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anti-Mouse (Murine) ARPC2 Antikörper:
anti-Rat (Rattus) ARPC2 Antikörper:
anti-Human ARPC2 Antikörper:
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Human Polyclonal ARPC2 Primary Antibody für IHC (p), IHC - ABIN249530
Isogai, van der Kammen, Leyton-Puig, Kedziora, Jalink, Innocenti: Initiation of lamellipodia and ruffles involves cooperation between mDia1 and the Arp2/3 complex. in Journal of cell science 2015
Show all 4 Pubmed References
Human Polyclonal ARPC2 Primary Antibody für IHC, ELISA - ABIN184748
Welch, DePace, Verma, Iwamatsu, Mitchison: The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. in The Journal of cell biology 1997
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Cow (Bovine) Polyclonal ARPC2 Primary Antibody für WB - ABIN2787750
Cai, Marshall, Uetrecht, Schafer, Bear: Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge. in Cell 2007
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WASH is a bimodular protein and a component of the BLOC-1 complex in which the C terminus is involved in Arp2/3-mediated actin nucleation, whereas the N-terminal portion is required for its regulation and localization in the cells
In the association analysis of 110 gastric cancer tissues, ARPC2 showed significant associations with large tumor size, lymph node invasion, and high tumor stage. In addition, ARPC2-positive patients exhibited lower RFS and OS rates compared with ARPC2-negative patients. We thus identify that ARPC2 plays an aneretic role in human gastric cancer and provided a new target for gastric cancer therapy.
Downregulation of the ARP2 (zeige ACTR2 Antikörper)/3 complex signaling pathway, a common final pathway for multiple signaling cascades that regulate the actin cytoskeleton, would compromise the structural stability of spines, leading to their loss. In concert with findings from deletion of the ARP2 (zeige ACTR2 Antikörper)/3 complex in mice, these findings support the idea that spine deficits in the DLPFC may contribute to subcortical hyperdopaminergia in schizophrenia.
Recent reports now demonstrate a novel aspect of the ARP2 (zeige ACTR2 Antikörper)/3 complex and the nucleating-promoting factors in the maintenance of endothelial barrier function and junction remodeling of established endothelial cell junctions.
FOXF1 (zeige FOXF1 Antikörper) repressed cell growth and expression of collagen-1 and actin-related protein 2 (zeige ACTR2 Antikörper)/3 complex, subunit 2 (zeige CCT2 Antikörper).
The Arp2 (zeige ACTR2 Antikörper)/3 complex is recruited to invading Rickettsia parkeri and is required for efficient invasion.
Filopodia initiation: focus on the Arp2 (zeige ACTR2 Antikörper)/3 complex and formins
Endogenous Nogo-B (zeige RTN4 Antikörper), which may exert its effects through ARPC 2/3 and MYL-9 (zeige MYL9 Antikörper), is necessary for the migration and contraction of airway smooth muscle cells.
The results identify Arp2/3 complex as a key factor in the generation of the dynamic actin cluster during mitosis.
Arp2/3 complex genes have roles in actin organization and possibly in cancer phenotypes
Gmfg (zeige GMFG Antikörper) has two separate binding sites on Arp2 (zeige ACTR2 Antikörper)/3 complex with high (site 1) and low (site 2) affinity. X-ray crystallography revealed closely located positions of Gmfg (zeige GMFG Antikörper) in site 1. Molecular dynamics simulation allowed determining the binding pocket for Gmfg (zeige GMFG Antikörper) in site 2.
The GMF-Arp2 interface reveals how the ADF-H actin-binding domain in GMF is exploited to specifically recognize Arp2/3 complex and not actin.
This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined.
actin related protein 2/3 complex, subunit 2, 34kDa
, actin related protein 2/3 complex subunit 2
, actin-related protein 2/3 complex subunit 2
, arp2/3 complex 34 kDa subunit
, ARP2/3 protein complex subunit 34
, actin related protein 2/3 complex, subunit 2 (34 kD)