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Collectively, these data suggest that ATRA attenuates bleomycin-induced pulmonary fibrosis by regulating EphA2 (zeige EPHA2 Proteine)-EphrinA1 and PI3K-Akt (zeige AKT1 Proteine) signaling.
Lipopolysaccharide exposure significantly up-regulated EphA2 (zeige EPHA2 Proteine) and EphrinA1 expression.
Activation of EphA1 (zeige EPHA1 Proteine)-Epha receptor axis attenuates diabetic nephropathy in mice.
Following ephrin-A1 stimulation, truncated EphA2 (zeige EPHA2 Proteine) did not detectably interfere with the phosphorylation of endogenous EphA2 (zeige EPHA2 Proteine), and it potentiated cell adhesion possibly through modulation of integrin avidity.
ADAM12 (zeige ADAM12 Proteine) enhanced ephrin-A1 cleavage in response to transforming growth factor-betra1 in primary tumors.
S100A8 (zeige S100A8 Proteine) and ephrin-A1 contribute to lung metastasis.
We used in utero electroporation-mediated EphA7 overexpression in developing somatosensory corticothalamic axons to dissect EphA7/ephrin-A-dependent mechanisms involved in regulating both initial targeting and postnatal growth of the CT projections.
Elevated levels of ephrin-A1 may contribute to diabetic keratopathies by persistently engaging EphA2 (zeige EPHA2 Proteine) and prohibiting Akt (zeige AKT1 Proteine)-dependent corneal epithelial repair processes.
Data indicate that ephrin-A1 regulates cardiac valve development, making ephrin-A1-deficient mice a novel model for congenital heart defects.
Cooperation between Slit2 and ephrin-A1 regulates a balance between the pro- and antiangiogenic functions of Slit2.
ephrin-A1 seems to be remarkably involved in elementary processes of endothelial migration like cellular polarization, migratory direction and speed.
Findings show that EFNA1 expression is a useful marker for predicting a high risk of recurrence in hepatocellular carcinoma patients but not EPHA2 (zeige EPHA2 Proteine).
Results suggest that EFNA1 is involved in colorectal tumorigenesis, and rs12904 A>G polymorphism in the 3' UTR of EFNA1 is associated with CRC (zeige CALR Proteine) susceptibility in a Chinese population.
EphA2 (zeige EPHA2 Proteine)-ephrinA1 trans-endocytosis is sensitive to the mechanical properties of a cell's microenvironment
Ephrin-A1 is upregulated in tumor microenvironment and promotes angiogenesis through a coordinated cross-talk with PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine)-dependent eNOS (zeige NOS3 Proteine) activation.
The interaction between ephrin-As, Eph (zeige EPHA1 Proteine) receptors and integrin alpha3 is plausibly important for the crosstalk between Eph (zeige EPHA1 Proteine) and integrin signalling pathways at the membrane protrusions and in the migration of brain cancer cells.
Increased expression of EFNA1 mRNA is associated with gastric cancer.
Expression of EPHRIN-A1 tends to be associated with worse survival in head and neck cancer.
EFNA1 expression is a useful marker for predicting high risk of relapse and cancer-related death in patients who have undergone curative resection for CRC (zeige CALR Proteine).
Findings suggest that the glycosylation on ephrin-A1 plays a critical role in the binding and activation of the EphA2 (zeige EPHA2 Proteine) receptor.
expression of Eph (zeige EPHA1 Proteine) A1, A2, A4, and A7 was strongly detected in endometrial epithelial cells during early pregnancy.
The Eph-Ephrin A system might play an important role in regulating the swine contact between blastocysts and endometrium during embryo implantation.
Eph (zeige EPHA1 Proteine) A-ephrin A1 system is a positive factor in the increase and maintenance of epithelial cells in mammary glands of cows; the signaling system contributes to development, remodeling, and functionality of normal mammary glands and could overcome mastitis.
This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin which binds to the EPHA2, EPHA4, EPHA5, EPHA6, and EPHA7 receptors. Two transcript variants that encode different isoforms were identified through sequence analysis.
EPH-related receptor tyrosine kinase ligand 1
, eph ligand family-a
, ephrin A1
, immediate early response protein B61
, TNF alpha-induced protein 4
, eph-related receptor tyrosine kinase ligand 1
, ligand of eph-related kinase 1
, tumor necrosis factor alpha-induced protein 4
, tumor necrosis factor, alpha-induced protein 4
, ephrin-A1 b