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Human HER2 Protein expressed in Human Cells - ABIN2001860
Yamamoto, Ikawa, Akiyama, Semba, Nomura, Miyajima, Saito, Toyoshima: Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor. in Nature 1986
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Human HER2 Protein expressed in Wheat germ - ABIN1353011
He, Qu, Shen, Tan, Zeng, Liu, Jiang, Li: Highly specific recognition of breast tumors by an RNA-cleaving fluorogenic DNAzyme probe. in Analytical chemistry 2015
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Human HER2 Protein expressed in HEK-293 Cells - ABIN2181214
NDong, Tate, Kett, Batra, Demidenko, Lewis, Hoopes, Gerngross, Griswold: Tumor Cell Targeting by Iron Oxide Nanoparticles Is Dominated by Different Factors In Vitro versus In Vivo. in PLoS ONE 2015
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Human HER2 Protein expressed in HEK-293 Cells - ABIN2181216
Piechocki, Wu, Jones, Jacob, Gibson, Ethier, Abrams, Yagita, Venuprasad, Wei: Induction of proapoptotic antibodies to triple-negative breast cancer by vaccination with TRAIL death receptor DR5 DNA. in International journal of cancer. Journal international du cancer 2012
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Human HER2 Protein expressed in Human Cells - ABIN2001858
Lai, Lemke: An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system. in Neuron 1991
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Safety of pertuzumab supplementation in patients with HER2-positive metastatic breast cancer.
ERBB2 may have a role in progression of non-muscle-invasive bladder cancers
Vinorelbine/gemcitabine appeared to be a more valuable first-line treatment regimen than vinorelbine/cisplatin in anthracycline- and taxane-pretreated patients with HER2-negative advanced breast cancer.
This study reports the novel findings that HER2 increases PARP1 (zeige PARP1 Proteine) protein via suppression of the let-7a miRNA, which regulates the PARP1 (zeige PARP1 Proteine) 3'-UTR. Moreover, HER2 status correlates with high PARP1 (zeige PARP1 Proteine) and low let-7a in breast cancer clinical specimens.
Both ERBB2 and ERBB3 (zeige ERBB3 Proteine) are essential for normal proliferation of skin keratinocytes, but in contrast to ERBB3 (zeige ERBB3 Proteine), ERBB2 is essential for migration of human keratinocytes.
Study showed that 25 % of patients with bladder transitional cell carcinoma has Her2/neu over-expression. This Her2/neu (over-expression/amplification) status was significantly associated with disease aggressiveness and poor outcome.
Relapse-free survival (RFS) was significantly shorter in patients who were double positive for EGFR (zeige EGFR Proteine) and HER2. Our results suggest that EGFR (zeige EGFR Proteine) and HER2 are potential therapeutic targets and that their co-expression is a prognostic factor for cervical adenocarcinoma.
ERBB2 methylation status in myocardial tissue contributes to a fraction of the variability in cardiac ERBB2 expression. This study provides a foundation to test whether differential DNA methylation (zeige HELLS Proteine) status in the proximal promoter region of ERBB2 impacts on the cardiotoxic potential of trastuzumab by modifying the intracellular dynamics of ERBB2.
There is a small, distinct category of HER2-positive CRC (zeige CALR Proteine) patients who are candidates for HER2-targeted therapy. CGS has the same sensitivity as IHC and FISH for detecting HER2-positive patients.
An interdisciplinary German expert group took the challenges of HER2 testing in gastric cancer as an opportunity to address essential aspects and questions for the practical use of HER2 testing in this indication from the perspective of pathologists and therapists.
sought to further echocardiographically characterize the ErbB2(tg) mouse line as a model of hypertrophic obstructive cardiomyopathy
investigations revealed that NUMB (zeige NUMB Proteine) and NUMBL (zeige NUMBL Proteine) interacted with small GTPase (zeige RACGAP1 Proteine) Rab7 (zeige RAB7A Proteine) to transition ERBB2 from early to late endosome for degradation.
Combined targeting of TGF-beta (zeige TGFB1 Proteine), EGFR (zeige EGFR Proteine) and HER2 signaling suppresses lymphangiogenesis and metastasis in a pancreatic ductal adenocarcinoma model.
The conjugation of benzylguanine-modified auristatin F to EGFR (zeige EGFR Proteine)-specific 425(scFv)-SNAP and HER2-specific alphaHER2(scFv)-SNAP resulted in two potent recombinant antibody-drug conjugates that specifically killed breast cancer cell lines by inducing apoptosis when applied at nanomolar concentrations.
ErbB2 is required for neonatal cardiomyocyte proliferation. ErbB2 conditional knockout heart exhibited an upregulation of negative cell cycle regulators.
Despite previous evidence suggesting that ErbB (zeige EGFR Proteine) receptors can bind and activate IRSs, our findings indicate that ErbB2 does not cooperate with the IRS (zeige IARS Proteine) pathway in mouse breast cancer model.
It was suggested that transgenic HER-2/neu involves in initiation of malignization of mammary epithelial cells but also in acceleration of age-related hormonal and metabolic changes in turn promoting mammary carcinogenesis
Study showed that suppression of STAT3 (zeige STAT3 Proteine), STAT5 (zeige STAT5A Proteine), and STAT6 (zeige STAT6 Proteine) and overexpression of the proapoptotic factor STAT1 (zeige STAT1 Proteine), which provides p53 (zeige TP53 Proteine)-mediated apoptosis, are the causes for increasing the number of apoptotic neurons in physiological aging. HER-2 tyrosine kinase receptor (zeige KDR Proteine) overexpression promotes neuronal survival through activation of STAT (zeige STAT1 Proteine)-signaling pathway with simultaneous suppression of the proapoptotic factor STAT1 (zeige STAT1 Proteine)
that myocardial ErbB2 and beta-adrenergic receptors signalling are linked in a feedback loop with beta-adrenergic receptors activation leading to increased ErbB2 expression and activity
Metformin inhibits breast tumor angiogenesis and suggest role of HIF-1alpha (zeige HIF1A Proteine)-VEGF (zeige VEGFA Proteine) signaling axis in mediating HER2-induced tumor angiogenesis.
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
receptor tyrosine-protein kinase erbB-2
, Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog)
, NEU proto-oncogene
, epidermal growth factor receptor-related protein
, proto-oncogene NEU
, proto-oncogene c-ErbB-2
, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
, c-erb B2/neu protein
, metastatic lymph node gene 19 protein
, neuro/glioblastoma derived oncogene homolog
, neuroblastoma/glioblastoma derived oncogene homolog
, proto-oncogene Neu
, tyrosine kinase-type cell surface receptor HER2
, Neu oncogene
, avian erythroblastosis oncogene B 2