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Human FLT3LG Protein expressed in Escherichia coli (E. coli) - ABIN413275
Staron, Yang, Liu, Li, Shen, Zúñiga-Pflücker, Aguila, Goldschneider, Li: gp96, an endoplasmic reticulum master chaperone for integrins and Toll-like receptors, selectively regulates early T and B lymphopoiesis. in Blood 2010
Mouse (Murine) FLT3LG Protein expressed in Escherichia coli (E. coli) - ABIN809712
McCoy, Golden, Doll, Yang, Kaba, Burkhard, Lanar: Mechanisms of protective immune responses induced by the Plasmodium falciparum circumsporozoite protein-based, self-assembling protein nanoparticle vaccine. in Malaria journal 2013
Data show that FLT3 ligand (FLT3L) enhances thymopoiesis through increased survival and export of hematopoietic stem cell (Lin([minus])Sca1 (zeige ATXN1 Proteine)(+)c-Kit(+) [LSK (zeige LCK Proteine)] cells via CXCR4 (zeige CXCR4 Proteine) receptor regulation.
these results demonstrate that the lack of Flt3L mRNA expression in hematopoietic stem cells is yet another marker which further defines the status of long-term repopulating -hematopoietic stem cells
this study shows that ionizing radiation induces a decrease of CD8 (zeige CD8A Proteine)+ dendritic cells and Th1 (zeige HAND1 Proteine)/Th2 shift, which was reversed by Flt3 ligand treatment, suggesting a novel mechanism for radiation-induced immunosuppression
may be mediated by Flt3L- and MMP-9 (zeige MMP9 Proteine)-dependent mobilization of dendritic cells
Bone marrow-derived CD117+ hematopoietic progenitor cells differentiate into thymic dendritic cells in the fetal thymus organ culture system in the presence of Flt3L.
Flt3L significantly contributes to innate lymphoid cells and Peyer's patches development by targeting lymphoid progenitor cells during fetal and adult life.
unlike G-CSF (zeige CSF3 Proteine), Flt3 (zeige FLT3 Proteine)-L had an indirect effect on EI macrophages, as it was not detected at the surface of EI macrophages or erythroid progenitors.
Study showed shown Flt3L-dependent accumulation of a population of DNGR-1(CLEC9A (zeige CLEC9A Proteine))-EGFP+ CD45h CD11blow MHCII+ myeloid cells in the brain
Data indicate that Flt3 ligand knockout (Flt3L-/-) mice are unable to control infection with Toxoplasma gondii.
inhibition of the calcineurin-nuclear factor of activated T cells pathway enhances the proliferation of granulocyte-monocyte progenitors both in vitro and in vivo
The cytokine Fms-like tyrosine kinase 3 ligand is an important regulator of hematopoiesis. Its receptor, Flt3 (zeige FLT3 Proteine), is expressed on myeloid, lymphoid and dendritic cell progenitors and is considered an important growth and differentiation factor for several hematopoietic lineages. [review]
Results elucidated a novel resistance mechanism that FL attenuated inhibitory effects of FLT3 (zeige FLT3 Proteine) inhibitors mainly through the activation of Wt-FLT3 (zeige FLT3 Proteine), not mutated FLT3 (zeige FLT3 Proteine) in acute myeloid leukemia (zeige BCL11A Proteine).
it is likely that TGFbeta1 (zeige TGFB1 Proteine) and FL, both abundantly produced by bone marrow stromal cells, function in a coordinated manner to render mixed-lineage leukemia gene-rearranged acute lymphoblastic leukemia cells chemoresistant
Pre-treatment serum levels of FLT3 (zeige FLT3 Proteine)-L were higher than controls. FLT3 (zeige FLT3 Proteine)-L correlated positively with all soluble angiogenic factors, as well with bone marrow microvascular density. Post-treatment FLT3 (zeige FLT3 Proteine)-L decreased significantly in responders to therapy.
The immunohistochemical expression of caveolin-1 (zeige CAV1 Proteine) and podocalyxin (zeige PODXL Proteine) in lungs from rats challenged with a 2-kDa macrophage-activating lipopeptide (MALP-2) and Flt3L, was examined.
The Flt3L/CD135 (zeige FLT3 Proteine) axis is active in rheumatoid arthritis
Flt3L enhances global T cell and humoral immunity as well as both the numbers and antigen capture capacity of migratory dendritic cells and classical lymphoid-resident dendritic cells
Administration of the hematopoietic growth factor (zeige IL-3 Proteine) Flt3L to human subjects increases the frequency and absolute number of Treg cells.
Human bone marrow stromal cells simultaneously support B and T/NK lineage development from human haematopoietic progenitors: a principal role for flt3 ligand in lymphopoiesis.
A novel dendritic cell(DC) progenitor regulatory pathway in which PGE (zeige LIPF Proteine)(2) signaling through EP1 (zeige PTGER1 Proteine)/EP3 (zeige PTGER3 Proteine) receptors regulates Flt3 (zeige FLT3 Proteine) expression and downstream STAT3 (zeige STAT3 Proteine) activation and survivin (zeige BIRC5 Proteine) expression, required for optimal progenitor survival and differentiation.
Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE\; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al., 2010
, flt3 ligand
, fms-related tyrosine kinase 3 ligand
, fms-like tyrosine kinase 3 ligand