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anti-Human FGFR1 Antikörper:
anti-Mouse (Murine) FGFR1 Antikörper:
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Human Polyclonal FGFR1 Primary Antibody für FACS, IF - ABIN1882081
Jiao, Greendorfer, Zhang, Zinn, Diglio, Thompson: Alternatively spliced FGFR-1 isoform signaling differentially modulates endothelial cell responses to peroxynitrite. in Archives of biochemistry and biophysics 2003
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Human Monoclonal FGFR1 Primary Antibody für ELISA, WB - ABIN969138
Hu, Fang, Dunham, Prada, Stachowiak, Stachowiak: 90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in FGFR1 signaling. in The Journal of biological chemistry 2004
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Human Monoclonal FGFR1 Primary Antibody für CyTOF, FACS - ABIN268017
Zhao, Frist, Yeoh, Miller: Modification of alternative messenger RNA splicing of fibroblast growth factor receptors in human cardiac allografts during rejection. in The Journal of clinical investigation 1994
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Human Monoclonal FGFR1 Primary Antibody für CyTOF, FACS - ABIN269474
Sasaki, Ishida, Toyota, Ota, Suzuki, Takaoka, Yasui, Yamamoto, Takagi, Maeda, Seito, Tsujisaki, Shinomura, Imai: Interferon-α/β and anti-fibroblast growth factor receptor 1 monoclonal antibody suppress hepatic cancer cells in vitro and in vivo. in PLoS ONE 2011
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Human Polyclonal FGFR1 Primary Antibody für IHC (p), WB - ABIN3044410
Zhang, Zhang, Zhuang, Lu: Cytotoxicity of a novel fibroblast growth factor receptor targeted immunotoxin on a human ovarian teratocarcinoma cell line. in Cancer biotherapy & radiopharmaceuticals 2006
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Human Monoclonal FGFR1 Primary Antibody für ELISA, WB - ABIN966139
Magnusson, Ronca, DellEra, Carlstedt, Jakobsson, Partanen, Dimberg, Claesson-Welsh: Fibroblast growth factor receptor-1 expression is required for hematopoietic but not endothelial cell development. in Arteriosclerosis, thrombosis, and vascular biology 2005
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Human Monoclonal FGFR1 Primary Antibody für CyTOF, FACS - ABIN250616
Wang, Kan, McKeehan, Jang, Feng, McKeehan: A homeo-interaction sequence in the ectodomain of the fibroblast growth factor receptor. in The Journal of biological chemistry 1997
Human Polyclonal FGFR1 Primary Antibody für IHC (p), IHC - ABIN250368
Torry, Mukherjea, Arroyo, Torry: Expression and function of placenta growth factor: implications for abnormal placentation. in Journal of the Society for Gynecologic Investigation 2003
Human Monoclonal FGFR1 Primary Antibody für CyTOF, FACS - ABIN250617
Robinson, MacMillan-Crow, Thompson, Overbeek: Expression of a truncated FGF receptor results in defective lens development in transgenic mice. in Development (Cambridge, England) 1996
Human Polyclonal FGFR1 Primary Antibody für ELISA, WB - ABIN4311479
Weiss, Sos, Seidel, Peifer, Zander, Heuckmann, Ullrich, Menon, Maier, Soltermann, Moch, Wagener, Fischer, Heynck, Koker, Schöttle, Leenders, Gabler, Dabow, Querings, Heukamp, Balke-Want, Ansén, Rauh et al.: Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer. ... in Science translational medicine 2010
These results suggest that bFGF (zeige FGF2 Antikörper) activation of neuronal FGFR1 generates filopodial processes in neurons that promote nerve-muscle interaction and facilitate NMJ establishment.
in FGFR1 signalling JNK1 (zeige MAPK8 Antikörper) phosphorylation depends on ERK2 (zeige MAPK1 Antikörper)
Mactosylceramide, an early product in GSL (zeige CTSA Antikörper) biosynthesis, prevents inappropriate activation of insulin (zeige INS Antikörper) and fibroblast growth factor receptors in Drosophila glial cells and hypertrophy.
identify two transcriptional regulators that function downstream of Heartless signaling in lymph gland progenitors, the ETS protein, Pointed, and the Friend-of-GATA protein, U-shaped, which are required for this Heartless-induced differentiation response
We show that salivary gland posterior migration requires the activities of genes that position the visceral mesoderm precursors, such as heartless, thickveins, and tinman (zeige MSH2 Antikörper), but does not require a differentiated visceral mesoderm.
the signal provided by the CAMs acts via the Heartless fibroblast growth factor receptor (FGFR) as outgrowth is reduced to basal levels in the presence of an FGFR (zeige FGFR2 Antikörper) inhibitor or if Heartless function is missing from the neurons.
Study finds infrequent BRAF (zeige BRAF Antikörper) alterations but enriched FGFR (zeige FGFR2 Antikörper) alterations in adults as compared with that reported in pediatric pilocytic astrocytomas. In addition, coexistent BRAF (zeige BRAF Antikörper) and FGFR (zeige FGFR2 Antikörper) alterations and a significant association of FGFR (zeige FGFR2 Antikörper) alterations with age and tumor location were noted.
SNP rs17182023 was correlated to reduced breast cancer risk, and was associated with FGFR1 protein expression. High FGFR1 protein expression was an independent risk factor of breast cancer, and resulted in poor prognosis.
Besides RET (zeige RET Antikörper) and HRAS (zeige HRAS Antikörper), FGFR1 is only the third protooncogene found to be recurrently mutated in pheochromocytomas.
For the treatment of patients with breast cancer and FGFR1 amplifications.
presentation of the atomic structure of a 1:1:1 ternary complex that consists of the shed extracellular domain of alpha-klotho (zeige KL Antikörper), the FGFR1c ligand-binding domain, and FGF23 (zeige FGF23 Antikörper); in this complex, alpha-klotho (zeige KL Antikörper) simultaneously tethers FGFR1c by its D3 domain and FGF23 (zeige FGF23 Antikörper) by its C-terminal tail, thus implementing FGF23 (zeige FGF23 Antikörper)-FGFR1c proximity and conferring stability
Study identified FGFR1, a promoter of glycolysis-related enzyme, as the target of miR (zeige MLXIP Antikörper)-361 that promoted glycolysis and repressed oxidative phosphorylation in breast cancer cells. FGFR1 mediated the anti-glycolytic function of miR (zeige MLXIP Antikörper)-361 by regulating the activity of PDHK1 and LDHA (zeige LDHA Antikörper).
FGFR1 and/or FGF3 (zeige FGF3 Antikörper) gene amplification correlated with a lower pathologic complete response in patients with HER2 (zeige ERBB2 Antikörper)(+) early breast cancer treated with neoadjuvant anti-HER2 (zeige ERBB2 Antikörper) therapy.
Data demonstrated that FOXC1 (zeige FOXC1 Antikörper) binds to an Fgfr1 upstream regulatory region and that FOXC1 (zeige FOXC1 Antikörper) activates an Fgfr1 promoter element. Furthermore, elevated expression of Foxc1 (zeige FOXC1 Antikörper) led to increased Fgfr1-IIIc transcript promoting invasion after TGFbeta1 (zeige TGFB1 Antikörper)-induced EMT (zeige ITK Antikörper).
These results suggest that FGFR1 gene amplification is a frequent alteration in squamous cell carcinoma of the lung and appears not to be a negative but rather a favorable prognostic marker for women and particularly for patients with advanced disease
These data suggest the ERalpha (zeige ESR1 Antikörper) pathway remains active in estrogen-deprived ER(+)/FGFR1-amplified breast cancers. Therefore, these tumors are endocrine resistant and should be candidates for treatment with combinations of ER and FGFR (zeige FGFR2 Antikörper) antagonists.
Oligodendroglial FGFR1 deficient mice (-/-) showed a significantly ameliorated disease course in MOG35-55 -induced experimental autoimmune encephalomyelitis. Less myelin and axonal loss, and reduced lymphocyte and macrophage/microglia infiltration were found in Fgfr1(-/-) mice. Reduction in disease severity in Fgfr1(ind-/-) mice was accompanied by ERK (zeige EPHB2 Antikörper)/AKT (zeige AKT1 Antikörper) phosphorylation, and increased expression of BDNF (zeige BDNF Antikörper) and TrkB (zeige NTRK2 Antikörper).
Suboptimal FGFR (zeige FGFR2 Antikörper) activation by a weak FGF1 (zeige FGF1 Antikörper)-FGFR (zeige FGFR2 Antikörper) dimer is sufficient to evoke a metabolic response, whereas full FGFR (zeige FGFR2 Antikörper) activation by stable and sustained dimerization is required to elicit a mitogenic response.
the close proximity between AcSDKP and FGFR1 was essential for the suppression of TGFbeta (zeige TGFB1 Antikörper)/smad (zeige SMAD1 Antikörper) signaling and EndMT associated with MAP4K4 (zeige MAP4K4 Antikörper) phosphorylation (P-MAP4K4 (zeige MAP4K4 Antikörper)) in endothelial cells.
FGFR1 is a driver oncogene (zeige RAB1A Antikörper) in de novo, FGFR1-overexpressing acute myeloid leukemia (zeige BCL11A Antikörper)
Visceral adipose tissue-derived factors stimulate cell transformation through FGFR-1.
the localization of FGF9 and its receptors at different embryonic and postnatal stages in mice testes, was examined.
CDC42 (zeige CDC42 Antikörper) is involved in the trafficking of FGF receptors to the cell membrane to regulate epicardium formation.
MAPK (zeige MAPK1 Antikörper) cascades participate in osteogenesis, but only the ERK (zeige EPHB2 Antikörper) signaling pathway responds to FGFR1.
It is well accepted that myelin is a biologically active membrane in active communication with the axons. However, the axonal signals, the receptors on myelin, and the integration of intracellular signaling pathways emanating downstream from these receptors that drive the growth of the myelin sheath remain poorly understood in the CNS. This study brings up the intriguing possibility that FGF receptor (zeige FGFR2 Antikörper) 2, in the oligodendr
data suggest that FGF2 (zeige FGF2 Antikörper) levels are critically related to anxiety behavior and hypothalamic pituitary- adrenal axis activity, likely through modulation of hippocampal glucocorticoid receptor (zeige NR3C1 Antikörper) expression, an effect that is likely receptor mediated, albeit not by FGFR1, FGFR2 (zeige FGFR2 Antikörper), and FGFR3 (zeige FGFR3 Antikörper).
activation of FGFR1 and FGFR2 (zeige FGFR2 Antikörper) by uterine- and endometrial-derived FGF2 (zeige FGF2 Antikörper) stimulates PI3K/AKT (zeige AKT1 Antikörper) and mitogen-activated protein kinase (zeige MAPK1 Antikörper) pathways for development of the porcine uterus and improvement of litter size
Alterations in the expression of VEGF-A (zeige VEGFA Antikörper) and bFGF (zeige FGF2 Antikörper) systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.
mRNA and protein expression of FGFR-1, FGFR-2 (zeige FGFR2 Antikörper) in the porcine umbilical cord during pregnancy.
Here we demonstrate that of the nine FGFR1 mutations recently detected in our screen of over 200 HPE probands by next generation sequencing, only five distinct mutations in the kinase domain behave as dominant-negative mutations in zebrafish over-expression assays
we show that minimal amounts of Fgfr1a or Fgfr2 are required to initiate a regulatory cascade in pharyngeal endoderm reducing expression of fsta, thereby allowing correct BMP signaling to the maturing chondrocytes of the head cartilage.
Data indicate that fgf20a, fgf24, FGF receptor (zeige FGFR2 Antikörper) fgfr1 are expressed in normal and regenerating barbel tissue.
Shroom3 (zeige SHROOM3 Antikörper) is required downstream of FGF signalling to mediate proneuromast assembly in zebrafish.
fgfr (zeige FGFR2 Antikörper) expression is directly or indirectly regulated by FGF signaling during epiboly and at the end of somitogenesis.
we describe cloning and expression analysis of the zebrafish fibroblast growth factor receptor 1 ( fgfr1).
knock-down of Fgfr1, but not muscle segment homeobox B, affected the blastemal expression of msxc, suggesting this technique can be used to determine epistasis in genetic pathways affecting regeneration
Bmp and Fgf signaling are essential for liver specification in zebrafish.
The analysis of receptor-ligand interactions between D. rerio fgf8 (zeige FGF8 Antikörper) and its receptors, fgfr1 and fgfr4 (zeige FGFR4 Antikörper), using combined spectroscopy methods are reported.
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described\; however, not all variants have been fully characterized.
fibroblast growth factor receptor
, fibroblast growth factor receptor-1
, basic fibroblast growth factor receptor 1
, FGF receptor
, fibroblast growth factor receptor 1
, fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)
, ibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)
, basic fibroblast growth factor receptor 1-like
, FGFR1/PLAG1 fusion
, FMS-like tyrosine kinase 2
, fms-related tyrosine kinase 2
, heparin-binding growth factor receptor
, hydroxyaryl-protein kinase
, proto-oncogene c-Fgr
, FGF receptor-1
, cek1 protein
, tyrosine kinase receptor CEK1
, basic fibroblast growth factor receptor 1-A
, fibroblast growth factor receptor 1-A