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Human Monoclonal FGFR2 Primary Antibody für IHC (p), ELISA - ABIN560876
Ozawa, Yang, Ealy: The expression of fibroblast growth factor receptors during early bovine conceptus development and pharmacological analysis of their actions on trophoblast growth in vitro. in Reproduction (Cambridge, England) 2013
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Human Polyclonal FGFR2 Primary Antibody für FACS, IF - ABIN391965
Freeman, Gangula, Welm, Ozen, Foster, Rosen, Ittmann, Greenberg, Spencer et al.: Conditional activation of fibroblast growth factor receptor (FGFR) 1, but not FGFR2, in prostate cancer cells leads to increased osteopontin induction, extracellular signal-regulated kinase ... in Cancer research 2003
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Human Monoclonal FGFR2 Primary Antibody für CyTOF, FACS - ABIN4900757
Rossi, Jeker, Ueno, Kuse, Keller, Zuklys, Gudkov, Takahama, Krenger, Blazar, Holländer: Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells. in Blood 2007
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Cow (Bovine) Polyclonal FGFR2 Primary Antibody für WB - ABIN611352
Steegmaier, Yang, Yoo, Huang, Shen, Yu, Luo, Scheller: Three novel proteins of the syntaxin/SNAP-25 family. in The Journal of biological chemistry 1999
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Human Polyclonal FGFR2 Primary Antibody für ELISA, WB - ABIN314240
McGrath, Lee, Buring, Hunter, De Vivo: Novel breast cancer risk alleles and endometrial cancer risk. in International journal of cancer 2008
Human Polyclonal FGFR2 Primary Antibody für IHC, IHC (p) - ABIN4311537
Tchaicha, Akbay, Altabef, Mikse, Kikuchi, Rhee, Liao, Bronson, Sholl, Meyerson, Hammerman, Wong: Kinase domain activation of FGFR2 yields high-grade lung adenocarcinoma sensitive to a Pan-FGFR inhibitor in a mouse model of NSCLC. in Cancer research 2014
Human Monoclonal FGFR2 Primary Antibody für CyTOF, FACS - ABIN4900756
Ponte, Marais, Gallay, Langonné, Delorme, Hérault, Charbord, Domenech: The in vitro migration capacity of human bone marrow mesenchymal stem cells: comparison of chemokine and growth factor chemotactic activities. in Stem cells (Dayton, Ohio) 2007
Data suggest that the SOX9 transcription factor (SOX9 (zeige SOX9 Antikörper))-fibroblast growth factor receptor 2 (FGFR2b) feed-forward loop has a lineage dependency role in pancreatic ductal adenocarcinoma (PDAC).
Studies indicate that switching from fibroblast growth factor receptor 2 (FDFR-2) IIIb to IIIc variants correlates with the aggressiveness of the cancers via epithelial-mesenchymal transition [Review].
These results unveil the complexity of ER regulation by FGFR2-mediated signaling likely to be associated with BCa (zeige BLNK Antikörper) resistance to endocrine therapy.
Study report that 5-10% of epidermal nevi harbor embryonic postzygotic FGFR2 activating mutations.
this study identified an FGFR2 in two Chinese patients with syndromic craniosynostosis. The finding expands the reported mutation spectrum of FGFR2, and is of great value for genetic counseling and prenatal diagnosis in families with syndromic craniosynostosis.
Through a stratification analysis, 5q11.2/MAP3K1 (zeige MAP3K1 Antikörper) (rs16886034, rs16886364, rs16886397, rs1017226, rs16886448) and 7q32.3/LINC-PINT (rs4593472) were associated with Luminal A, and 10q26.1/FGFR2 (rs35054928) was associated with Luminal B.
SNORD126 activates the PI3K (zeige PIK3CA Antikörper)-AKT (zeige AKT1 Antikörper) pathway by upregulation of FGFR2.
This study reveals a direct binding event and characterizes the role of TRPA1 (zeige TRPA1 Antikörper) ankyrin (zeige ANK Antikörper) repeats in regulating FGFR2-driven oncogenic process; a mechanism that is hindered by miRNA-142-3p
Although FGFR2 amplification is associated with poorer OS, it does not appear to be an independent prognostic predictor in patients with advanced gastric cancer treated with palliative fluoropyrimidine and platinum chemotherapy.
This meta-analysis of case-control studies provides strong evidence that FGFR2 (rs2981582, rs2420946 and rs2981578) polymorphisms were significantly associated with the BC risk.
gain-of-function mutation in FGFR2 exerts a Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper)-dependent anabolic effect on trabecular bone by promoting bone formation.
small interfering RNA knockdown of FGFR2 suppressed PI3K/Akt (zeige AKT1 Antikörper) pathway activation by FGF10 (zeige FGF10 Antikörper) and abolished its anti-apoptotic and neurite repair effects in vitro.
Testis determination involves FGFR2c-mediated repression of both the WNT4 (zeige WNT4 Antikörper)- and FOXL2 (zeige FOXL2 Antikörper)-driven ovarian-determining pathways.
the localization of FGF9 and its receptors at different embryonic and postnatal stages in mice testes, was examined.
FGFR2 signalling correlates with maintenance of expression of a key transcription factor for basal cell self-renewal and differentiation: SOX2 (zeige SOX2 Antikörper).
Fgfr2 is seen within submucosal glandular epithelial cells. The medial nasal glands were missing in Fgfr2b mutants.
It is well accepted that myelin is a biologically active membrane in active communication with the axons. However, the axonal signals, the receptors on myelin, and the integration of intracellular signaling pathways emanating downstream from these receptors that drive the growth of the myelin sheath remain poorly understood in the CNS. This study brings up the intriguing possibility that FGF receptor 2, in the oligodendr
data suggest that FGF2 (zeige FGF2 Antikörper) levels are critically related to anxiety behavior and hypothalamic pituitary- adrenal axis activity, likely through modulation of hippocampal glucocorticoid receptor (zeige NR3C1 Antikörper) expression, an effect that is likely receptor mediated, albeit not by FGFR1 (zeige FGFR1 Antikörper), FGFR2, and FGFR3 (zeige FGFR3 Antikörper).
Results show that Fgfr2 regulates both the formation and resolution of tetrads and rosettes in the mouse embryo, possibly in part by spatially restricting atypical protein kinase C (zeige PRKCZ Antikörper), a negative regulator of non-muscle myosin IIB (zeige MYH10 Antikörper).
FGFR2c signaling regulates branching morphogenesis through the activation of FGFR2b signaling via increased FGF10 (zeige FGF10 Antikörper) autocrine. These results provide new insight into the mechanisms by which crosstalk between FGFR2b and FGFR2c results in efficient branching morphogenesis.
mRNA and protein expression of FGFR-1 (zeige FGFR1 Antikörper), FGFR-2 in the porcine umbilical cord during pregnancy.
EGFR (zeige EGFR Antikörper), VEGFR (zeige KDR Antikörper) and FGFR are expressed in porcine oviduct and endometrium during the time of implantation [review]
analysis of regulation of endometrial fibroblast growth factor 7 (FGF-7 (zeige FGF7 Antikörper)) and its receptor FGFR2IIIb
FGFR2 signaling appears to be associated with the regulation of inner cell mass development and proliferation during blastocyst formation in cattle.
activation of FGFR1 (zeige FGFR1 Antikörper) and FGFR2 by uterine- and endometrial-derived FGF2 (zeige FGF2 Antikörper) stimulates PI3K/AKT (zeige AKT1 Antikörper) and mitogen-activated protein kinase (zeige MAPK1 Antikörper) pathways for development of the porcine uterus and improvement of litter size
it is highly likely that the missense mutation in the FGFR2 gene caused the bovine facial dysplasia syndrome phenotype in a dominant mode of inheritance.
FGF10 (zeige FGF10 Antikörper) and its receptor FGFR2b are more expressed in subordinate follicles; FGF10 (zeige FGF10 Antikörper) acts as an important regulator of follicular growth in cattle.
Alterations in the expression of VEGF-A (zeige VEGFA Antikörper) and bFGF (zeige FGF2 Antikörper) systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.
These data support a role for FGF10 (zeige FGF10 Antikörper) and fibroblast growth factor receptor 2B in signaling to granulosa cells from theca cells and/or the oocyte.(fibroblast growth factor receptor 2B)
FGF10 (zeige FGF10 Antikörper) mRNA expression did not change during functional luteolysis, whereas FGFR2B mRNA abundance decreased significantly at 2, 4, and 12 hr after PGF2alpha, and returned to pretreatment levels for the period 24-64 hr post-PGF2alpha
we show that minimal amounts of Fgfr1a or Fgfr2 are required to initiate a regulatory cascade in pharyngeal endoderm reducing expression of fsta, thereby allowing correct BMP signaling to the maturing chondrocytes of the head cartilage.
the roles of Fgfr2 signaling in zebrafish left-right asymmetry
The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
fibroblast growth factor receptor 2
, bacteria-expressed kinase
, keratinocyte growth factor receptor
, fibroblast growth factor receptor 2 IIIb
, fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome)
, BEK fibroblast growth factor receptor
, FGF receptor
, hydroxyaryl-protein kinase
, protein tyrosine kinase, receptor like 14
, soluble FGFR4 variant 4
, FGF-7 receptor 2IIIb
, fgf receptor
, chicken tyrosine kinase (cek3)
, receptor tyrosine kinase
, tyrosine kinase receptor CEK3
, fibroblast growth factor receptor-2