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both BIM (zeige BCL2L11 Proteine) and BCL2 (zeige BCL2 Proteine) proteins are regulated by LMTK2 in a GSK3beta- and PP1A (zeige PPP1CA Proteine)-dependent manner.
Mutation of the di-acidic export motif led to endoplasmic reticulum retention of LMTK2, and an increase in protein half-life.
Lemur Tyrosine Kinase-2 (LMTK2), negatively regulates androgen-dependent and androgen-independent prostate cancer cell proliferation. In addition, LMTK2 also negatively regulates the androgen receptor (zeige AR Proteine) transcriptional activity.
Data indicate that Lemur tyrosine kinase 2 (LMTK2) localizes at the plasma membrane and co-immunoprecipitates with cystic fibrosis transmembrane conductance regulator (CFTR (zeige CFTR Proteine)) in airway epithelial cells.
The results indicate that lemur tyrosine kinase 2 is an integral membrane protein in which both the amino and carboxyl termini are exposed to the cytoplasm. Moreover, this topology places the kinase active site within the cytoplasm.
We describe a new signalling pathway within the nervous system that links cdk5 (zeige CDK5 Proteine)/p35 (zeige ANXA1 Proteine) with phosphatase-1C and which has implications for a number of neuronal functions and neuronal dysfunction
Low LMTK2 expression is associated with the development of prostate cancer.
Data show that downregulation of myosin VI (zeige MYO6 Proteine) expression results in a significant reduction in PSA (zeige PLAG1 Proteine) and VEGF (zeige VEGFA Proteine) secretion in LNCaP cells, and the intracellular targeting seems to involve myosin VI (zeige MYO6 Proteine)-interacting proteins, GIPC (zeige GIPC1 Proteine) and LMTK2 and Dab2 (zeige DAB2 Proteine).
KPI-2 is a kinase with sites to associate with PP1C and Inh2 to form a regulatory complex that is localized to membranes
Cprk is expressed in a number of tissues but is enriched in brain and muscle; Cprk displays catalytic activity in kinase assays and is itself phosphorylated by cdk5 (zeige CDK5 Proteine)/p35 (zeige ANXA1 Proteine); Cdk5 (zeige CDK5 Proteine)/p35 (zeige ANXA1 Proteine) inhibits cprk activity
The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis.
, apoptosis-associated tyrosine kinase 2
, brain-enriched kinase
, cyclin-dependent kinase 5/p35-regulated kinase
, kinase phosphatase inhibitor 2
, kinase/phosphatase/inhibitor 2
, serine/threonine-protein kinase KPI-2
, serine/threonine-protein kinase LMTK2