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anti-Human PPP3CC Antikörper:
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Human Polyclonal PPP3CC Primary Antibody für IHC (p), ELISA - ABIN545080
Bennasser, Badou, Tkaczuk, Bahraoui: Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha. in Virology 2002
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Human Polyclonal PPP3CC Primary Antibody für IHC (p), ELISA - ABIN545079
Gerber, Hall, Miyakawa, Demars, Gogos, Karayiorgou, Tonegawa: Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC, encoding the calcineurin gamma subunit. in Proceedings of the National Academy of Sciences of the United States of America 2003
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PPP3CC rs7431 may alter miRNA binding ability of miR-212 and miR-132, and thus decrease bladder cancer risk.
These findings indicated that the down-regulation of PPP3CC by ZEB1 resulted in activation of NF-kappaB is a critical oncogenic event in gliomas.
The rs2443504 AA genotype was associated with the Glasgow coma score at 3, 6, and 12 months following severe brain injury.
Knockdown of CNAgamma leads to a disruption of synaptic vesicle cycling in hippocampal neurons.
The PPP3CC involved in the regulation of immune system and synaptic plasticity, seems promising for further investigation.
protein level of PPP3CC negatively correlates with the cellular level of IP3, suggesting a regulatory role of PPP3CC in the IP3-Ca2+ signaling pathway
study suggests that NMDA receptor-mediated signalling genes, DAO, PPP3CC, DTNBP1 might be involved in schizophrenia pathogenic mechanisms related to gender
A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
This study demoistrated that PPP3CC are not genetic risk factors for schizophrenia in japanese.
results identify PPP3CC, located at 8p21.3, as a potential schizophrenia susceptibility gene and support the proposal that alterations in calcineurin signaling contribute to schizophrenia pathogenesis
Decreased hippocampal expression of the susceptibility gene PPP3CC in schizophrenia.
PPP3CC may not play a major role in Japanese schizophrenia
The results suggest that PPP3CC gene may be a true susceptibility gene for schizophrenia.
The Polymorphism, Single Nucleotide of ppp3cc is assosciated with schizophrenia.
No significant differences in calcineurin A gamma expression was observed between patients with schizophrenia and normal controls
These data strongly support a recent proposal that a segment at 8p21.3 contains crucial prostate cancer tumor suppressors.
Data suggest that PPP3CC does not elevate the risk of methamphetamine-use disorder in the Japanese population.
Study demonstrates that all CaN isoforms display the same cytoplasmic subcellular distribution and are expressed in each tested cell line, differences in substrate specificities may determine specific physiological functions of the distinct isoforms.
An intrinsic constitutively activated feedforward signaling circuit composed of IkappaBalpha/NF-kappaB(p65), miR-196b-3p, Meis2, and PPP3CC is formed during the emergence of castration-resistant prostate cancer.
this stusy demonstrates that male mice lacking Ppp3cc or Ppp3r2 genes (knockout mice) are infertile, with reduced sperm motility owing to an inflexible midpiece.
PP2B activity was higher with phosphotyrosine in presence of Ca(2+) than with p-NPP. Further experiments, involving calmodulin as a modulator, confirmed phosphotyrosine as a better substrate
Calcineurin is a calcium-dependent, calmodulin-stimulated protein phosphatase involved in the downstream regulation of dopaminergic signal transduction. Calcineurin is composed of a regulatory subunit and a catalytic subunit. The protein encoded by this gene represents one of the regulatory subunits that has been found for calcineurin. Three transcript variants encoding different isoforms have been found for this gene.
CAM-PRP catalytic subunit
, calcineurin, testis-specific catalytic subunit
, calmodulin-dependent calcineurin A subunit gamma isoform
, protein phosphatase 2B, catalytic subunit, gamma isoform
, protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform
, serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
, PP2BA gamma
, protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform (calcineurin A gamma)
, protein phosphatase 3 catalytic subunit gamma
, protein phosphatase 3, catalytic subunit, gamma isoform
, calcineurin A gamma
, protein phosphatase 3, catalytic subunit, gamma isoform-like
, protein phosphatase 3, catalytic subunit, gamma isozyme
, serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like