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Human PDGFC Protein expressed in Wheat germ - ABIN1314504
Okada, Honda, Campbell, Sakai, Yamashita, Takebuchi, Hada, Shirasaki, Takabatake, Nakamura, Sunagozaka, Tanaka, Fausto, Kaneko: Acyclic retinoid targets platelet-derived growth factor signaling in the prevention of hepatic fibrosis and hepatocellular carcinoma development. in Cancer research 2012
There are four platelet-derived growth factor (PDGF (zeige PDGFA Proteine)) genes (PDGFA (zeige PDGFA Proteine), PDGFB (zeige PDGFB Proteine), PDGFC and PDGFD (zeige PDGFD Proteine)) that reside on chromosomes 7, 22, 4 and 11.
We conclude that PDGF (zeige PDGFA Proteine)-CC-induced blood-spinal cord barrier dysfunction can contribute to timing of amyotrophic lateral sclerosis onset
High glucose-mediated induction of PDGF-C via ChREBP (zeige MLXIPL Proteine) in mesangial cells contributes to the development of glomerular mesangial expansion in diabetes.
PDGF-C up-regulation was mediated by the human embryonic lethal abnormal vision-like protein HuR, which stabilizes the PDGF-C transcript by binding to two predicted AU-rich elements (AREs) in the 3'-untranslated region (3'-UTR).
Concomitant upregulation of PDGF-C with VEGF (zeige VEGFA Proteine) in Glioblastoma tumor cells.
The results indicate that PDGF-C upregulation and calpain-3 (zeige CAPN3 Proteine) downregulation are involved in the aggressiveness of malignant melanoma and suggest that modulators of these proteins
Platelet-derived growth factor-C (PDGF-C) induces anti-apoptotic effects on macrophages through Akt (zeige AKT1 Proteine) and Bad phosphorylation.
Data indicate uPA (plau (zeige PLAU Proteine)) and PAI1 (Serpine1 (zeige SERPINE1 Proteine)) were up-regulated in human PDGF-C Tg mice, suggesting that uPA (zeige PRAP1 Proteine) could be compensating for the loss of tissue-type plasminogen activator (tPA (zeige PLAT Proteine)) activity in PDGF-C Tg; tpa (zeige PLAT Proteine) KO mice.
High PDGF-C expression induces progressive fibrosis, chronic inflammation, neoangiogenesis and sinusoidal congestion resulting in hepatocellular carcinoma.
PDGF-C is both angiogenic and a neuronal survival factor, and it is an important component of neurovascular crosstalk. [Review]
Results provide both in vitro and in vivo evidence that Mac-1 (zeige ITGAM Proteine) acting together with LRP1 (zeige LRP1 Proteine) facilitates PDGF (zeige PDGFA Proteine)-CC activation by thrombolytic tissue plasminogen activator (zeige PLAT Proteine) in the neurovascular unit. The requirement of both Mac-1 (zeige ITGAM Proteine) and LRP1 (zeige LRP1 Proteine) for efficient activation of PDGF (zeige PDGFA Proteine)-CC by tPA (zeige PLAT Proteine) provides a novel mechanism that helps limit PDGFRalpha signaling in the neurovascular unit.
PDGF (zeige PDGFA Proteine)-CC neutralization or deficiency was not associated with preservation or accelerated loss of peritubular capillaries, suggesting no significant pro-angiogenic effects of PDGF (zeige PDGFA Proteine)-CC during renal fibrosis
heme oxygenase-1 (HMOX1 (zeige HMOX1 Proteine)) activity is critically required for the vascular protective/survival effect of PDGF (zeige PDGFA Proteine)-CC.
Studied survival and antiapoptotic effects of PDGF-C on focal retinal lesions in Ccl2 (zeige CCL2 Proteine)(-/-)/Cx3cr1 (zeige CX3CR1 Proteine)(-/-) on C57BL/6N [Crb1 (zeige CRB1 Proteine)(rd8)] (DKO rd8) background mice, a model for progressive and focal retinal degeneration.
loss of FREM1 function promotes epidermal blistering in Fraser syndrome as a consequence of reduced PDGFC activity, in addition to its stabilising role in the basement membrane
Study indicates the role for PDGF-C as a critical regulator of impaired angiogenesis of diabetes.
PDGF-C promotes tumor growth via a growth promoting effect on hepatic stellate cells that is dependent on the presence of functional PAK-2 (zeige PAK2 Proteine)
Data identified PDGF (zeige PDGFA Proteine)-CC as an important candidate target gene for antiangiogenic therapy, and PDGF (zeige PDGFA Proteine)-CC inhibition may be of therapeutic value in treating neovascular diseases.
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene.
platelet-derived growth factor C
, platelet-derived growth factor, C polypeptide
, spinal cord-derived growth factor
, secretory growth factor-like protein