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IGF2 gene overexpression in a series of children diagnosed with adrenocortical tumors was not related to any clinical or biological features analyzed here, while IGF1R gene expression was significantly higher in children who presented tumor relapse and metastasis, which was not true for the IGF1R protein expression analyzed by immunohistochemistry. IGF1R overexpression could be indicative of aggressive ACTs in children.
Results show a significant over-expression of EGFR and IGF1R in adrenocortical carcinoma (ACC) tissue.
Data show that single-nucleotide polymorphisms (SNPs) of the IGF1R (rs12423791), and IGF1 (zeige IGF1 Proteine) (rs2162679, rs5742612, rs35767) genes were significantly associated with tumor response to oxaliplatin, 5-fluorouracil, and leucovorin (FOLFOX).
Amla extract (Emblica officinalis, AE) decreases the gene and protein expression of IGF1R, a target of miR (zeige MLXIP Proteine)-375, and SNAIL1 (zeige SNAI1 Proteine), a transcription factor that represses E-cadherin (zeige CDH1 Proteine) expression.
GSK1904529A, a Potent IGF-IR Inhibitor, Reverses MRP1 (zeige MDM4 Proteine)-Mediated Multidrug Resistance
There is an accelerated loss of IGF1R, following loss of UBQLN1 (zeige UBQLN1 Proteine) in lung adenocarcinoma cells.
data show that the GSK3B-FOXO3 (zeige FOXO3 Proteine) pathway is activated after partial hepatectomy, and this may be one of the mechanisms that lead to upregulation of hepatic IGF1R after partial hepatectomy.
selective impairment of IGF-1 (zeige IGF1 Proteine)-induced DNA synthesis in lymphocytes of CDG patients through decreased gene expression and hypoglycosylation of the IGF-1 (zeige IGF1 Proteine) receptor
The INSR (zeige INSR Proteine) purified in n-dodecyl-beta-D-maltoside showed ligand-stimulated autophosphorylation and kinase activity, suggesting an intact transmembrane signaling mechanism.
Our findings suggest a novel mechanism by which CCE procyanidins can promote proteasome-independent degradation of nuclear Nrf2 (zeige GABPA Proteine) through IGF-1R phosphorylation and cysteine protease (zeige CTSB Proteine) activation.
A total of 1169 cows of 4 pure breeds (Polish Holstein Friesian, Montbeliarde, Jersey and Holstein Friesian) were genotyped. The T (IGF1R/e2/MspI) and G (IGF1R/e2/TaqI) alleles were found to be prevalent. 3 combinations of genotypes (TT/GG, TT/AG and CT/GG) were associated with the highest productivity (milk, protein and fat yields) among the breeds studied, as opposed to individuals carrying the worst CC/AA combination.
study determined IGFR1 and PAPP-A (zeige PAPPA Proteine) expression both in follicles at different stages of development and in ovarian cysts; data indicate that animals with cystic ovarian disease (COD (zeige SNRPB Proteine)) have an altered regulation of the IGF system in the ovary and thus allow postulating IGFR1 expression and PAPP-A (zeige PAPPA Proteine) secretion as a modulator of IGF1 (zeige IGF1 Proteine) in cattle with COD (zeige SNRPB Proteine)
Results of the present study showed, for the first time, that the polymorphism in IGF1R is associated with superovulation traits, and indicated that the IGFIR gene can be used as a potential marker for donor selection.
two SNPs in the coding region of the insulin-like growth factor 1 receptor gene may have a role in growth of Angus cattle
insulin (zeige INS Proteine)-like growth factor (IGF) receptor glycosylation is critical to the maintenance of vascular smooth muscle phenotype in the presence of factors promoting osteogenic differentiation and mineralization
The objective of this study was to estimate the allele and genotype frequencies of the IGF-IR/TaqI, m-calpain/HhaI, and UCP-3/BglI polymorphisms and to determine association between these polymorphisms and growth traits in Chinese indigenous cattle breed.
Data describes the long-term changes to skeletal muscle growth and IGF1 (zeige IGF1 Proteine), 2, 1R, and 2R mRNA expression in progeny after exposure to high and low levels of maternal nutrient intake during the first two trimesters of gestation in the bovine.
Results do not support the premise that increased apoptosis associated with high levels of IGF1 (zeige IGF1 Proteine) is mediated via downregulation of the IGF1R as previously found in preimplantation mouse embryos.
IGF-I (zeige IGF1 Proteine) down-regulated functional IGF-I receptor via GSK-3beta inhibition and mTOR (zeige FRAP1 Proteine) activation; constitutive activity of GSK-3beta maintained IGF-I receptor level in nonstimulated cells.
IGF-1 (zeige IGF1 Proteine) and IGF-1r gene polymorphisms in East Anatolian Red and South Anatolian Red cattle breeds.
IGF-I (zeige IGF1 Proteine), IGF-II, and IGFBP-3 (zeige IGFBP3 Proteine) mRNA were positively correlated with IGF-IR from 50E to 180D, suggesting that the expression of IGF-system genes exhibits specific developmental patterns in the skeletal muscle tissues.
IL-1beta (zeige IL1B Proteine) impaired the actions of IGF-I (zeige IGF1 Proteine) at a point distal to the IGF receptor
IGF-1R is expressed in porcine somatostatin (zeige SST Proteine)-containing islet D-cells
This study suggests an association between the affinity of insulin (zeige INS Proteine) receptors and number of IGF-1 (zeige IGF1 Proteine) receptors with placental and/or fetal growth.
mRNA expression of IGF-I receptor
results demonstrate for the first time that Igf1r is important in acute asthma pathobiology and resolution of HDM (zeige HDAC3 Proteine)-induced inflammation
This study found that expressions of Cav3.2 (zeige CACNA1H Proteine) and IGF-1R, and their colocalization were not increased in DRGs of mice following axotomy. In addition, Cav3.2 (zeige CACNA1H Proteine) or IGF-1R subpopulation neurons did not acquire significant switch in expression phenotype after sciatic nerve axotomy.
The present observations indicate that IGF-IR regulates glucose transporter 1 (zeige SLC2A1 Proteine) activity in astrocytes.
Epithelial IGF1R is dispensable for IGF2-mediated enhanced intestinal adaptation after small bowel resection in retinoblastoma-deficient mice.
these data suggest that the decreased mammary gland tumor latency time caused by chronic IGF1R activation is related to modulation of tumor progression rather than increased tumor initiation.
Data show that tumors lacking PSMA had less than half the abundance of type 1 insulin-like growth factor receptor (IGF-1R), less activity in the survival pathway mediated by PI3K-AKT signaling, and more activity in the proliferative pathway mediated by MAPK-ERK1/2 signaling.
let-7g regulates autophagy in mouse granulosa cells by targeting insulin-like growth factor 1 receptor and downregulating protein kinase B (zeige AKT1 Proteine)/mammalian target of rapamycin (zeige FRAP1 Proteine) signaling
VEGF (zeige VEGFA Proteine) and IGF1 (zeige IGF1 Proteine) were critical factors for the spontaneous cardiac differentiation of BATDCs, and MEK (zeige MDK Proteine)/ERK (zeige EPHB2 Proteine) signaling was involved in the role of VEGF (zeige VEGFA Proteine) and IGF1 (zeige IGF1 Proteine).
miR (zeige MLXIP Proteine)-223/IGF-IR signalling pathway is regulated in parallel in both the lung vasculature and the right ventricle under conditions of hypoxia induced pulmonary hypertension.
This study evaluated the expression of IGF-1 (zeige IGF1 Proteine) receptor, insulin receptor (zeige INSR Proteine) AND IGF-1 (zeige IGF1 Proteine) in the lammelar tissue of horses with insulin (zeige INS Proteine)-induced hyperinsulinemia.
The laminar cell types expressing insulin receptor (zeige INSR Proteine) and/or insulin-like growth factor-1 receptor and the effect of dietary carbohydrates on their expression are reported.
Somatomedin (IGF-I (zeige IGF1 Proteine)) is localized in equine spermatogenic and Leydig cells, and IGF-I receptor is present in spermatogonia, spermatocytes and Leydig cells.[IGF-I receptor]
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.
, insulin-like growth factor I receptor
, soluble IGF1R variant 1
, soluble IGF1R variant 2
, insulin-like growth factor receptor tyrosine kinase
, insulin-like growth factor-I receptor
, type 1 IGF receptor
, tyrosine kinase
, IGF-1 receptor
, insulin-like growth factor 1 receptor beta subunit
, insulin-like growth factor receptor 1
, insulin-like growth factor-1 receptor
, receptor tyrosine kinase
, insulin-like growth factor 1 receptor
, line 186
, insulin-like growth factor-1 receptor beta subunit