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anti-Mouse (Murine) MDK Antikörper:
anti-Rat (Rattus) MDK Antikörper:
anti-Human MDK Antikörper:
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Human Polyclonal MDK Primary Antibody für EIA, IHC (fro) - ABIN115508
Hara, Ikeda, Shimada, Nagamine, Sawa, Oda: [Surgical experience of 6 multiple primary lung cancers] in Kyobu geka. The Japanese journal of thoracic surgery 2008
Show all 2 Pubmed References
MDK functions in the ventral tegmental area to limit ethanol consumption and levels of CCL2 (zeige CCL2 Antikörper)
Analyses of the melanoma secretome and validation in clinical specimens showed that the heparin-binding factor (zeige PTN Antikörper) midkine is a systemic inducer of neo-lymphangiogenesis that defines patient prognosis. This role of midkine was linked to a paracrine activation of the mTOR (zeige FRAP1 Antikörper) pathway in lymphatic endothelial cells.
MK serves an indispensable role in the NFAT (zeige NFATC1 Antikörper)-regulated activation of CD4 (zeige CD4 Antikörper)(+) T cells and Th1 (zeige HAND1 Antikörper) cell differentiation.
Ethanol engages MDK (and ALK) signaling, which has important consequences for alcohol-induced neurotoxicity.
Mdk plays a crucial role in the early inflammation phase and during the development of cartilaginous callus in the fracture healing process.
This study demonistrated that a differential regulation of specific behavioural responses to ethanol by midkine.
clonidine-induced analgesia was significantly enhanced in PTN (zeige PTN Antikörper)-/- mice compared to MK-/- and WT+/+ mice in the tail-immersion test
midkine plays a critical role in cardiac hypertrophy and remodelling.
Midkine exerts a neuroprotective role against amphetamine-induced neurotoxicity in striatum.
MK leads to a blockade of PAI-1 (zeige SERPINE1 Antikörper), which is closely associated with the suppression of crescentic glomerulonephritis.
suppression of midkine gene promoted the antitumoral effect of cisplatin on human gastric cell line AGS (zeige JAG1 Antikörper) in vitro and in vivo via Notch (zeige NOTCH1 Antikörper) signaling pathway.
Results revealed that ectopic overexpression of midkine in HCC (zeige FAM126A Antikörper) cell lines with IGF-1R (zeige IGF1R Antikörper) inhibition markedly rescued inhibition of HCC (zeige FAM126A Antikörper) cell proliferation, migration, and invasion. These data imply that inhibition of IGF-1R (zeige IGF1R Antikörper) suppresses HCC (zeige FAM126A Antikörper) growth and invasion via down-regulating midkine expression.
Midkine is involved in bowel inflammation in UC and lymph node metastasis in CRC (zeige CALR Antikörper), rendering midkine an attractive target for their treatment.
Data suggest that mature KLK9 (kallikrein 9 (zeige KLK9 Antikörper)) is a glycosylated chymotrypsin-like enzyme with strong preference for tyrosine over phenylalanine at P1 cleavage position; substrate specificity of KLK9 (zeige KLK9 Antikörper) appears to extend to KLK10 (zeige KLK10 Antikörper) and midkine; enzyme activity is enhanced by Mg2 (zeige MUC7 Antikörper)+ and Ca2 (zeige CA2 Antikörper)+, but is reversibly attenuated by Zn2+; KLK9 (zeige KLK9 Antikörper) is inhibited in vitro by many naturally occurring or synthetic protease inhibitors.
midkine may be a good inflammatory marker in renal transplant recipients as in other inflammatory diseases. Moreover, it seems that it is not affected by factors other than inflammation during the post-transplantation period.
MDK plays an important role in non-small cell lung cancer progression and prognosis and may act as a convincing prognostic indicator for non-small cell lung cancer patients.
The concentration of MDK in amniotic fluid declined with gestational age.MDK concentrations in amniotic fluid were far higher than in maternal plasma.
The Circulating Levels of Selenium, Zinc, Midkine, Some Inflammatory Cytokines, and Angiogenic Factors in Mitral Chordae Tendineae Rupture.
overexpression of midkine protein serves as an unfavorable prognostic biomarker in breast cancer patients
our results suggest that midkine expression could be a clinically useful marker in predicting the presence of multiple lymph node metastases in BRAFV600E papillary thyroid carcinoma.
Data show that 9-cis-retinoic acid enhanced midkine gene expression, but not insulin-like growth factor-I (zeige IGF1 Antikörper) gene expression, in cumulus-granulosa cells.
Found that macrophages are the major source of midkine in the atherosclerotic neointima of in-stent restenosis in hypercholesterolemic rabbits.
MK is able to maintain a proliferative PGC (zeige PGC Antikörper) phenotype mediated by the suppression of DAZL (zeige DAZL Antikörper) in early germ cells
This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed.
, pleiotrophic factor-alpha-2
, pleiotrophic factor-alpha2
, retinoic acid-induced differentiation factor
, amphiregulin-associated protein
, midgestation and kidney protein
, neurite outgrowth-promoting factor 2
, retinoic acid inducible factor
, retinoic acid-induced heparin-binding protein