027), lymph node metastasis (P=0.005), distant metastasis (P=0.001) and TNM (zeige ODZ1 Proteine) stage (P=0.028) of colorectal cancer patients
High PTK7 expression is associated with radioresistance in esophageal squamous cell carcinoma.
PTK7 enriches in self-renewing, multipotent stem cells of the human colon.
findings implicate PTK7 as a risk factor for NTDs and provide additional evidence for a pathogenic role of PCP (zeige PRCP Proteine) signaling in these malformations
overexpression in PTK7-negative cancer cells led to increased metastatic events. PTK7 expression thus represents a potential prognostic biomarker and a novel therapeutic target in CRC (zeige CALR Proteine).
PTK7 regulates extracellular matrix integrity and the activity levels of RAC1 and myosin II, which in turn regulates Wolffian duct morphogenesis and therefore, epididymal function.
In a Ptk7-deficient mouse strain, loss of Ptk7 leads to a diminished pool of hematopoietic stem cells but does not affect in vitro or in vivo differentiation. This is correlated with increased quiescence and reduced homing abilities of Ptk7-deficient hematopoietic stem and progenitor cells.
Data suggest that protein tyrosine kinase 7 (PTK7) is essential for Wolffian duct morphogenesis and male fertility.
data demonstrates that PTK7 regulates the activity of KDR (zeige KDR Proteine) biphasically by inducing oligomerization of KDR (zeige KDR Proteine) molecules at lower concentrations and by surrounding KDR (zeige KDR Proteine) molecules at higher concentrations.
PTK7 expression plays an important role in the invasiveness of intrahepatic cholangiocarcinoma cells.
Planar polarity of neural cell motility and intercalation requires Ptk7 function.
acts in conjunction with the noncanonical Wnt pathway to orient epithelial planar cell polarity through modulation of myosin II-based contractile tension between supporting cells and hair cells
The tyrosine kinase receptor (zeige KDR Proteine), PTK7, is implicated in beta-catenin (zeige CTNNB1 Proteine)-dependent developmental processes.
These findings illustrate a novel and pivotal role for Cdx (zeige CDX1 Proteine) function upstream of Ptk7 and neural tube closure in vertebrates.
Chuzhoi mutation, that causes multiple abnormalities maps, to Chromosome 17 and carries a splice site mutation in Ptk7 and causes disruption of Ptk7 protein expression.
This gene encodes a member of the receptor protein tyrosine kinase family of proteins that transduce extracellular signals across the cell membrane. The encoded protein lacks detectable catalytic tyrosine kinase activity, is involved in the Wnt signaling pathway and plays a role in multiple cellular processes including polarity and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
PTK7 protein tyrosine kinase 7
, inactive tyrosine-protein kinase 7
, tyrosine-protein kinase-like 7-like
, colon carcinoma kinase 4
, pseudo tyrosine kinase receptor 7
, tyrosine-protein kinase-like 7
, serum response factor
, protein chuzhoi
, protein-tyrosine kinase 7
, receptor tyrosine kinase-like protein
, kinase-like protein