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Alterations in the expression of VEGF-A (zeige VEGFA Proteine) and bFGF (zeige FGF2 Proteine) systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.
These findings suggest that high levels of FGFR4 can increase glucose metabolism and lead to chemoresistance in breast cancer and reveal the mechanistic basis for targeting FGFR4 as a therapeutic opportunity for chemoresistant tumors.
Taken together, this study provides the first evidence that Blu9931 functions as a FGFR4-selective inhibitor in colorectal cancer (CRC (zeige CALR Proteine)) cells, and Blu9931 may be a new targeted drug.
Results show that FGFR4 promotes gastric cancer cell proliferation, migration and epithelial-to-mesenchymal transition. Its expression is negatively regulated by miR (zeige MLXIP Proteine)-491-5p through SNAIL protein (zeige SNAI1 Proteine).
Our findings indicate that the FGFR4-388Arg variant may play an important role in lung squamous cell carcinoma, which may be mediated by the overactivation of the MAPK (zeige MAPK1 Proteine) pathway.
FGFR4 rs351855 could be a novel independent prognostic factor of BCR (zeige BCR Proteine) after radical prostatectomy in the Chinese population.
This meta-analysis demonstrates the FGFR (zeige FGFR2 Proteine) rs351855 G>A polymorphism is associated with increased cancer risk.
Our results indicate that mRNA expression of FGFR4-related genes may be a biomarker to define the distinctive molecular phenotype of intrahepatic cholangiocarcinoma
The present study employed FGFR4 polymorphism to help identify treatments for high risk patients with stage III colon cancer.
Our data indicate that FGFR4 polymorphic isoforms mediate signaling that yields mitochondrial therapeutic targets of relevance to the actions of different somatostatin (zeige SST Proteine) analogs.
In radiosensitive SW480 and DLD1 cells, enforced expression of FGFR4 stabilized RAD51 (zeige RAD51 Proteine) protein levels resulting in enhanced clearance of gamma-H2AX (zeige H2AFX Proteine) foci and increased cell survival in the mismatch repair (MMR (zeige MRC1 Proteine))-proficient SW480 cells.
ileal FGF15/19 to hepatic FGFR4 axis is activated and promotes liver regeneration (LR) after partial hepatectomy (PH) in mice, supporting the potential of ileal FGF15/19 to hepatic FGFR4 axis-targeted therapy to enhance LR after PH
FRS2alpha (zeige FRS2 Proteine)-mediated pathways are essential for the FGF15/FGF19-FGFR4 signaling axis to control bile acid homeostasis.
Results indicate that FGFR4 is an important growth signal receptor in gastric cancer cells with high FGFR4 expression.
The findings suggest that the primary role of Fgfr3 (zeige FGFR3 Proteine) and Fgfr4 is to control the orderly formation of elastin (zeige ELN Proteine) fibers. In a normal lung, FGFR3 (zeige FGFR3 Proteine) and FGFR4 restrict the expression of MFAP5 (zeige MFAP5 Proteine), among other elastogenesis factors.
FGF23 (zeige FGF23 Proteine) augments pro-fibrotic signalling cascades in injury-primed renal fibroblasts via activation of FGFR4
the localization of FGF9 and its receptors at different embryonic and postnatal stages in mice testes, was examined.
Blocking FGFR4 inhibits cardiac calcineurin/NFAT (zeige NFATC1 Proteine) signaling and attenuates the development of LVH and cardiac fibrosis in a well-established animal model of CKD without significantly altering kidney function, blood pressure, or FGF23 (zeige FGF23 Proteine) levels.
The FGFR4 transmembrane polymorphic variants can modulate cellular growth and sensitivity to glucocorticoid hormone negative feedback.
FGFR4 deficiency in mice leads to improvement in glucose metabolism, insulin (zeige INS Proteine) sensitivity, and reduction in body weight under high fat conditions.
The FGFR4-R388 allele yields a receptor variant that preferentially promotes STAT3 (zeige STAT3 Proteine)/5 signaling.
Fgfr4 mediates a signal-transduction pathway between Wnt16 (zeige WNT16 Proteine) and Dlc, but not Dld, to regulate haematopoietic stem cells specification.
The analysis of receptor-ligand interactions between D. rerio fgf8 (zeige FGF8 Proteine) and its receptors, fgfr1 (zeige FGFR1 Proteine) and fgfr4, using combined spectroscopy methods are reported.
The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.
fibroblast growth factor receptor 4
, FGF receptor 4
, hydroxyaryl-protein kinase
, protein-tyrosine kinase
, tyrosine kinase related to fibroblast growth factor receptor
, tyrosylprotein kinase
, CTLA-2-beta protein
, fibroblast growth factor receptor 4 16 minus form
, protein-tyrosine kinase receptor MPK-11
, fibroblast growth factor receptor FREK
, fibroblast growth factor receptor-like embryonic kinase
, fibroblast growth factor receptor 4c