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Mouse (Murine) ERBB3 Protein expressed in Human Cells - ABIN2008508
Alimandi, Romano, Curia, Muraro, Fedi, Aaronson, Di Fiore, Kraus: Cooperative signaling of ErbB3 and ErbB2 in neoplastic transformation and human mammary carcinomas. in Oncogene 1995
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Human ERBB3 Protein expressed in Human Cells - ABIN3216381
Wallasch, Weiss, Niederfellner, Jallal, Issing, Ullrich: Heregulin-dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3. in The EMBO journal 1995
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identified P2RX2 (zeige P2RX2 Proteine), KCNQ5 (zeige KCNQ5 Proteine), ERBB3 and SOCS3 (zeige SOCS3 Proteine) to be associated with the progression of age-related hearing impairment
In this study, authors analyzed the immunoexpression of EGFR (zeige EGFR Proteine), HER2 (zeige ERBB2 Proteine) (EGFR2) and HER3 (EGFR3) in 41 cases of serous borderline ovarian tumors and carcinomas, in relation to the degree of differentiation and tumor stage.
Results demonstrate that 4-PBA promotes gastric cancer cells migration through upregulation of HER3/HER4 (zeige ERBB4 Proteine) subsequent to increased levels of acetyl-histone and activation of ERK (zeige EPHB2 Proteine) signaling.
miR152 was found to be involved in the proliferation and metastasis of ovarian cancer cells through repression of ERBB3 expression.
NRG1 (zeige NRG1 Proteine)-dependent activation of HER3 induces primary resistance to trastuzumab in HER2 (zeige ERBB2 Proteine)-overexpressing breast cancer cells. HER3 monoclonal antibody combined with trastuzumab may serve as a treatment choice for patients with primary resistance to trastuzumab.
This phase Ib study was designed to determine the MTD (zeige MT1E Proteine), safety, preliminary efficacy, and pharmacokinetics of the HER3 (ErbB3) mAb SAR256212 in combination with the oral PI3K (zeige PIK3CA Proteine) inhibitor SAR245408 for patients with metastatic or locally advanced solid tumors.
the present study suggests that HER2 (zeige ERBB2 Proteine) has an important role in the regulation of the cancer stem-like cells phenotype in ALK translocated lung cancers that is mainly orchestrated by HER2 (zeige ERBB2 Proteine)/HER3 heterodimers.
HER3 phosphorylation by EGFR (zeige EGFR Proteine) depends on the ability of EGFR (zeige EGFR Proteine) to homo-oligomerize.
To determine additional resistance mechanisms to cetuximab treatment besides HER3 signaling.
Study shows ErbB3 expression was markedly decreased in suicide completers compared to controls.
Widespread expression of ErbB3 receptor mRNAs was found throughout the telencephalon of juvenile and adult monkeys with in situ hybridization.
data confirmed that an ErbB3-driven pathway mediates a net positive influence in an in vivo model closely resembling human repair
Result suggest the potential for a paracrine signalling network whereby basal cells secrete neuregulin 1 (Nrg1 (zeige NRG1 Proteine)), which acts on luminal cells via Erbb3 and Erbb4 (zeige ERBB4 Proteine) receptors.
The authors demonstrate that ErbB3 signaling is required for the embryonic development of the enteric nervous system.
These studies demonstrate that ErbB3, like ErbB4 (zeige ERBB4 Proteine), enhances lactogenic expansion and differentiation of the mammary gland during pregnancy, through activation of Akt (zeige AKT1 Proteine) and STAT5A (zeige STAT5A Proteine), two targets crucial for lactation.
The data suggest that ErbB3 restricts Paneth cells numbers through PI3K-mediated suppression of Atoh1 (zeige ATOH1 Proteine) levels leading to inhibition of Paneth cells differentiation, with important implications for regulation of the intestinal stem cells niche.
Our results support a role for the hepatocellular ERBB (zeige EGFR Proteine) tyrosine kinases in fibrogenesis. Maximal impact to fibrogenesis occurred in the ERBB3 and EGFR (zeige EGFR Proteine)-ERBB3 DKO models, suggesting that EGFR (zeige EGFR Proteine)-ERBB3 heterodimeric signaling in damaged hepatocytes may play a more important role in liver fibrosis than EGFR-EGFR (zeige EGFR Proteine) homodimeric signaling.
nuc-ErbB3 directly regulates levels of H3K27me3 in Schwann cells
Data indicate that Sonic hedgehog (Shh (zeige SHH Proteine)) stimulate branching morphogenesis (BrM (zeige SMARCA2 Proteine)) and induced synthesis of mRNAs for Ptch1 (zeige PTCH1 Proteine) protein, epidermal growth factor (EGF (zeige EGF Proteine)) and receptors of the ErbB (zeige EGFR Proteine) receptors ErbB1 (zeige EGFR Proteine), ErbB2 (zeige ERBB2 Proteine) and ErbB3.
ERBB3 is required for wound healing and for the progression of skin tumors in mice.
The expression of ERBB3 in combination with ERBB4 (zeige ERBB4 Proteine) significantly amplifies proliferation of lymphocytes upon ligand stimulation.
Data indicate that increased expression of erbB3 plays a pivotal role in activating downstream PI-3K/Akt (zeige AKT1 Proteine) pathway and promoting erbB2 (zeige ERBB2 Proteine)-driven mammary/breast tumorigenesis.
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.
proto-oncogene-like protein c-ErbB-3
, receptor tyrosine-protein kinase erbB-3
, tyrosine kinase-type cell surface receptor HER3
, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
, receptor tyrosine kinase ErbB3
, receptor tyrosine-protein kinase erbB-3-like
, avian erythroblastosis oncogene B 3 receptor
, glial growth factor receptor
, receptor tyrosine kinase
, avian erythroblastosis oncogene B 3
, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3
, v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3