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Human FGF7 Protein expressed in Human - ABIN2452199
Aaronson, Bottaro, Miki, Ron, Finch, Fleming, Ahn, Taylor, Rubin: Keratinocyte growth factor. A fibroblast growth factor family member with unusual target cell specificity. in Annals of the New York Academy of Sciences 1992
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Human FGF7 Protein expressed in Escherichia coli (E. coli) - ABIN2452198
Rubin, Osada, Finch, Taylor, Rudikoff, Aaronson: Purification and characterization of a newly identified growth factor specific for epithelial cells. in Proceedings of the National Academy of Sciences of the United States of America 1989
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The stability and activity of rhKGF mutants were analyzed using GROMACS molecular dynamics (MD) simulations and docking tools, respectively. The results showed that N159S (N105S in rhKGF sequence) and I172V (I118V in rhKGF) substitutions caused an increased stability and affinity of the rhKGF to Fibroblast growth factor receptor 2 (FGFR2 (zeige FGFR2 Proteine)).
Tregs isolated from human lung tissue can be stimulated ex vivo to induce kgf expression.
FGF7 stimulation of cell invasion and migration was partially suppressed by the FGFR2 (zeige FGFR2 Proteine) knockdown. In addition, FGF7/FGFR2 (zeige FGFR2 Proteine) upregulated THBS1 (zeige THBS1 Proteine), and cell invasion and migration were decreased by knockdown of THBS1 (zeige THBS1 Proteine)
Suppression of miR (zeige MLXIP Proteine)-219-5p may benefit the liver regeneration and prevent cirrhosis through increasing KGF.
This study evaluated the expression of FGF7, AhR (zeige AHR Proteine), and CYP1A1 (zeige CYP1A1 Proteine) in colorectal cancer cells and revealed a new mechanism by which KGF promotes cell proliferation through the AhR (zeige AHR Proteine)-cyclin D1 (zeige CCND1 Proteine) pathway in colon cancer cells.
KGF expression induced epithelial cell proliferation, reaching a peak level at day 4 and then decreased later, while in the long-term model, KGF expression in the EAC (zeige CYLD Proteine) led to middle ear cholesteatoma formation
In the current study, conditioned media and chemically defined media with recombinant human keratinocyte growth factor (KGF) could induce hUC (zeige ELAVL3 Proteine)-MSC (zeige MSC Proteine) differentiation into sweat gland-like cells (SGCs).
Coexpression of KGF and MMP-9 (zeige MMP9 Proteine) in gastric cancer could be a useful prognostic factor, and MMP-9 (zeige MMP9 Proteine) might also serve as a novel target for both prognostic prediction and therapeutics.
FGF7 over expression is associated with advanced clinical features in patients with upper tract and bladder urothelial carcinoma
Data indicate the key roles played, on the melanosome transfer in normal skin, by KGF/FGF7 released by dermal fibroblasts and by its receptor KGFR (zeige FGFR2 Proteine)/FGFR2b expressed and activated on the epidermal keratinocytes.
Tregs express kgf. Treg-specific expression of kgf regulates alveolar epithelial proliferation during the resolution phase of acute lung injury and in a model of regenerative alveologenesis in vivo. AT2 (zeige AGTR2 Proteine) cells cocultured with Tregs lacking kgf have decreased rates of proliferation.
A role for endogenous KGF in maintenance of normal pulmonary innate immune function.
BMP4 (zeige BMP4 Proteine) promotes activation of FGF7 and FGF10 (zeige FGF10 Proteine) signaling, leading to an increase in proliferative basal cell population in developing skin.
we examine how the two presynaptic organizers FGF22 (zeige FGF22 Proteine) and FGF7 are transported to the appropriate locations so that they act as synapse-type-specific organizing molecules.
Exendin-4 increased fibroblast growth factor 7 (Fgf7) expression in colonic polyps of Apc (zeige APC Proteine)(Min/+) mice.
Our observations also point towards PI3K acting as a morphogenic switch for FGF7 signalling.
Reverse transcriptase polymerase chain reaction studies showed that three members, Tgfa, Hbegf,and Nrg1 of the EGF family were expressed in the epithelium cultured with FGF7 + LPA as well as in the epithelium freshly isolated from the rudiments.
IL-19 (zeige IL19 Proteine) is important for cutaneous wound healing because it upregulates KGF expression.
FGF7 is downregulated in MED1 (zeige MBD4 Proteine)-deficient mesenchymal cells. FGF7 produced by mesenchymal stromal cells is a novel hematopoietic niche molecule.
Subset of KGF-expressing respiratory epithelial cells may participate in a hitherto undescribed autocrine loop for stimulating KGF production in response to injury.
analysis of regulation of endometrial fibroblast growth factor 7 (FGF-7) and its receptor FGFR2IIIb (zeige FGFR2 Proteine)
This study investigates the relationships between progesterone, estradiol, and their receptors and the expression of FGF7 in the pig uterus in vivo.
FGF1 (zeige FGF1 Proteine) and FGF7 may be involved differently in the process of follicle maturation and CL formation, which is strongly dependent on angiogenesis
FGF7 may be an important regulator for oocyte growth and its action is mediated via the KIT/KITLG (zeige KITLG Proteine) signaling pathway.
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis.
, heparin-binding growth factor 7
, keratinocyte growth factor
, Keratinocyte growth factor
, fibroblast growth factor 7 (keratinocyte growth factor)
, fibroblast growth factor-7
, Putative keratinocyte growth factor-like protein 2
, fibroblast growth factor 7 L homeolog