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anti-Human FGF21 Antikörper:
anti-Mouse (Murine) FGF21 Antikörper:
anti-Rat (Rattus) FGF21 Antikörper:
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Human Polyclonal FGF21 Primary Antibody für IF (p), IHC (p) - ABIN679478
Dong, Yu, Wu, Wang, Niu, Wang, Zou: Echinacoside Induces Apoptosis in Human SW480 Colorectal Cancer Cells by Induction of Oxidative DNA Damages. in International journal of molecular sciences 2015
Human Polyclonal FGF21 Primary Antibody für ELISA, WB - ABIN314287
Inagaki, Dutchak, Zhao, Ding, Gautron, Parameswara, Li, Goetz, Mohammadi, Esser, Elmquist, Gerard, Burgess, Hammer, Mangelsdorf, Kliewer: Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. in Cell metabolism 2007
FGF21 levels were reduced after energy-restricted treatments and severely increased after bariatric surgery, independently of the weight reduction magnitude, insulin (zeige INS Antikörper) sensitivity or ketosis; therefore, FGF21 appears to be a marker of severe nutritional stress
In HIV-infected individuals, FGF21 is significantly positively associated with liver fat. FGF21 decreases in association with reductions in liver fat, GGT (zeige GGT1 Antikörper), and FIB4, suggesting that FGF21 is upregulated in the context of steatosis and steatohepatitis and is reduced when these conditions improve
crystal structures of free and ligand-bound beta-klotho (zeige KLB Antikörper) extracellular regions that reveal the molecular mechanism that underlies the specificity of FGF21 towards beta-klotho (zeige KLB Antikörper) and demonstrate how the FGFR (zeige FGFR2 Antikörper) is activated in a klotho (zeige KL Antikörper)-dependent manner
In this review, we will summarize the current progress on the roles of FGF21 against metaflammation and metabolic tissue damage [Review]
This finding suggested FGF21 could be involved in the pathophysiology of diastolic heart failure.
FGF21 plasma levels correlate negatively with protein intake.
Serum FGF21 level was significantly correlated with left ventricular systolic function at baseline and higher levels resulted in greater levels of cardiac death.
In conclusion, our study, which focused on hepatic FGF21 and omentin (zeige ITLN1 Antikörper)-1 mRNA expression, confirmed marked expression of both molecules in the liver of morbidly obese patients with NAFLD (zeige TSC2 Antikörper).
Serum FGF21 concentrations are decreased in anorexia nervosa and elevated in obesity. They are independently and positively related to BMI and insulin (zeige INS Antikörper) resistance
FGF-21 was positively associated with 10-year CHD (zeige CHDH Antikörper) risk
The present study shows that expression of the FGF21 gene is strongly up-regulated during the transition period; the up-regulation of FGF21 might play an important role in the adaptation of liver metabolism during early lactation in dairy cows such as in other species.
RESULTS: The results showed that serum FGF-21 levels were significantly higher in both groups treated with a controlled-energy diet, while FGF-21 levels in both groups treated with moderate-energy diet were low.
liver-derived FGF21 regulates the use of lipid reserves during lactation via focal actions on liver and white adipose tissue.
FGF-21 has anti-inflammatory effects in Type 2 diabetes mellitus
These data suggest that Fgf21 acts as one of intrathymic cytokines in the neonatal and juvenile thymus, involving thymocyte development in a beta (zeige SUCLA2 Antikörper)-Klotho (zeige KLB Antikörper)-independent manner.
During pregnancy, both systemic and cardiac-produced Fgf21 act on the heart, leading to the normal physiological cardiac changes that are associated with pregnancy.
our results demonstrated that FGF21 promotes cell cycle exit and enhances myogenic differentiation of C2C12 cells. This study provided new evidence that FGF21 promotes myogenic differentiation, which could be useful for better understanding the roles of FGF21 in myogenesis.
We will clarify the positive and negative signaling mechanisms which control the stress-related expression of FGF21 through the ISR pathway. Moreover, we will examine the role of FGF21 as an interorgan coordinator of survival functions in metabolic and stress disorders. We conclude that FGF21 can be viewed as a cell non-autonomous enhancer of longevity in mammals.
under nutrient-limiting conditions that stimulate ATF4 (zeige ATF4 Antikörper) activity, TRIB3 (zeige TRIB3 Antikörper) is implicated in the regulation of metabolic adaptation by restraining the transcription of Fgf21.
alcohol-induced FGF21 expression is a hepatic adaptive response to lipid dysregulation.
the adipose-derived FGF21-CCL11 axis triggers cold-induced beiging and thermogenesis by coupling sympathetic nervous system to activation of type 2 immunity in subcutaneous white adipose tissue.
These results uncover a negative feedback loop in which CREBH (zeige CREB3L3 Antikörper) regulates nonesterified fatty acid flux from adipose tissue to the liver via FGF21.
Chronic high-sucrose diet does not lead to obesity in mice. Data suggest that high-sucrose diet leads to up-regulation of Fgf21 expression in liver and brown adipose tissue plus high levels of Fgf21 in plasma which eventually lead to increased energy expenditure and, thus, does not cause obesity in this species.
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factor has not yet been determined.
fibroblast growth factor 21