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anti-Human FGFR1 Antikörper:
anti-Mouse (Murine) FGFR1 Antikörper:
anti-Rat (Rattus) FGFR1 Antikörper:
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Human Polyclonal FGFR1 Primary Antibody für FACS, IF - ABIN1882081
Jiao, Greendorfer, Zhang, Zinn, Diglio, Thompson: Alternatively spliced FGFR-1 isoform signaling differentially modulates endothelial cell responses to peroxynitrite. in Archives of biochemistry and biophysics 2003
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Human Monoclonal FGFR1 Primary Antibody für ELISA, WB - ABIN969138
Hu, Fang, Dunham, Prada, Stachowiak, Stachowiak: 90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in FGFR1 signaling. in The Journal of biological chemistry 2004
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Human Monoclonal FGFR1 Primary Antibody für CyTOF, FACS - ABIN269474
Sasaki, Ishida, Toyota, Ota, Suzuki, Takaoka, Yasui, Yamamoto, Takagi, Maeda, Seito, Tsujisaki, Shinomura, Imai: Interferon-α/β and anti-fibroblast growth factor receptor 1 monoclonal antibody suppress hepatic cancer cells in vitro and in vivo. in PLoS ONE 2011
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Human Monoclonal FGFR1 Primary Antibody für CyTOF, FACS - ABIN268017
Zhao, Frist, Yeoh, Miller: Modification of alternative messenger RNA splicing of fibroblast growth factor receptors in human cardiac allografts during rejection. in The Journal of clinical investigation 1994
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Human Monoclonal FGFR1 Primary Antibody für ELISA, WB - ABIN966139
Magnusson, Ronca, DellEra, Carlstedt, Jakobsson, Partanen, Dimberg, Claesson-Welsh: Fibroblast growth factor receptor-1 expression is required for hematopoietic but not endothelial cell development. in Arteriosclerosis, thrombosis, and vascular biology 2005
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Human Polyclonal FGFR1 Primary Antibody für IHC (p), WB - ABIN3044410
Zhang, Zhang, Zhuang, Lu: Cytotoxicity of a novel fibroblast growth factor receptor targeted immunotoxin on a human ovarian teratocarcinoma cell line. in Cancer biotherapy & radiopharmaceuticals 2006
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Human Monoclonal FGFR1 Primary Antibody für CyTOF, FACS - ABIN250617
Robinson, MacMillan-Crow, Thompson, Overbeek: Expression of a truncated FGF receptor results in defective lens development in transgenic mice. in Development (Cambridge, England) 1996
Human Polyclonal FGFR1 Primary Antibody für IHC (p), IHC - ABIN250368
Torry, Mukherjea, Arroyo, Torry: Expression and function of placenta growth factor: implications for abnormal placentation. in Journal of the Society for Gynecologic Investigation 2003
Human Monoclonal FGFR1 Primary Antibody für CyTOF, FACS - ABIN250616
Wang, Kan, McKeehan, Jang, Feng, McKeehan: A homeo-interaction sequence in the ectodomain of the fibroblast growth factor receptor. in The Journal of biological chemistry 1997
Cow (Bovine) Polyclonal FGFR1 Primary Antibody für IHC (p), WB - ABIN4311478
Feng, Shao, Castro, Coleman, Nelson, Smith, Davies, Ittmann: Combination treatment of prostate cancer with FGF receptor and AKT kinase inhibitors. in Oncotarget 2016
These results suggest that bFGF (zeige FGF2 Antikörper) activation of neuronal FGFR1 generates filopodial processes in neurons that promote nerve-muscle interaction and facilitate NMJ establishment.
in FGFR1 signalling JNK1 (zeige MAPK8 Antikörper) phosphorylation depends on ERK2 (zeige MAPK1 Antikörper)
Mactosylceramide, an early product in GSL (zeige CTSA Antikörper) biosynthesis, prevents inappropriate activation of insulin (zeige INS Antikörper) and fibroblast growth factor receptors in Drosophila glial cells and hypertrophy.
identify two transcriptional regulators that function downstream of Heartless signaling in lymph gland progenitors, the ETS protein, Pointed, and the Friend-of-GATA protein, U-shaped, which are required for this Heartless-induced differentiation response
We show that salivary gland posterior migration requires the activities of genes that position the visceral mesoderm precursors, such as heartless, thickveins, and tinman (zeige MSH2 Antikörper), but does not require a differentiated visceral mesoderm.
the signal provided by the CAMs acts via the Heartless fibroblast growth factor receptor (FGFR) as outgrowth is reduced to basal levels in the presence of an FGFR (zeige FGFR2 Antikörper) inhibitor or if Heartless function is missing from the neurons.
Fibrolamellar carcinomas show polysomy of chromosome 8 and the FGFR1 locus, and only modest mRNA expression and weak or absent expression at the protein level. FGFR2 (zeige FGFR2 Antikörper) rearrangement was not detected.
endothelin-A receptor (zeige EDNRA Antikörper)-activated ABCB1 (zeige ABCB1 Antikörper) expression has a role in nintedanib resistance in FGFR1-driven small cell lung cancer
Loss of FGFR1 does generate a gene signature that is reverse correlated with FGFR1 gene amplification and/or upregulation in human breast cancer. Our results suggest that FGFR1 signaling is a key pathway driving breast cancer lung metastasis and that targeting FGFR1 in breast cancer is an exciting approach to inhibit metastasis.
Combination treatment with AKT (zeige AKT1 Antikörper) and FGFR (zeige FGFR2 Antikörper) kinase inhibitors have additive effects on malignant phenotypes in vitro and in vivo by inhibiting multiple signaling pathways and mitigating the compensatory upregulation of FGFR (zeige FGFR2 Antikörper) signaling induced by AKT (zeige AKT1 Antikörper) kinase inhibition.
FGFR1/MAPK (zeige MAPK1 Antikörper) may be important for brachyury (zeige TBX1 Antikörper) activation in lung cancer, and this pathway may be an appealing therapeutic target for a subset of brachyury (zeige TBX1 Antikörper)-driven lung cancer.
FGFR1 alteration mainly represented by FGFR1-ITD is a frequent event in dysembryoplastic neuroepithelial tumors. Digital droplet PCRtrade mark is an easy and alternative method than whole-genome sequencing to detect FGFR1-ITD in Formalin-fixed paraffin-embedded brain tumors, in routine practice.
Report dramatic upregulation of fibroblast growth factor receptor 1 (FGFR1) and its cognate ligand FGF2 (zeige FGF2 Antikörper) in both acquired and inherently resistant breast cancer cells.
This study reveals a stringent association between FGFR (zeige FGFR2 Antikörper) and the downstream effector c-Myc (zeige MYC Antikörper) in FGFR (zeige FGFR2 Antikörper)-dependent cancers, and suggests the potential therapeutic value of c-Myc (zeige MYC Antikörper) in FGFR (zeige FGFR2 Antikörper)-targeted cancer therapy.
Elevated FGFR3 (zeige FGFR3 Antikörper) and FGFR1 protein expression is common in aggressive ependymomas but likely not driven by genetic alterations. Further studies are warranted to evaluate whether ependymoma patients with high FGFR3 (zeige FGFR3 Antikörper) and/or FGFR1 expression could benefit from treatment with FGFR (zeige FGFR2 Antikörper) inhibitor based therapeutic approaches currently under evaluation in clinical trials
These data identify FGFR1 as a driver gene in multiple soft-tissue sarcoma subtypes and support FGFR1 inhibition, guided by patient selection according to the FGFR1 expression and monitoring of MAPK-ERK1/2 signaling, as a therapeutic option in this challenging group of diseases
FGFR1 is a driver oncogene (zeige RAB1A Antikörper) in de novo, FGFR1-overexpressing acute myeloid leukemia (zeige BCL11A Antikörper)
Visceral adipose tissue-derived factors stimulate cell transformation through FGFR-1.
the localization of FGF9 and its receptors at different embryonic and postnatal stages in mice testes, was examined.
CDC42 (zeige CDC42 Antikörper) is involved in the trafficking of FGF receptors to the cell membrane to regulate epicardium formation.
MAPK (zeige MAPK1 Antikörper) cascades participate in osteogenesis, but only the ERK (zeige EPHB2 Antikörper) signaling pathway responds to FGFR1.
It is well accepted that myelin is a biologically active membrane in active communication with the axons. However, the axonal signals, the receptors on myelin, and the integration of intracellular signaling pathways emanating downstream from these receptors that drive the growth of the myelin sheath remain poorly understood in the CNS. This study brings up the intriguing possibility that FGF receptor (zeige FGFR2 Antikörper) 2, in the oligodendr
data suggest that FGF2 (zeige FGF2 Antikörper) levels are critically related to anxiety behavior and hypothalamic pituitary- adrenal axis activity, likely through modulation of hippocampal glucocorticoid receptor (zeige NR3C1 Antikörper) expression, an effect that is likely receptor mediated, albeit not by FGFR1, FGFR2 (zeige FGFR2 Antikörper), and FGFR3 (zeige FGFR3 Antikörper).
clearly demonstrate the different specificity of FGF12 (zeige FGF12 Antikörper)-FGFR1c2 and FGF22 (zeige FGF22 Antikörper)-FGFR1c2 for well defined HS structures and suggest that it is now possible to chemoenzymatically synthesize precise HS polysaccharides that can selectively mediate growth factor signaling
The study supports a pro-adipogenic role for betaKlotho (zeige KLB Antikörper) in skeletal muscle fibro/adipogenesis and calls for further research on involvement of the FGF-FGFR (zeige FGFR2 Antikörper)-betaKlotho (zeige KLB Antikörper) axis in the fibro/adipogenic infiltration associated with functional deterioration of skeletal muscle in aging and muscular dystrophy.
These new findings reveal that the FGF21-betaKlotho-FGFR1 signaling axis plays roles in maintaining phospholipid homeostasis and the dynamic functions of the lipid droplet, whereas protecting against ER stress, and suggest a potential link of phospholipid biosynthesis, lipid droplet dynamics, ER stress, and energy homeostasis in adipose tissue coordinated by this signaling axis.
activation of FGFR1 and FGFR2 (zeige FGFR2 Antikörper) by uterine- and endometrial-derived FGF2 (zeige FGF2 Antikörper) stimulates PI3K/AKT (zeige AKT1 Antikörper) and mitogen-activated protein kinase (zeige MAPK1 Antikörper) pathways for development of the porcine uterus and improvement of litter size
Alterations in the expression of VEGF-A (zeige VEGFA Antikörper) and bFGF (zeige FGF2 Antikörper) systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.
mRNA and protein expression of FGFR-1, FGFR-2 (zeige FGFR2 Antikörper) in the porcine umbilical cord during pregnancy.
Here we demonstrate that of the nine FGFR1 mutations recently detected in our screen of over 200 HPE probands by next generation sequencing, only five distinct mutations in the kinase domain behave as dominant-negative mutations in zebrafish over-expression assays
we show that minimal amounts of Fgfr1a or Fgfr2 are required to initiate a regulatory cascade in pharyngeal endoderm reducing expression of fsta, thereby allowing correct BMP signaling to the maturing chondrocytes of the head cartilage.
Data indicate that fgf20a, fgf24, FGF receptor (zeige FGFR2 Antikörper) fgfr1 are expressed in normal and regenerating barbel tissue.
Shroom3 (zeige SHROOM3 Antikörper) is required downstream of FGF signalling to mediate proneuromast assembly in zebrafish.
fgfr (zeige FGFR2 Antikörper) expression is directly or indirectly regulated by FGF signaling during epiboly and at the end of somitogenesis.
we describe cloning and expression analysis of the zebrafish fibroblast growth factor receptor 1 ( fgfr1).
knock-down of Fgfr1, but not muscle segment homeobox B, affected the blastemal expression of msxc, suggesting this technique can be used to determine epistasis in genetic pathways affecting regeneration
Bmp and Fgf signaling are essential for liver specification in zebrafish.
The analysis of receptor-ligand interactions between D. rerio fgf8 (zeige FGF8 Antikörper) and its receptors, fgfr1 and fgfr4 (zeige FGFR4 Antikörper), using combined spectroscopy methods are reported.
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described\; however, not all variants have been fully characterized.
fibroblast growth factor receptor
, fibroblast growth factor receptor-1
, basic fibroblast growth factor receptor 1
, FGF receptor
, fibroblast growth factor receptor 1
, fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)
, ibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)
, basic fibroblast growth factor receptor 1-like
, FGFR1/PLAG1 fusion
, FMS-like tyrosine kinase 2
, fms-related tyrosine kinase 2
, heparin-binding growth factor receptor
, hydroxyaryl-protein kinase
, proto-oncogene c-Fgr
, FGF receptor-1
, cek1 protein
, tyrosine kinase receptor CEK1
, basic fibroblast growth factor receptor 1-A
, fibroblast growth factor receptor 1-A