anti-Pyruvate Kinase, Liver and RBC (PKLR) Antikörper

Bezeichnung:: anti-Pyruvate Kinase, Liver and RBC Antikörper (PKLR)

Auf www.antikoerper-online.de finden Sie aktuell 148 Pyruvate Kinase, Liver and RBC (PKLR) Antikörper von 19 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Pyruvate Kinase, Liver and RBC Kits (40) und Pyruvate Kinase, Liver and RBC Proteine (19) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 219 Pyruvate Kinase, Liver and RBC Produkte verfügbar.

Synonyme:: Pk-1, Pk1, PKL, Pklg, PKLR, PKR, PKRL, R-PK, RPK, wu:fd15e01, wu:fi37e08

Alle Antikörper anzeigen	Gen	GeneID	UniProt
	PKLR	5313	P30613
	PKLR	24651	P12928
	PKLR	18770
Alle Spezies anzeigen Weitere Synonyme anzeigen

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Verknüpfte Pathways mit anti-Pyruvate Kinase, Liver and RBC Antikörper

Ribonucleoside Biosynthetic Process

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Am meisten referenzierte anti-Pyruvate Kinase, Liver and RBC Antikörper

Rabbit Polyclonal PKLR Primary Antibody für IHC (p), IHC - ABIN269613 : Jindal, Merchant, Balschi, Zhangand, Koren: Proteomic analyses of transgenic LQT1 and LQT2 rabbit hearts elucidate an increase in expression and activity of energy producing enzymes. in Journal of proteomics 2012 (PubMed)
Human Polyclonal PKLR Primary Antibody für IHC, IHC (p) - ABIN4345879 : Kowalski, Nocon, Gamian, Kołodziej, Rakus: Association of C-terminal region of phosphoglycerate mutase with glycolytic complex regulates energy production in cancer cells. in Journal of cellular physiology 2012 (PubMed)

Weitere Antikörper gegen Pyruvate Kinase, Liver and RBC Interaktionspartner

Human Pyruvate Kinase, Liver and RBC (PKLR) Interaktionspartner

Results show that different residues contribute to the two allosteric functions: regulation by the activator fructose-1,6-bisphosphate (Fru (zeige ZBTB22 Antikörper)-1,6-BP) and alanine, the inhibitor. Only a small fraction of mutated residues perturbed inhibition by alanine. In contrast, a large percentage of mutated residues influenced activation by Fru (zeige ZBTB22 Antikörper)-1,6-BP; inhibition by alanine is not simply the reverse of activation by Fru (zeige ZBTB22 Antikörper)-1,6-BP.
PKLR gene sequencing in 15 Spanish patients affected by pyruvate kinase deficiency (PKD (zeige PRKD1 Antikörper)) was performed. Six out of the 18 alleles found were new mutations which had not been described previously, with the PKLR c.721G>T mutation being the most prevalent (26.67%), followed by the PKLR c.1456C>T mutation (13.33%).
Gene copy number variation (CNV) of the PKLR, FCGR2A (zeige FCGR2A Antikörper), FCGR2C, and FCGR3 (zeige CD16 Antikörper) genes is associated with malaria severity, and our results provide evidence for a role of CNV in host responses to malaria.
Genotype-phenotype correlations for the novel missense mutations found in the PKLR gene in PK deficiency among Tunisian cases were investigated by three-dimensional structure analysis.
Data show that pyruvate kinase (PK) activity was decreased in the GATA1 (zeige GATA1 Antikörper) hemizygous state and PKLR c.1284delA variant.
An update of PKLR gene mutation database has been presented. (Review)
Two Novel Missense Mutations and a 5bp Deletion in the Erythroid-Specific Promoter of the PKLR Gene in Two Unrelated Patients With Pyruvate Kinase Deficient Transfusion-Dependent Chronic Nonspherocytic Hemolytic Anemia.
PKLR promotes colorectal cancer liver colonization through induction of glutathione synthesis.
Pyruvate kinase variants modulate malaria phenotypes in a Thai population.
661G>A and 1528C>T mutations of PKLR gene are associated with pyruvate kinase deficiency.

Pig (Porcine) Pyruvate Kinase, Liver and RBC (PKLR) Interaktionspartner

The existence of mitochondrial Pyruvate kinase was confirmed by immunological analysis in pig liver mitochondria.

Mouse (Murine) Pyruvate Kinase, Liver and RBC (PKLR) Interaktionspartner

AMPD3 deficiency increases the level of ATP in erythrocytes, but does not improve anemia due to pyruvate kinase deficiency and leads to erythrocyte dysfunction.
Pyruvate kinase deficiency in mice protects against malaria

Pyruvate Kinase, Liver and RBC (PKLR) Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA). Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Pyruvate Kinase, Liver and RBC (PKLR)

pyruvate kinase L/R (PKLR) Antikörper
pyruvate kinase, liver and RBC (Pklr) Antikörper
pyruvate kinase L/R (pklr) Antikörper
pyruvate kinase, liver and RBC L homeolog (pklr.L) Antikörper
pyruvate kinase, liver and RBC (pklr) Antikörper
pyruvate kinase, liver and RBC (PKLR) Antikörper
pyruvate kinase liver and red blood cell (Pklr) Antikörper
pyruvate kinase L/R (Pklr) Antikörper

Pk-1 Antikörper
Pk1 Antikörper
PKL Antikörper
Pklg Antikörper
PKLR Antikörper
PKR Antikörper
PKRL Antikörper
R-PK Antikörper
RPK Antikörper
wu:fd15e01 Antikörper
wu:fi37e08 Antikörper

Bezeichner auf Proteinebene für PKLR

R-type/L-type pyruvate kinase , pyruvate kinase 1 , pyruvate kinase PKLR , pyruvate kinase isozyme R/L , pyruvate kinase isozymes L/R , pyruvate kinase isozymes R/L , pyruvate kinase type L , pyruvate kinase, liver and blood cell , red cell/liver pyruvate kinase , L-PK , pyruvate kinase, liver and red blood cell , pyruvate kinase, liver and RBC , Pyruvate kinase isozyme R , Pyruvate kinase isozymes R/L , pyruvate kinase isozymes R/L-like

GENE ID	SPEZIES
5313	Homo sapiens
24651	Rattus norvegicus
114551	Danio rerio
398967	Xenopus laevis
469513	Pan troglodytes
490425	Canis lupus familiaris
539579	Bos taurus
719152	Macaca mulatta
100355056	Oryctolagus cuniculus
100380137	Xenopus (Silurana) tropicalis
100391903	Callithrix jacchus
100533203	Sus scrofa
18770	Mus musculus
100716756	Cavia porcellus

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