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MDK functions in the ventral tegmental area to limit ethanol consumption and levels of CCL2 (zeige CCL2 Proteine)
Analyses of the melanoma secretome and validation in clinical specimens showed that the heparin-binding factor (zeige PTN Proteine) midkine is a systemic inducer of neo-lymphangiogenesis that defines patient prognosis. This role of midkine was linked to a paracrine activation of the mTOR (zeige FRAP1 Proteine) pathway in lymphatic endothelial cells.
MK serves an indispensable role in the NFAT (zeige NFATC1 Proteine)-regulated activation of CD4 (zeige CD4 Proteine)(+) T cells and Th1 (zeige HAND1 Proteine) cell differentiation.
Ethanol engages MDK (and ALK) signaling, which has important consequences for alcohol-induced neurotoxicity.
Mdk plays a crucial role in the early inflammation phase and during the development of cartilaginous callus in the fracture healing process.
This study demonistrated that a differential regulation of specific behavioural responses to ethanol by midkine.
clonidine-induced analgesia was significantly enhanced in PTN (zeige PTN Proteine)-/- mice compared to MK-/- and WT+/+ mice in the tail-immersion test
midkine plays a critical role in cardiac hypertrophy and remodelling.
Midkine exerts a neuroprotective role against amphetamine-induced neurotoxicity in striatum.
MK leads to a blockade of PAI-1 (zeige SERPINE1 Proteine), which is closely associated with the suppression of crescentic glomerulonephritis.
Midkine is involved in bowel inflammation in UC and lymph node metastasis in CRC (zeige CALR Proteine), rendering midkine an attractive target for their treatment.
Data suggest that mature KLK9 (kallikrein 9 (zeige KLK9 Proteine)) is a glycosylated chymotrypsin-like enzyme with strong preference for tyrosine over phenylalanine at P1 cleavage position; substrate specificity of KLK9 (zeige KLK9 Proteine) appears to extend to KLK10 (zeige KLK10 Proteine) and midkine; enzyme activity is enhanced by Mg2 (zeige MUC7 Proteine)+ and Ca2 (zeige CA2 Proteine)+, but is reversibly attenuated by Zn2+; KLK9 (zeige KLK9 Proteine) is inhibited in vitro by many naturally occurring or synthetic protease inhibitors.
midkine may be a good inflammatory marker in renal transplant recipients as in other inflammatory diseases. Moreover, it seems that it is not affected by factors other than inflammation during the post-transplantation period.
MDK plays an important role in non-small cell lung cancer progression and prognosis and may act as a convincing prognostic indicator for non-small cell lung cancer patients.
The concentration of MDK in amniotic fluid declined with gestational age.MDK concentrations in amniotic fluid were far higher than in maternal plasma.
The Circulating Levels of Selenium, Zinc, Midkine, Some Inflammatory Cytokines, and Angiogenic Factors in Mitral Chordae Tendineae Rupture.
overexpression of midkine protein serves as an unfavorable prognostic biomarker in breast cancer patients
our results suggest that midkine expression could be a clinically useful marker in predicting the presence of multiple lymph node metastases in BRAFV600E papillary thyroid carcinoma.
PLSCR1 (zeige PLSCR1 Proteine) positively regulates hepatic carcinoma cell proliferation and migration through interacting with midkine
Use hybrid-type modified chitosan derivative nanoparticles to deliver midkine-siRNA to HepG2 cells.
Data show that 9-cis-retinoic acid enhanced midkine gene expression, but not insulin-like growth factor-I (zeige IGF1 Proteine) gene expression, in cumulus-granulosa cells.
Found that macrophages are the major source of midkine in the atherosclerotic neointima of in-stent restenosis in hypercholesterolemic rabbits.
MK is able to maintain a proliferative PGC (zeige PGC Proteine) phenotype mediated by the suppression of DAZL (zeige DAZL Proteine) in early germ cells
This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed.
, pleiotrophic factor-alpha-2
, pleiotrophic factor-alpha2
, retinoic acid-induced differentiation factor
, amphiregulin-associated protein
, midgestation and kidney protein
, neurite outgrowth-promoting factor 2
, retinoic acid inducible factor
, retinoic acid-induced heparin-binding protein