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Combining CSF1R inhibitor with a CXCR2 (zeige CXCR2 Proteine) antagonist blocked granulocyte infiltration of tumors and showed strong anti-tumor effects.
These findings reveal a novel and functionally important role for EHD1 (zeige EHD1 Proteine) in governing CSF-1R signalling via regulation of anterograde transport of CSF-1R to the macrophage cell surface.
Our findings thus demonstrate that microenvironmental alteration by CSF-1R blockade renders tumor cells more susceptible to receptor tyrosine kinase (zeige ERBB3 Proteine) inhibition in a preclinical glioblastoma model, which may have important translational relevance
NMB or NMBR silencing inhibited M-CSF/c-Fms-mediated downstream signaling pathways like activation of ERK (zeige EPHB2 Proteine) and Akt (zeige AKT1 Proteine) and induction of D-type cyclins, cyclin D1 (zeige CCND1 Proteine) and D2.
CSF-1R role in the development of erythro-myeloid progenitor cells in the developing fetal liver
analysis of CSF1R-deficient mice establishes a distinct role of CSF1R in fetal B-lymphopoiesis.
study, therefore, provided insights into the sequence-structure-function relationships of the M-CSF/c-FMS interaction and of ligand/receptor tyrosine kinase (zeige ERBB3 Proteine) interactions in general.
this study shows that the iRhom2 (zeige RHBDF2 Proteine)/ADAM17 (zeige ADAM17 Proteine) pathway plays an important role in regulating CSF1R expression in the myeloid cell compartment at steady state, and in modulating development of monocytes/macrophages during their repopulation
this study shows that macrophage maturation is accompanied by colony-stimulating factor (zeige CSF2 Proteine) 1hypomethylation, and illustrates for the first time the ability of protein kinase A to increase Csf1r DNA methylation (zeige HELLS Proteine)
Targeting of macrophages by either CSF1R signaling blockade or clodronate liposome-mediated cell killing has marked inhibitory effects on established leukemia.
Hypoxia promotes glioma-associated macrophage infiltration via periostin (zeige POSTN Proteine) and subsequent M2 polarization by upregulating TGF-beta (zeige TGFB1 Proteine) and M-CSFR.
CSF-1R is a novel therapeutic target.
The phenotype of adult-onset leukoencephalopathy axonal spheroids and pigmented glia caused by CSF1R mutations is affected by sex
Results suggest that TP63 (zeige TP63 Proteine) rs7631358 G > A and CSF1R rs10079250 A > G may affect the risk and prognosis of lung cancer in never-smoking females.
study, therefore, provided insights into the sequence-structure-function relationships of the M-CSF (zeige CSF1 Proteine)/c-FMS interaction and of ligand/receptor tyrosine kinase (zeige RET Proteine) interactions in general.
findings suggest that expression of wild-type CSF1R in some cells, whether achieved by mosaicism or chimerism, may confer benefit in hereditary diffuse leukoencephalopathy with axonal spheroids.
This review showed that CSF1R mutation is related to Hereditary diffuse leukoencephalopathy with axonal spheroids.
High CSF-1R expression is associated with Clear Cell Renal Cell Carcinoma (zeige MOK Proteine).
The aim of this study was to compare the expression of CSF-1R in nasopharyngeal carcinoma to nasopharyngitis.
CSF1R mutations account for 10% of idiopathic adult onset leukodystrophies.
Data suggest that fms is not required for establishing a population of precursor cells during embryogenesis but is required for recruiting pigment cell precursors to xanthophore fates, with concomitant effects on melanophore organization.
The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction.
, macrophage colony-stimulating factor 1 receptor
, proto-oncogene c-Fms
, proto-oncogene fms
, CD115 antigen
, FMS proto-oncogene
, McDonough feline sarcoma viral (v-fms) oncogene homolog
, macrophage colony stimulating factor I receptor
, colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog
, platelet-derived growth factor receptor, beta polypeptide
, protein-tyrosine kinase
, macrophage colony-stimulating factor receptor
, csf1r protein
, colony stimulating factor 1 receptor
, macrophage colony-stimulating factor 1 receptor-like
, fms proto-oncogene
, fms proto-oncogene homolog
, proto-oncogene c-Fms homolog
, proto-oncogene fms homolog