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Fgf3 (zeige FGF3 Antikörper) and Fgf10a work in concert to promote maturation of the epibranchial placodes in zebrafish.
Fgf10 and Fgf3 (zeige FGF3 Antikörper) secreted from the forming neurohypophysis exert direct guidance effects on hypothalamic neurosecretory axons.
through the analysis of fgf10(-/-); fgf24(-/-) embryos, the specific role of these two FGF ligands in the induction of the ventral pancreas and in the repression of the hepatic fate was revealed.
fgf10a, which is expressed in the mesenchyme surrounding non-hepatic endodermal cells, negatively impacts the regulative capacity of endodermal tissues.
Functional investigation of a subset of these genes, fgf10a, tgfb2 (zeige TGFB2 Antikörper), pax9 (zeige PAX9 Antikörper), and smad5 (zeige SMAD5 Antikörper) revealed their necessity in zebrafish palatogenesis.
Data show that the Ihha-Fgf10 regulatory interaction is realized through a signaling feedback loop between the Ihha-expressing epithelium and Fgf10-expressing mesenchyme.
These data provide in vivo evidence that endodermal cells outside the liver-forming region retain hepatic competence and show that an extrinsic signal, Fgf10a, negatively regulates hepatic competence.
Positional cloning identifies fgf10 as the gene disrupted in daedalus.
Fgf10 signaling from the adjacent mesenchyme is responsible for refining the boundaries
Fgf10 acts redundantly with Fgf24 in the pancreatic lateral plate mesoderm and they are both required to specify the ventral pancreas.
We report the ophthalmological and genetic study of a 19-year-old woman and her relatives suffering from this syndrome. A new probably pathogenic variant is described in the FGF10 gene.
We have revealed significant association of FGFR2 (zeige FGFR2 Antikörper) and MAP3K1 (zeige MAP3K1 Antikörper) polymorphisms with breast cancer.
These results indicated that FGF-2 (zeige FGF2 Antikörper), but not FGF-10, may be supplemented during stem cell expansion to prime cells for successful chondrogenesis and osteogenesis.
The present data indicate that non-natural FGFR2 (zeige FGFR2 Antikörper) ligands, such as FGF10 and FGF19 (zeige FGF19 Antikörper), are important factors in the pathophysiology of Aspert syndrome.
data suggest that the strongest signal of association at 5p12 is mediated through coordinated activation of FGF10 and MRPS30 (zeige MRPS30 Antikörper), two candidate genes for breast cancer pathogenesis
Fgf10 signaling has an essential role in the formation of lipofibroblasts during late lung development
Expression of Fibroblast Growth Factor 10 is correlated with poor prognosis in gastric adenocarcinoma.
FGF10 has a role in protecting neuron against oxygen-glucose deprivation injury through inducing heme oxygenase-1 (zeige HMOX1 Antikörper)
Data identify autocrine activation of FGF signaling as an essential mechanism in promoting Pten-deficient skin tumors.
precursor of the hormone Irisin (zeige FNDC5 Antikörper) (FNCD5) were abundantly expressed in all three fat depots, along with fibroblast growth factors (FGF) FGF1 (zeige FGF1 Antikörper), FGF7 (zeige FGF7 Antikörper) and FGF10, whereas, FGF19 (zeige FGF19 Antikörper) and FGF21 (zeige FGF21 Antikörper) were undetectable.
It is concluded that during early pseudoglandular stage of lung development Ptch1 (zeige PTCH1 Antikörper) patterns Fgf10 and regulates Foxf1 (zeige FOXF1 Antikörper) expression in the lung mesenchyme to direct branch formation and this is essential for proper lobe formation and lung function.
small interfering RNA knockdown of FGFR2 (zeige FGFR2 Antikörper) suppressed PI3K/Akt (zeige AKT1 Antikörper) pathway activation by FGF10 and abolished its anti-apoptotic and neurite repair effects in vitro.
the response of FGF10(+) progenitors and differentiated Airway smooth muscle cells to growth factor treatment in real time using lineage tracing in the background of an air-liquid interface (ALI) culture system.
FGF10 pathway is downregulated in Dlx5 (zeige DLX5 Antikörper)(-/-) mice, and activation of FGF10 signaling rescues cranial neural crest cell proliferation and myogenic differentiation.
Inactivation of ALX4/Alx4 (zeige ALX4 Antikörper) causes lacrimal gland aplasia in both human and mouse. These results reveal a key role of Alx4 (zeige ALX4 Antikörper) in mediating FGF-Shp2 (zeige PTPN11 Antikörper)-FGF signaling in the neural crest for lacrimal gland development.
show that during homeostasis, basal stem/progenitor cells in cartilaginous airways maintain their stem cell state by downregulating the Hippo pathway (resulting in increased nuclear Yap (zeige YAP1 Antikörper)), which generates a localized Fgf10-expressing stromal niche
reactivating SHH (zeige SHH Antikörper) signaling in mutant lungs rescued the tip dilation phenotype and attenuated FGF signaling. Importantly, the reduced SHH (zeige SHH Antikörper) signaling activity did not appear to be caused by decreased Shh (zeige SHH Antikörper) expression or protein stability; instead, biologically active form of SHH (zeige SHH Antikörper) proteins were reduced in both the Ext1 (zeige EXT1 Antikörper) mutant epithelium and surrounding wild type mesenchymal cells.
that miR (zeige MLXIP Antikörper)-205 in the surface ectoderm functions to ensure robust activation of pathways associated with Fgf10 signaling.
Mesenchymal FGF10 controls the size of the taste bud papillary area, while overall patterning remains unchanged. Results show that FGF signaling negatively affects the extent of canonical Wnt (zeige WNT2 Antikörper) signaling, which is the main activation pathway during fungiform papillae development; however, this effect does not occur at the level of gene transcription.
Sox9 (zeige SOX9 Antikörper) is positively regulated by mesenchymal Fgf10, a process that requires active Erk (zeige EPHB2 Antikörper) signaling during salivary gland development
We found no difference between treatments regarding embryo production, developmental speed, and gene expression. CONCLUSION: In conclusion, the presence of FGF10 during IVM had no effect on embryo production, developmental speed, and gene expression.
The present data suggest a role for FGF10 in the control of fetal folliculogenesis in cattle.
BMP15 (zeige BMP15 Antikörper) and FGF10 stimulate expansion of in cumulus-oocyte complexes by driving glucose metabolism toward hyaluronic acid production and controlling gene expression in the ovulatory cascade.
FGF10 and its receptor FGFR2b are more expressed in subordinate follicles; FGF10 acts as an important regulator of follicular growth in cattle.
These data support a role for FGF10 and fibroblast growth factor receptor 2B in signaling to granulosa cells from theca cells and/or the oocyte.(fibroblast growth factor receptor 2B)
FGF10 mRNA expression did not change during functional luteolysis, whereas FGFR2B mRNA abundance decreased significantly at 2, 4, and 12 hr after PGF2alpha, and returned to pretreatment levels for the period 24-64 hr post-PGF2alpha
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing.
, fibroblast growth factor 10
, keratinocyte growth factor 2
, produced by fibroblasts of urinary bladder lamina propria
, obg-like ATPase 1