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anti-Human FGF21 Antikörper:
anti-Mouse (Murine) FGF21 Antikörper:
anti-Rat (Rattus) FGF21 Antikörper:
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Human Polyclonal FGF21 Primary Antibody für IF (p), IHC (p) - ABIN679478
Dong, Yu, Wu, Wang, Niu, Wang, Zou: Echinacoside Induces Apoptosis in Human SW480 Colorectal Cancer Cells by Induction of Oxidative DNA Damages. in International journal of molecular sciences 2015
Taking together from both physiological and genetic levels, we suggest that FGF21 is inversely associated with regional bone density.
besides the NF-kappaB pathway, the mechanism of action of FGF-21 was observed to involve the elevation of IL-10 in the ERK1/2 pathway.
ChREBP and FGF21 constitute a signaling axis likely conserved in humans that mediates (zeige MLXIPL Antikörper)an essential adaptive response to f (zeige MLXIPL Antikörper)ructose ingestion that may participate in the pathogenesis of NAFLD and liver fibrosis.
Excess dietary carbohydrate, but not fat, led to markedly increased FGF21 secretion in humans, notably without protein restriction, and affected glucose and lipid homeostais.
In patients with coronary artery disease at baseline, an elevated serum FGF21 level was associated with development of a major adverse cardiovascular event in the future.
Fibroblast growth factor 21 (FGF21) is an atypical member of the FGF family that functions as an endocrine hormone which regulates carbohydrate and lipid metabolism. It is involved in maintaining of energy homeostasis and adaptation to starvation and low temperature.
FGF21 is a good predictor of acute-on-chronic liver failure and organ failure, is quite specific for cirrhosis, and seems independent of etiology and systemic inflammation.
FGF-21 could regulate the immune response indirectly by influencing the glucose uptake of activated monocytes cells.
FGF21 levels were reduced after energy-restricted treatments and severely increased after bariatric surgery, independently of the weight reduction magnitude, insulin (zeige INS Antikörper) sensitivity or ketosis; therefore, FGF21 appears to be a marker of severe nutritional stress
In HIV-infected individuals, FGF21 is significantly positively associated with liver fat. FGF21 decreases in association with reductions in liver fat, GGT (zeige GGT1 Antikörper), and FIB4, suggesting that FGF21 is upregulated in the context of steatosis and steatohepatitis and is reduced when these conditions improve
The present study shows that expression of the FGF21 gene is strongly up-regulated during the transition period; the up-regulation of FGF21 might play an important role in the adaptation of liver metabolism during early lactation in dairy cows such as in other species.
RESULTS: The results showed that serum FGF-21 levels were significantly higher in both groups treated with a controlled-energy diet, while FGF-21 levels in both groups treated with moderate-energy diet were low.
liver-derived FGF21 regulates the use of lipid reserves during lactation via focal actions on liver and white adipose tissue.
Lack of FGF21 enhances the susceptibility to the development of obesity-related cardiomyopathy.
The acute increase in circulating FGF21 following fructose gavage was absent in ChREBP (zeige MLXIPL Antikörper) knockout mice. Induction of ChREBP (zeige MLXIPL Antikörper)-beta and its glycolytic, fructolytic, and lipogenic gene targets were attenuated in FGF21 knockout mice fed high-fructose diets.
Data, including data from studies using knockout mice, suggest that control of whole-body energy expenditure by Gcgr (zeige GCGR Antikörper) agonism requires intact Fxr (zeige NR1H4 Antikörper) signaling and Fgf21 secretion in liver. (Gcgr (zeige GCGR Antikörper) = glucagon receptor (zeige GCGR Antikörper) glucagon (zeige GCG Antikörper); Fxr (zeige NR1H4 Antikörper) = farnesoid X receptor (zeige xpr1 Antikörper); Fgf21 = fibroblast growth factor-21)
FGF-21 has anti-inflammatory effects in Type 2 diabetes mellitus
These data suggest that Fgf21 acts as one of intrathymic cytokines in the neonatal and juvenile thymus, involving thymocyte development in a beta (zeige SUCLA2 Antikörper)-Klotho (zeige KLB Antikörper)-independent manner.
During pregnancy, both systemic and cardiac-produced Fgf21 act on the heart, leading to the normal physiological cardiac changes that are associated with pregnancy.
our results demonstrated that FGF21 promotes cell cycle exit and enhances myogenic differentiation of C2C12 cells. This study provided new evidence that FGF21 promotes myogenic differentiation, which could be useful for better understanding the roles of FGF21 in myogenesis.
We will clarify the positive and negative signaling mechanisms which control the stress-related expression of FGF21 through the ISR pathway. Moreover, we will examine the role of FGF21 as an interorgan coordinator of survival functions in metabolic and stress disorders. We conclude that FGF21 can be viewed as a cell non-autonomous enhancer of longevity in mammals.
under nutrient-limiting conditions that stimulate ATF4 (zeige ATF4 Antikörper) activity, TRIB3 (zeige TRIB3 Antikörper) is implicated in the regulation of metabolic adaptation by restraining the transcription of Fgf21.
alcohol-induced FGF21 expression is a hepatic adaptive response to lipid dysregulation.
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factor has not yet been determined.
fibroblast growth factor 21