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This is the first report demonstrating the spatiotemporal expression patterns of Flk1 (zeige KDR Proteine) and Flt1 in the coronary vascular system during development and after MI; thus, this study suggests that these factors have distinct and important functions in coronary angiogenesis.
sFlt-1 overexpression in Padi4 (zeige PADI4 Proteine)(-/-) mice resulted in dramatically lower inflammatory and thrombotic response, which was accompanied by significant reduction in pregnancy losses. Inhibition of NETosis may serve as a novel target in disorders of impaired placentation.
endothelial dysfunction due to high circulating sFLT1 may be the primary event leading to enhanced vasoconstrictor sensitivity that is characteristic of preeclampsia
Flt1 has a role in blood vessel anastomosis during angiogenesis
First-in-class selective PET tracers for imaging VEGFR-1 and VEGFR-2 (zeige KDR Proteine) were constructed and successfully validated in an orthotopic murine tumor model.
these results suggest that VEGFR1 signaling plays a role in regulating the balance between macrophage phenotypes in streptozotocin -induced diabetic wounds, prevents impaired diabetic wound healing, and promotes angiogenesis/lymphangiogenesis.
These data therefore support a tightly controlled, paracrine signaling mechanism of VEGF-B (zeige VEGFB Proteine) to VEGFR1.
Flt1/VEGF-A (zeige VEGFA Proteine) signalling has stage-specific effects on vascular morphogenesis.
IL-35 treatment reduced collagen-induced arthritis via inhibiting vascular endothelial growth factor and its receptors
the VEGFR-1 tyrosine kinase (zeige TYRO3 Proteine) signaling has an effect on angiogenesis.
Icrucumab and ramucirumab are recombinant human IgG1 monoclonal antibodies that bind vascular endothelial growth factor (VEGF) receptors 1 and 2 (VEGFR-1 and -2), respectively. VEGFR-1 activation on endothelial and tumor cell surfaces increases tumor vascularization and growth and supports tumor growth via multiple mechanisms, including contributions to angiogenesis and direct promotion of cancer cell proliferation.
Cases with high MDSC infiltration, which was inversely correlated with intratumoral CD8(+) T-cell infiltration, exhibited shorter overall survival. In a mouse model, intratumoral MDSCs expressed both VEGFR1 and VEGFR2. VEGF expression in ovarian cancer induced MDSCs, inhibited local immunity, and contributed to poor prognosis
Circulating tissue transglutaminase is associated with sFlt-1, soluble endoglin and VEGF in the maternal circulation of preeclampsia patients, suggesting that tTG may have a role in the pathogenesis of PE.
The authors observed direct damage caused by sFLT1 in tumour cells. They exposed several kinds of cells derived from ovarian and colorectal cancers as well as HEK293T cells to sFLT1 in two ways, transfection and exogenous application. The cell morphology and an lactate dehydrogenase assay revealed cytotoxicity.
Altered antiangiogenic state because of altered circulating sFlt1 leads to Preeclampsia, ratio of sFlt1/PlGF (zeige PGF Proteine) correlates with Preeclampsia phenotypes.
Gestation-adjusted sEng, sFlt-1 and PlGF (zeige PGF Proteine) levels were 11%, 36%, and 30%, respectively, lower in women who later suffered miscarriage compared with unaffected pregnancies
the optimal discrimination cut-off for each cytokine: sVEGFR-1 (2124.5pg/mL), IL-6 (zeige IL6 Proteine) (40.2pg/mL), VEGF-A (zeige VEGFA Proteine) (1060.1pg/mL), Angiopoeintin-2 (913.7pg/mL), uPA (zeige PRAP1 Proteine) (248.1pg/mL), sHER-2/neu (zeige ERBB2 Proteine) (5010pg/mL) and PLGF (zeige PGF Proteine) (93.4pg/mL). For the very first time, a novel cytokine profile associated with cancer metastasis to the paratracheal lymph nodes were reported.
Results indicate that miR (zeige MLXIP Proteine)-507 represented potential therapeutic targets in breast cancer by modulating fms-related tyrosine kinase-1 (Flt-1).
VEGF (zeige VEGFA Proteine)-Flt-1 signaling induces osteoclastogenesis in OSCC through two possible ways: 1) VEGF (zeige VEGFA Proteine) produced from OSCC cells can directly stimulate the Flt-1 pathway in preosteoclasts to induce migration to future bone resorbing area and differentiation into osteoclasts, and 2) VEGF (zeige VEGFA Proteine)-Flt-1 signaling upregulates RANKL (zeige TNFSF11 Proteine) expression in OSCC cells, which indirectly leads to osteoclast differentiation
Study demonstrates that placental-specific overexpression of hsFlt-1 alters placental morphology and trophoblast differentiation and interferes with IGF2 and nutrient transporter expression leading to intrauterine growth restriction.
There is a possibility that steatosis can be suppressed by the CC genotype in VEGFR1.
These results suggest that non-dominant follicles maintain a greater concentration of the mRNA expression of both membrane and soluble VEGF receptors; but follicular dominance is related to a reduction in the mRNA expression of sVEGFR1 and sVEGFR2.
VEGFR-1 negatively regulates primary bovine retinal pericytes survival, and its blockade protects the blood-brain barrier integrity.
gamma-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1
VEGFR1 mRNA expression was lower at estrus and at the early I and early II luteal stages than at the other stages, whereas VEGFR1 protein expression did not change significantly throughout the estrous cycle (P<0.05)
Alterations in the expression of VEGF-A (zeige VEGFA Proteine) and bFGF (zeige FGF2 Proteine) systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.
inhibition of VEGFR-1 results in decrease in number of capillary connections indicating VEGFR-1 ligands promote branching angiogenesis.
TGF-beta1 (zeige TGFB1 Proteine) induction of VEGFR-1 in endothelial cells explains pericyte protection of vessels and the selective vulnerability of neonatal vessels to oxygen(VEGFR-1)
the activation of VEGFR-1 and VEGFR-2 (zeige KDR Proteine) heterodimer (VEGFR-1/R-2) is essential for PGI(2 (zeige PTGIR Proteine)) synthesis mediated by VEGF-A (zeige VEGFA Proteine)(165) and VEGF-A (zeige VEGFA Proteine)(121), which cannot be reproduced by the parallel activation of VEGFR-1 and VEGFR-2 (zeige KDR Proteine) homodimers with corresponding agonists
PEDF (zeige SERPINF1 Proteine) and VEGFR-1 have roles in the negative regulation of angiogenesis
we analyzed the expression and cellular distribution of Flt-1(VEGFR-1) and Flk-1 (KDR/VEGFR-2 (zeige KDR Proteine))in newborn piglet brain
data shows that members of the VEGF (zeige VEGFA Proteine)-VEGFR (zeige KDR Proteine) system are temporally and spatially well localized for playing key roles during umbilical cord formation and its intensive growth observed after day 75 of pregnancy
The VEGFR1 was stably expressed during the whole lifespan of mesonephric glomeruli, and VEGFR1 is important for the maintenance of endothelial fenestrations.
increased placental expression of the VEGF receptor system is associated with increased placental vascular density observed with the advancement of gestation in the pig.
EGFR (zeige EGFR Proteine), VEGFR (zeige KDR Proteine) and FGFR (zeige FGFR2 Proteine) are expressed in porcine oviduct and endometrium during the time of implantation [review]
VEGF ligand-receptor system may play an important role in the development and maintenance of the corpus luteum in pigs.
VEGF (zeige VEGFA Proteine)/Flk-1 (zeige KDR Proteine)/Flt-1 system is activated during myocardial ischemia reperfusion injury.
Hemodialysis graft placement leads to early increases in wall shear stress, VEGF-A (zeige VEGFA Proteine), pro-MMP-9 (zeige MMP9 Proteine), MMP-2 (zeige MMP2 Proteine), VEGFR-1, VEGFR-2 (zeige KDR Proteine), and TIMP-1 (zeige TIMP1 Proteine), which may contribute to the development of venous stenosis.
in experimental intervertebral disc degeneration, VEGF receptors were expressed in the damaged disc and paradiscal tissues
we determined that radial glia control this process via the Vegf (zeige VEGFA Proteine) decoy receptor sFlt1: sflt1 mutants exhibit the venous over-sprouting observed in radial glia-ablated larvae, and sFlt1 overexpression rescues it. Genetic mosaic analyses show that sFlt1 function in trunk endothelial cells can limit their over-sprouting.
Flt1-tyrosine kinase (TK) activity contributed significantly in endothelial cells survival and vascular development during embryo angiogenesis in zebrafish by engaging PI3K/Akt (zeige AKT1 Proteine) pathway.
Elevated Notch (zeige NOTCH1 Proteine) signaling downstream of perturbed VEGF (zeige VEGFA Proteine) signaling contributes to aberrant flt-1(-/-) blood vessel formation.
Data indicate that the increase in FLT1/sFLT1 protein levels upon miR-10 (zeige LILRB2 Proteine) knockdown inhibited the angiogenic behavior of endothelial cells largely by antagonizing vascular endothelial growth factor receptor 2 (zeige KDR Proteine) signaling.
This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.
fms-like tyrosine kinase 1
, fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
, tyrosine-protein kinase FRT
, tyrosine-protein kinase receptor FLT
, vascular endothelial growth factor receptor 1
, vascular permeability factor receptor
, FMS-like tyrosine kinase 1
, Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
, vascular endothelial growth factor receptor-1
, fms-related tyrosine kinase 1
, receptor tyrosine kinase Flt1b
, soluble fms-like tyrosine kinase 1
, embryonic receptor kinase 2
, vascular endothelial growth factor/vascular permeability factor receptor
, ascular endothelial growth factor/vascular permeability factor receptor
, vascular endothelial growth factor 1
, flt-1 type VEGF receptor