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Mandibular growth in children with FGFR2 mutations is not normal with impairments found in forward sagittal growth and skull base widening
Inhibiting Fgf-R partly reversed alphavbeta3 integrin activity in Mll (zeige MLL ELISA Kits)-Ell (zeige ELL ELISA Kits)+ progenitor cells.
In gastric cancer, FGFR2 protein overexpression predicts gene amplification and poor survival.
Her2 (zeige ERBB2 ELISA Kits), cMet and FGFR2 statuses were profiled in gastric cancer (GC) patients and the -derived tumor xenograft(PDX) models.
Studies indicate that therapeutically targeting FGF2 (zeige FGF2 ELISA Kits) and FGFR has been extensively assessed in multiple preclinical studies and numerous drugs and treatment options have been tested in clinical trials.
We demonstrate that the bent bone dysplasia syndrome mutations in FGFR2 p.M391R and p.Y381D augment the ability of FGFR2 to epigenetically activate rDNA. Mutations p.M391R and p.Y381D activate the p53 (zeige TP53 ELISA Kits) nucleolar stress response pathway and alter FGFR2-mediated activation of ribosome biogenesis.
Polyclonal secondary FGFR2 mutations represent an important clinical resistance mechanism to protein kinase (zeige CDK7 ELISA Kits) inhibitors in patients with FGFR2 fusion-positive cholangiocarcinoma.
CD44 (zeige CD44 ELISA Kits) and FGFR2 maintain stemness in gastric cancer by differentially regulating c-Myc (zeige MYC ELISA Kits) transcription.
FGFR2, TWIST1 (zeige TWIST1 ELISA Kits), and FGFR3 (zeige FGFR3 ELISA Kits) mutations were identified in children with tracheal cartilaginous sleeve (TCS). All five children with a W290C mutation in FGFR2 had TCS, and most previously reported children with W290C had identification of TCS or early death
a novel identical postzygotic activating FGFR2 mutation in two unrelated fetuses with papillomatous pedunculated sebaceous naevus.
Testis determination involves FGFR2c-mediated repression of both the WNT4 (zeige WNT4 ELISA Kits)- and FOXL2 (zeige FOXL2 ELISA Kits)-driven ovarian-determining pathways.
the localization of FGF9 and its receptors at different embryonic and postnatal stages in mice testes, was examined.
FGFR2 signalling correlates with maintenance of expression of a key transcription factor for basal cell self-renewal and differentiation: SOX2 (zeige SOX2 ELISA Kits).
Fgfr2 is seen within submucosal glandular epithelial cells. The medial nasal glands were missing in Fgfr2b mutants.
It is well accepted that myelin is a biologically active membrane in active communication with the axons. However, the axonal signals, the receptors on myelin, and the integration of intracellular signaling pathways emanating downstream from these receptors that drive the growth of the myelin sheath remain poorly understood in the CNS. This study brings up the intriguing possibility that FGF receptor 2, in the oligodendr
data suggest that FGF2 (zeige FGF2 ELISA Kits) levels are critically related to anxiety behavior and hypothalamic pituitary- adrenal axis activity, likely through modulation of hippocampal glucocorticoid receptor (zeige NR3C1 ELISA Kits) expression, an effect that is likely receptor mediated, albeit not by FGFR1 (zeige FGFR1 ELISA Kits), FGFR2, and FGFR3 (zeige FGFR3 ELISA Kits).
Results show that Fgfr2 regulates both the formation and resolution of tetrads and rosettes in the mouse embryo, possibly in part by spatially restricting atypical protein kinase C (zeige PRKCZ ELISA Kits), a negative regulator of non-muscle myosin IIB (zeige MYH10 ELISA Kits).
FGFR2c signaling regulates branching morphogenesis through the activation of FGFR2b signaling via increased FGF10 (zeige FGF10 ELISA Kits) autocrine. These results provide new insight into the mechanisms by which crosstalk between FGFR2b and FGFR2c results in efficient branching morphogenesis.
Fgfr2 is critical for bladder mesenchyme patterning by virtue of its role in modulation of hedgehog (zeige SHH ELISA Kits) signaling
Ectopic expression of Fgfr2c was detected within the affected sutures of Bcl11b (zeige BCL11B ELISA Kits)(-/-) mice. Ectopic expression of Fgfr2c in the sutural mesenchyme, without concomitant changes in the expression of FGF ligands, appears to induce the RUNX2 (zeige RUNX2 ELISA Kits)-dependent osteogenic program and craniosynostosis in Bcl11b (zeige BCL11B ELISA Kits)(-/-) mice.
mRNA and protein expression of FGFR-1 (zeige FGFR1 ELISA Kits), FGFR-2 in the porcine umbilical cord during pregnancy.
EGFR (zeige EGFR ELISA Kits), VEGFR (zeige KDR ELISA Kits) and FGFR are expressed in porcine oviduct and endometrium during the time of implantation [review]
analysis of regulation of endometrial fibroblast growth factor 7 (FGF-7 (zeige FGF7 ELISA Kits)) and its receptor FGFR2IIIb
FGFR2 signaling appears to be associated with the regulation of inner cell mass development and proliferation during blastocyst formation in cattle.
activation of FGFR1 (zeige FGFR1 ELISA Kits) and FGFR2 by uterine- and endometrial-derived FGF2 (zeige FGF2 ELISA Kits) stimulates PI3K/AKT (zeige AKT1 ELISA Kits) and mitogen-activated protein kinase (zeige MAPK1 ELISA Kits) pathways for development of the porcine uterus and improvement of litter size
it is highly likely that the missense mutation in the FGFR2 gene caused the bovine facial dysplasia syndrome phenotype in a dominant mode of inheritance.
FGF10 (zeige FGF10 ELISA Kits) and its receptor FGFR2b are more expressed in subordinate follicles; FGF10 (zeige FGF10 ELISA Kits) acts as an important regulator of follicular growth in cattle.
Alterations in the expression of VEGF-A (zeige VEGFA ELISA Kits) and bFGF (zeige FGF2 ELISA Kits) systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.
These data support a role for FGF10 (zeige FGF10 ELISA Kits) and fibroblast growth factor receptor 2B in signaling to granulosa cells from theca cells and/or the oocyte.(fibroblast growth factor receptor 2B)
FGF10 (zeige FGF10 ELISA Kits) mRNA expression did not change during functional luteolysis, whereas FGFR2B mRNA abundance decreased significantly at 2, 4, and 12 hr after PGF2alpha, and returned to pretreatment levels for the period 24-64 hr post-PGF2alpha
we show that minimal amounts of Fgfr1a or Fgfr2 are required to initiate a regulatory cascade in pharyngeal endoderm reducing expression of fsta, thereby allowing correct BMP signaling to the maturing chondrocytes of the head cartilage.
the roles of Fgfr2 signaling in zebrafish left-right asymmetry
The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
fibroblast growth factor receptor 2
, bacteria-expressed kinase
, keratinocyte growth factor receptor
, fibroblast growth factor receptor 2 IIIb
, fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome)
, BEK fibroblast growth factor receptor
, FGF receptor
, hydroxyaryl-protein kinase
, protein tyrosine kinase, receptor like 14
, soluble FGFR4 variant 4
, FGF-7 receptor 2IIIb
, fgf receptor
, chicken tyrosine kinase (cek3)
, receptor tyrosine kinase
, tyrosine kinase receptor CEK3
, fibroblast growth factor receptor-2