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Three genes-ATP6V1G1 in 9q32, GMPS in 3q25.31, and TBX5 in 12q24.21-exhibited concomitant hypermethylation and decreased expression. The i(12p)-positive cells displayed global hypomethylation of gene-poor regions on 12p, a footprint previously associated with constitutional and acquired gains of whole chromosomes as well as with X-chromosome inactivation in females
Cytoplasmic sequestration of GMPS requires ubiquitylation by TRIM21.
analysis of USP7/HAUSP activation by its C-terminal ubiquitin-like domain and allosteric regulation by GMP-synthetase
In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP.
guanine monphosphate synthetase
, GMP synthase
, glutamine-hydrolyzing GMP synthase
, GMP synthase [glutamine-hydrolyzing]
, GMP synthetase
, glutamine amidotransferase
, guanine monophosphate synthetase
, GMP synthase [glutamine-hydrolyzing]-like
, MLL/GMPS fusion protein
, guanosine 5'-monophosphate synthase