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Alterations in the expression of VEGF-A (zeige VEGFA Proteine) and bFGF (zeige FGF2 Proteine) systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.
Our data indicate that FGFR4 polymorphic isoforms mediate signaling that yields mitochondrial therapeutic targets of relevance to the actions of different somatostatin (zeige SST Proteine) analogs.
In radiosensitive SW480 and DLD1 cells, enforced expression of FGFR4 stabilized RAD51 (zeige RAD51 Proteine) protein levels resulting in enhanced clearance of gamma-H2AX (zeige H2AFX Proteine) foci and increased cell survival in the mismatch repair (MMR (zeige MRC1 Proteine))-proficient SW480 cells.
FGFR4/FGF19 (zeige FGF19 Proteine) autocrine signaling mediates the survival of a subset of basal-like breast cancer cells
Study shows that loss of FGFR4 expression led to a remarkable increase in sorafenib-induced ROS (zeige ROS1 Proteine) generation and apoptosis of hepatocellular carcinoma (HCC (zeige FAM126A Proteine)) cell lines, and demonstrates that hyperactivation of FGF19 (zeige FGF19 Proteine)/FGFR4 signaling in HCC (zeige FAM126A Proteine) is one of the main mechanisms of sorafenib resistance.
This is the first study to elucidate FGF19 (zeige FGF19 Proteine)/FGFR4 signaling in favor of hepatocellular carcinoma cells developing from fatty liver
High expression of FGFR4 is associated with hepatocellular carcinoma.
Findings show that FGF19 (zeige FGF19 Proteine) provides a cytoprotective role against ER stress by activating a FGFR4-GSK3beta-Nrf2 (zeige GABPA Proteine) signaling cascade, suggesting targeting this signaling node as a candidate therapeutic regimen for hepatocellular carcinoma (HCC (zeige FAM126A Proteine)) management.
FGF23 (zeige FGF23 Proteine) augments pro-fibrotic signalling cascades in injury-primed renal fibroblasts via activation of FGFR4
functional clathrin-mediated endocytosis is required for proper FGFR4 signaling
The frequent expression of members of the FGFR (zeige FGFR2 Proteine) family in cervical cancer suggests they may have prognostic and therapeutic relevance.
The findings suggest that the primary role of Fgfr3 (zeige FGFR3 Proteine) and Fgfr4 is to control the orderly formation of elastin (zeige ELN Proteine) fibers. In a normal lung, FGFR3 (zeige FGFR3 Proteine) and FGFR4 restrict the expression of MFAP5 (zeige MFAP5 Proteine), among other elastogenesis factors.
the localization of FGF9 and its receptors at different embryonic and postnatal stages in mice testes, was examined.
Blocking FGFR4 inhibits cardiac calcineurin/NFAT (zeige NFATC1 Proteine) signaling and attenuates the development of LVH and cardiac fibrosis in a well-established animal model of CKD without significantly altering kidney function, blood pressure, or FGF23 (zeige FGF23 Proteine) levels.
The FGFR4 transmembrane polymorphic variants can modulate cellular growth and sensitivity to glucocorticoid hormone negative feedback.
FGFR4 deficiency in mice leads to improvement in glucose metabolism, insulin (zeige INS Proteine) sensitivity, and reduction in body weight under high fat conditions.
The FGFR4-R388 allele yields a receptor variant that preferentially promotes STAT3 (zeige STAT3 Proteine)/5 signaling.
study shows FGFR4 is specifically up regulated by PAX3 (zeige PAX3 Proteine)-FOXO1 (zeige FOXO1 Proteine); however this FGFR4 over expression does not contribute to PAX3 (zeige PAX3 Proteine)-FOXO1 (zeige FOXO1 Proteine) tumorigenic phenotypes in primary skeletal muscle myoblasts
findings suggest a modulatory role for FGFR4 in the development and progression of hepatocellular carcinoma and that FGFR4 may be an important and novel therapeutic target in treating this disease
Differential specificity of endocrine FGF19 (zeige FGF19 Proteine) and FGF21 (zeige FGF21 Proteine) to FGFR1 (zeige FGFR1 Proteine) and FGFR4 in complex with KLB (zeige KLB Proteine).
Fgfr4 mediates a signal-transduction pathway between Wnt16 (zeige WNT16 Proteine) and Dlc, but not Dld, to regulate haematopoietic stem cells specification.
The analysis of receptor-ligand interactions between D. rerio fgf8 (zeige FGF8 Proteine) and its receptors, fgfr1 (zeige FGFR1 Proteine) and fgfr4, using combined spectroscopy methods are reported.
The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.
fibroblast growth factor receptor 4
, FGF receptor 4
, hydroxyaryl-protein kinase
, protein-tyrosine kinase
, tyrosine kinase related to fibroblast growth factor receptor
, tyrosylprotein kinase
, CTLA-2-beta protein
, fibroblast growth factor receptor 4 16 minus form
, protein-tyrosine kinase receptor MPK-11
, fibroblast growth factor receptor FREK
, fibroblast growth factor receptor-like embryonic kinase
, fibroblast growth factor receptor 4c